A Comparison of the Erythrocyte Sedimentation Rate and Serum C-Reactive Protein Concentration in Elderly Patients

Kenny, Rose Anne; Saunders, A.; Coll, Anthony P.; Harrington, Michael G.; Caspi, Dan; Hodkinson, H. M.; Pepys, Mark B.

doi:10.1093/ageing/14.1.15

Cited by 11 publications

(4 citation statements)

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“…12 The majority of previous studies that have investigated the agreement between CRP and ESR values have included selected samples of patients with specific inflammatory diseases. 10,[13][14][15][16][17][18][19][20] More general studies comparing ESR and CRP have included patients with various diseases in the hospital [21][22][23][24][25][26] and primary care settings. [27][28][29] In general, CRP and ESR have similar diagnostic accuracy assessing acute inflammation, 10 though CRP tends to be more reliable for disease monitoring because CRP levels change faster than the ESR 12,26,27 and are less affected by patient age.…”

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

et al. 2021

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Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44.5% male; median age, 52 years; range, 18-91 years), randomly selected from a municipality in Spain. The participants underwent simultaneous measurements of ESR, serum CRP, and interleukin-6 concentrations. Alcohol consumption, smoking, and physical activity were evaluated by questionnaire. Body mass index (BMI) measurement and metabolic syndrome criteria were available for all participants.Results: Most (n = 1123, 74.9%) of the participants showed normal CRP and ESR values. Sixty-nine (4.6%) participants showed high CRP and ESR values. Seventy-two (4.8%) participants showed a discordant pattern of high ESR and normal CRP values, which was associated with age after adjusting for sex, alcohol consumption, physical activity, BMI, and the presence of metabolic syndrome (odds ratio [OR], 1.052; 95% CI, 1.034-1.071; P < .001). A total of 208 (13.8%) participants showed a discordant pattern of high CRP and normal ESR values, which was associated with BMI after adjusting for covariates (OR, 1.099; 95% CI, 1.064-1.136; P < .001). BMI appeared to be the main determinant of serum CRP concentrations in this population. Serum interleukin-6 concentrations were positively associated with the discordant pattern of high CRP and normal ESR values.Conclusion: In this general adult population with no overt inflammatory disease, the discordant pattern of high ESR and normal CRP was associated with greater age, whereas the pattern of high CRP and normal ESR was associated with higher BMI.

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Section: Introductionmentioning

confidence: 99%

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

et al. 2021

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“…Values were obtained with a 1:8 dilution of supernatants. For an explanation of groups I through IV, see useful for monitoring disease activity in certain patient groups (4,6). This is probably because CRP production is stimulated by IL-1 (9).…”

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confidence: 99%

Release of interleukin-1 by peripheral blood mononuclear cells in patients with tuberculosis and active inflammation

et al. 1986

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Peripheral blood monocytes from patients with active tuberculosis and acute inflammatory disease showed spontaneous interleukin-1 production when compared with those from control patients or healthy controls. Moreover, interleukin-l production appeared to be a more specific indicator of active disease than were other commonly used indices, such as the erythrocyte sedimentation rate and serum C-reactive protein levels.

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“…Therefore, CRP is considered superior to ESR on clinical, scientific and practical grounds [32,33] . Our findings on patients with lower respiratory tract infections corroborated this point of view, as we found higher and more discriminant responses of CRP than ESR.…”

Section: Discussionmentioning

confidence: 99%

“…We found that ESR was the second more useful parameter, only after CRP, for the differentiation between pneumonia and OALRTI, according to ROC curves, but its accuracy was lower than that CRP and in fact, it was excluded from the multivariate model owing to the higher weight of CRP. In addition to this better performance, the higher sensitivity and quicker and broader changes of CRP as compared with ESR [32,33,45] and the quickness of its determination [46,47] makes CRP the acute-phase reactant of choice for acute lower respiratory tract infections.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Acute-phase Reactants, Immunologic Markers and other Clinical and Laboratory Parameters in Patients with Pneumonia and Non-pneumonic Lower Respiratory Tract Infections

Collazos¹,

MartÃnez²,

Izquierdo³

2007

American J. of Infectious Diseases

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More efficacious tools to distinguish pneumonia from other acute lower respiratory tract infections (OALRTI) in facilities where radiologic studies are not easily or rapidly available are desirable to select the patients who should undergo chest radiographs, to avoid unnecessary visits to the emergency wards of hospitals and to optimize health resources. To this end we analyzed the relevance of many clinical and laboratory parameters, including acute-phase reactants and immune activation markers, in 98 patients with pneumonia and 149 with OALRTI seen at the emergency ward of our hospital. Many clinical and laboratory parameters were associated with the diagnosis of pneumonia in the univariate analysis. Among them, C-reactive protein proved to be the most discriminant for the differentiation between the two conditions (area under the ROC curve 0.83, 95%CI 0.78-0.89, P<0.0001). A multivariate logistic regression analysis revealed that C-reactive protein, presence of suggestive auscultatory findings, lower age, presence of pleuritic pain and lower percent of eosinophils were independently associated with the diagnosis of pneumonia. A formula was derived from this analysis, which, for the most discriminant cut-off level, correctly classified pneumonic and non-pneumonic patients with a sensitivity of 88% and specificity 90%. The area under the ROC curve of this predictive model was 0.93 (95% CI 0.89-0.96, P<0.0001). C-reactive protein, especially if combined with other easily obtained parameters, constitutes a useful adjunct for the differentiation of pneumonia from OALRTI. Routine measurement of these parameters could result in a more adequate utilization of resources.

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A Comparison of the Erythrocyte Sedimentation Rate and Serum C-Reactive Protein Concentration in Elderly Patients

Cited by 11 publications

References 0 publications

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions

Release of interleukin-1 by peripheral blood mononuclear cells in patients with tuberculosis and active inflammation

Evaluation of Acute-phase Reactants, Immunologic Markers and other Clinical and Laboratory Parameters in Patients with Pneumonia and Non-pneumonic Lower Respiratory Tract Infections

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