A comparison of the clinical duration and recovery characteristics of cisatracurium after priming using rocuronium or cisatracurium: preliminary study

Abstract

BackgroundThe priming technique can speed up the onset of cisatracurium during intubation. However, there have been no reports on the effect of the priming technique on duration or recovery profile of cisatracurium. Therefore, we attempted to determine whether or not a priming technique with rocuronium or cisatracurium can affect clinical duration or recovery profiles of cisatracurium.MethodsA total of 36 patients, ASA I and II, who were scheduled to undergo elective surgery, were enrolled. The patients were randomized into three groups and administered different drugs for the priming technique. Patients in group 1 received normal saline (control group). Patients in group 2 received rocuronium (0.06 mg/kg), and those in group 3 received cisatracurium (0.01 mg/kg) as a priming agent. Three minutes after injection of drugs, intubation doses of cisatracurium were administered (Group 1, 0.15 mg/kg; Groups 2 and 3, 0.14 mg/kg). Anesthesia was induced and maintained with propofol and remifentanil. Onset time, clinical duration, recovery index, recovery time, and total recovery time were measured by train of four monitoring.ResultsOnset time in the group 2 was significantly shorter than that of group 1 or 3 (P < 0.05). However, no significant differences in clinical duration, recovery index, recovery time, and total recovery time were observed among the three groups.ConclusionsPriming with rocuronium for 3 minutes resulted in significantly accelerated onset of cisatracurium. However, it did not affect the clinical duration and recovery profiles of cisatracurium.

Factors associated with anaesthetic complications in bariatric surgery at the Delafontaine Saint-Dénis Hospital

“…Cisatracurium was widely used in Badaoui's study (6), in contrast to this study. Several studies have shown that there is no difference in muscle relaxation between rocuronium and cisatracurium (35) This study has the weakness of being monocentric, but confirms the high frequency of complications in bariatric surgery.…”

Efficacy and Safety of Neuromuscular Blockade in Overweight Patients Undergoing Nasopharyngeal Surgery

“…As early as the 1990s, there was evidence that rocuronium can produce a more rapid onset of muscle relaxation than cisatracurium with equipotent intubating doses [ 22 ]. Other studies also showed that rocuronium provides shorter onset time [ 23 – 26 ], and priming with rocuronium significantly accelerated onset of cisatracurium [ 27 ]. Previous studies have also compared cisatracurium with rocuronium in tracheal intubation condition.…”

Adversities related to neuromuscular blockade and reversal

“…21,22 Uso simultâneo de BNMs adespolarizantes O uso simultâneo de BNMs adespolarizantes da mesma classe tende a promover interação aditiva, enquanto BNMs de diferentes classes interagem de forma sinérgica por afinidades distintas aos receptores pré e pós-sinápticos de acetilcolina. 21,[23][24][25] A duração do efeito clínico resultante do uso de BNMs diferentes depende da sequência de administração, pois a maioria dos receptores de acetilcolina permanece ligada à primeira droga injetada, predominando suas características no bloqueio. 24 Doses priming utilizadas para acelerar o início de ação dos BNMs são tão baixas que a interação sinérgica ou aditiva entre as drogas parece tornar-se pouco significativa.…”

“…24 Doses priming utilizadas para acelerar o início de ação dos BNMs são tão baixas que a interação sinérgica ou aditiva entre as drogas parece tornar-se pouco significativa. 25…”