A comparison of the haemodynamic effects of propofol and isoflurane in pregnant ewes

Abstract

The purpose of this study was to compare the effects of inhaled isoflurane and a constant infusion of propofol on maternal haemodynamics and uterine arterial and umbilical venous flows in pregnant ewes. Late term pregnant ewes (n = 5) were randomly assigned to receive either inhaled isoflurane or an intravenous infusion of propofol for 1 h, each on separate occasions. Maternal systemic arterial, right atrial and pulmonary arterial blood pressures, cardiac index, systemic vascular resistance index, stroke volume index, heart rate, and uterine arterial and umbilical venous flows were determined over the 1 h period of each treatment. Data were analysed using an univariate analysis of variance for repeated measures performed on the ranks of the data. Propofol anaesthetized ewes had significantly higher heart rate (P = 0.0040), mean arterial pressure (P = 0.0003) and cardiac index (P = 0.0475) compared to isoflurane anaesthetized ewes. There were no significant differences in uterine arterial flows, umbilical venous flows, or other measured variables. Continuous propofol infusions maintain maternal haemodynamics at significantly higher levels than does inhaled isoflurane, while uterine arterial and umbilical venous flows do not differ significantly.

Effects of Propofol-Sevoflurane Anesthesia on the Maternal and Fetal Hemodynamics Blood Gases, and Uterine Activity in Pregnant Goats

“…Another report suggested that the maternal hemodynamics were less depressed with a continuous propofol infusion than with inhalation of isoflurane [11]. Consistent with these data, there was no finding indicating the hemodynamic suppression in this study.…”

“…Due to the rapid emergence and disappearance of the anesthetic effect depending on a rapid redistribution of the drug from the central nervous system [18,28], propofol can also be injected either continuously or repeatedly to maintain general anesthesia instead of the use of volatile anesthetics [21,30]. Some reports on propofol in pregnant animal, have shown that continuous propofol anesthesia would not adversely affect maternal or fetal heart rate and blood pressure [2,11], cause less decrease in uterine blood flow [2,11], or suppress spontaneous uterine contraction [17]. Except for its less analgesic action, propofol could be safer for pregnant animals as compared with the other induction agents.…”

Comparison of two pre-anaesthetic medetomidine doses in isoflurane anaesthetized sheep

“…This can in part be explained as a compensatory change occurring in response to lower systemic blood pressures caused by the higher propofol (Goodchild & Serrao 1989) and isoflurane (Bernards et al. 1997; Gaynor et al. 1998) doses required in the control group.…”

“…1985) caused by the higher MED dose and, or the lower propofol and isoflurane requirements (Goodchild & Serrao 1989); (Bernards et al. 1997; Gaynor et al. 1998).…”

Parâmetros Cardiopulmonares E Hemogasométricos Em Ovinos Sob Anestesia Inalatória Durante Alternâncias De Decúbito

“…Embora tenha ocorrido esta diminuição de aporte sanguíneo, houve associadamente um decréscimo do requerimento de oxigênio, não havendo comprometimento de órgãos vitais. Quando o isoflurano foi comparado ao propofol, um anestésico não volátil, em ovinos, verificou-se que o propofol em infusão contínua causa uma menor depressão cardiovascular em ovelhas gestantes, porém não há diferenças entre os dois fármacos no que concerne ao fluxo sanguíneo nas artérias umbilicais (5) . Além da estabilidade cardiopulmonar, a anestesia geral inalatória em ovinos é interessante por proporcionar uma recuperação anestésica rápida, diminuindo o risco de regurgitação, mas o uso de agentes injetáveis associados pode anular esta vantagem (6) .…”