A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery

Bennett, Melody; Shah, M.V.; Bembridge, J. L.

doi:10.1111/j.1365-2044.1994.tb03376.x

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…Data present means (95% CI). similar results (Bennett et al, 1994;Yuan et al, 1998). Therefore, our experimental design achieved sufficient assay sensitivity to investigate drug-drug interactions with aspirin.…”

Section: Discussionsupporting

confidence: 66%

Morphine Interaction with Aspirin: a Double-Blind, Crossover Trial in Healthy Volunteers

Bartko

Schoergenhofer

Schwameis

et al. 2018

J Pharmacol Exp Ther

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Aspirin is a cornerstone in the antiplatelet therapy for acute coronary syndromes. Coadministration of morphine may potentially influence the intestinal absorption, pharmacokinetics, and pharmacodynamics, as seen with P2Y inhibitors. In this trial, healthy volunteers were randomized to receive morphine (5 mg, i.v. bolus injection) at one of seven different time points before, after, or with aspirin (162 mg, p.o.) in a double-blind, placebo-controlled fashion. After a 14-day washout, subjects received placebo instead of morphine. Pharmacokinetics were determined by liquid chromatography, and aspirin's effects were measured by platelet function tests (whole-blood platelet aggregation: multiplate, platelet plug formation: PFA-100). Morphine increased the total acetylsalicylic acid exposure by 20% compared with placebo when given simultaneously with aspirin, whereas and were not altered. Morphine had no significant effect on aspirin-induced platelet inhibition. In contrast to coadministration with P2Y inhibitors, morphine appears to have negligible interaction with aspirin.

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Section: Discussionsupporting

confidence: 66%

Morphine Interaction with Aspirin: a Double-Blind, Crossover Trial in Healthy Volunteers

Bartko

Schoergenhofer

Schwameis

et al. 2018

J Pharmacol Exp Ther

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“…Administration of opioid analgetic drugs could be a cause of delayed gastric emptying and drug absorption in the perioperative periods. [36][37][38] Opioids can increase tone and reduce motility in several gut segments, enhance absorption of fluids, and inhibit secretion. 39,40 Delayed gastric emptying could increase the risk of complications like vomiting and pulmonary aspiration.…”

Section: Discussionmentioning

confidence: 99%

Effects of Fentanyl and S(+)-ketamine on Cerebral Hemodynamics, Gastrointestinal Motility, and Need of Vasopressors in Patients With Intracranial Pathologies

Schmittner¹,

Vajkoczy²,

Horn

et al. 2007

Journal of Neurosurgical Anesthesiology

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In neurosurgical patients, opioids are administered to prevent secondary cerebral damage. Complications often related to the administration of opioids are a decrease in blood pressure affording the use of vasopressors and intestinal atonia. One alternative approach to opioids is the application of S(+)-ketamine. However, owing to a suspected elevation of intracranial pressure (ICP), the administration of S(+)-ketamine has questioned for a long time. The aim of the present study was to evaluate ICP, gastrointestinal motility, and catecholamine consumption in neurosurgical patients undergoing 2 different protocols of anesthesia using fentanyl or S(+)-ketamine. Twenty-four patients sustaining traumatic brain injury or aneurysmal subarachnoid hemorrhage received methohexitone plus either fentanyl or S(+)-ketamine to establish a comparable level of sedation. To reach an adequate cerebral perfusion pressure (CPP), the norepinephrine dosage was adapted successively. Enteral nutrition and gastrointestinal stimulation were started directly after admission on the critical care unit. ICP, CPP, and norepinephrine dosage were recorded over 5 days and also the time intervals to full enteral nutrition and first defecation. There was no difference regarding ICP, CPP, and the time period until full enteral nutrition or first defecation between both groups. Patients who underwent analgesia with S(+)-ketamine showed a trend to a lower demand of norepinephrine compared with the fentanyl group. Our results indicate that S(+)-ketamine does not increase ICP and that its use in neurosurgical patients should not be discouraged on the basis of ICP-related concerns.

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“…13 (2) In previous studies of GE assessed by paracetamol absorption, C max has failed to disclose a significant difference in GE rate, while t max has successfully shown it. 14,15 (3) Because C max is very highly correlated with AUC, some authors think that C max represents the extent rather than the rate of drug absorption. 13 The division of C max by AUC, which adjusts the potentially high correlation between the two quantities, eliminates the influence of the extent of absorption from C max .…”

Section: Discussionmentioning

confidence: 99%

Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations

Sanaka

Kawakami

Shimomura

et al. 2002

Journal of Gastroenterology

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A comparison of the effect on gastric emptying of alfentanil or morphine given during anaesthesia for minor surgery

Cited by 15 publications

References 7 publications

Morphine Interaction with Aspirin: a Double-Blind, Crossover Trial in Healthy Volunteers

Morphine Interaction with Aspirin: a Double-Blind, Crossover Trial in Healthy Volunteers

Effects of Fentanyl and S(+)-ketamine on Cerebral Hemodynamics, Gastrointestinal Motility, and Need of Vasopressors in Patients With Intracranial Pathologies

Gastric emptying of liquids is delayed by co-ingesting solids: a study using salivary paracetamol concentrations

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