A comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects

Barone, M.; Valle, N. Della; Rosania, Rosa; Facciorusso, Antonio; Trotta, A.; Cantatore, F. P.; Falco, Sandro De; Pignatiello, S; Viggiani, Maria Teresa; Аморусо, А.; Filippis, Renato de; Leo, Alfredo Di; Francavilla, Ruggiero

doi:10.1038/ejcn.2015.114

Cited by 87 publications

(84 citation statements)

References 28 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Concerning dietary fibers, Barone et al showed that CD patients consume less fibers compared to healthy adults. Similar findings were reached by other studies, both in adults and children [1,[4][5][6][7]. However, opposite findings were also reported [32][33][34].…”

Section: Discussionsupporting

confidence: 90%

“…A gluten-free diet (GFD) is vital for patients with coeliac disease (CD). However, it has been described as potentially unhealthy due to the extensive presence of fat and calories [1][2][3][4][5][6][7][8]. This extensive intake can change body mass index (BMI) and modify lipid profiles, with mixed results indicating potential early atherosclerosis development in adults and children, but also improvements in high-density lipoprotein (HDL) levels [9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gluten Deprivation: What Nutritional Changes Are Found During the First Year in Newly Diagnosed Coeliac Children?

et al. 2019

View full text Add to dashboard Cite

Aim: A gluten-free diet (GFD) can expose children to excessive calories and fat intake. The study is intended to verify whether and how food intake, laboratory parameters, and growth are modified by a year of GFD. Methods: In 79 CD (coeliac disease) children (mean age 7.9 ± 3.8 years, 52 females, 27 males) diagnosed over 24 months, 24-h food diaries, food-frequency patterns, anthropometric and laboratory parameters (mainly blood sugar, insulin, lipid profile, and homocysteine) were prospectively collected before and during the first year of GFD. Nutrient intakes were compared over time and with recommendations. They were also used as regressors to explain the levels and changes of metabolic and growth variables. p-values < 0.05 were considered statistically significant. Results: Average macronutrient intake did not change during the year. Caloric intake remained below 90% (p ≤ 0.0001) and protein intake above 200% (p ≤ 0.0001) of recommendations. Lipid intake was stable at 34% of overall energy intake. Unsaturated fats increased (less omega-6 and more omega-3 with a ratio improvement from 13.3 ± 5.5 to 8.8 ± 3.1) and so did fibers, while folate decreased. The children who experienced a containment in their caloric intake during the year, presented a slower catch-up growth. Some differences were found across gender and age groups. In particular, adolescents consumed less calories, and females more omega-3. Fiber and simple sugar intakes emerged as implicated in lipid profile shift: fibers negatively with triglycerides (TG) (p = 0.033), simple sugars negatively with high-density lipoprotein (HDL) (p = 0.056) and positively with TG (p = 0.004). Waist-to-height ratio was positively associated with homocysteine (p = 0.018) and Homeostasis Model Assessment (p = 0.001), negatively with fibers (p = 0.004). Conclusion: In the short run, GFD is nutritionally very similar to any diet with gluten, with some improvements in unsaturated fats and fiber intake. Along with simple sugars containment, this may offer CD patients the opportunity for a fresh start. Caloric intakes may shift and should be monitored, especially in adolescents.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Gluten Deprivation: What Nutritional Changes Are Found During the First Year in Newly Diagnosed Coeliac Children?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This diet is safe and can reduce the long‐term risk of serious complications, both neoplastic and non‐neoplastic . A GFD is related to increased lipid and carbohydrate intake. Moreover, many adults and children with CD become overweight after treatment .…”

Section: Introductionmentioning

confidence: 99%

Increased risk of nonalcoholic fatty liver disease in patients with coeliac disease on a gluten‐free diet: beyond traditional metabolic factors

Tovoli

Negrini

Farì

et al. 2018

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…Identifying genuinely wheat‐sensitive individuals is important because the gluten‐free diet has a number of potential disadvantages, including adverse effects on cardiovascular risk, higher rates of micronutrient deficiency, and even increased ingestion of toxins such as arsenic . That gluten avoidance improves weight control or general health is not supported by published evidence.…”

Section: Discussionmentioning

confidence: 99%

Incidence and prevalence of self‐reported non‐coeliac wheat sensitivity and gluten avoidance in Australia

Potter

Jones

Walker

et al. 2020

Medical Journal of Australia

View full text Add to dashboard Cite

Objectives To determine the incidence of self‐reported non‐coeliac wheat sensitivity (SR‐NCWS) and factors associated with its onset and resolution; to describe the prevalence of factors associated with gluten avoidance. Design Longitudinal cohort study; analysis of responses to self‐administered validated questionnaires (Digestive Health and Wellbeing surveys, 2015 and 2018). Setting, participants Subset of an adult population sample randomly selected in 2015 from the electoral rolls for the Newcastle and Gosford regions of New South Wales. Main outcome measures Prevalence of SR‐NCWS (2015, 2018) and incidence and resolution of SR‐NCWS, each by demographic and medical factors; prevalence of gluten avoidance and reasons for gluten avoidance (2018). Results 1322 of 2185 eligible participants completed the 2018 survey (response rate, 60.5%). The prevalence of SR‐NCWS was similar in 2015 (13.8%; 95% CI, 12.0–15.8%) and 2018 (13.9%; 95% CI, 12.1–15.9%); 69 of 1301 respondents (5.3%) reported developing new onset (incident) SR‐NCWS between 2015 and 2018 (incidence, 1.8% per year). Incident SR‐NCWS was significantly associated with a diagnosis of functional dyspepsia, and negatively associated with being male or older. Gluten avoidance was reported in 2018 by 24.2% of respondents (20.5% partial, 3.8% complete avoidance); general health was the most frequent reason for avoidance (168 of 316 avoiders, 53%). All 13 participants with coeliac disease, 56 of 138 with irritable bowel syndrome (41%), and 69 of 237 with functional dyspepsia (29%) avoided dietary gluten. Conclusions The prevalence of SR‐NCWS was similar in 2015 and 2018. Baseline (2015) and incident SR‐NCWS (2018) were each associated with functional gastrointestinal disorders. The number of people avoiding dietary gluten exceeds that of people with coeliac disease or SR‐NCWS, and general health considerations and abdominal symptoms are the most frequently reported reasons for avoidance.

show abstract

A comparison of the nutritional status between adult celiac patients on a long-term, strictly gluten-free diet and healthy subjects

Abstract: Our study demonstrates that a GFD is able to improve the nutritional status of celiac patients without inducing overweight or obesity. Our findings are related to a celiac population adopting a GFD based on a Mediterranean-type diet.

Cited by 87 publications

References 28 publications

Gluten Deprivation: What Nutritional Changes Are Found During the First Year in Newly Diagnosed Coeliac Children?

Gluten Deprivation: What Nutritional Changes Are Found During the First Year in Newly Diagnosed Coeliac Children?

Increased risk of nonalcoholic fatty liver disease in patients with coeliac disease on a gluten‐free diet: beyond traditional metabolic factors

Incidence and prevalence of self‐reported non‐coeliac wheat sensitivity and gluten avoidance in Australia

Contact Info

Product

Resources

About