A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish <i>Seriola lalandi</i>
 (Valenciennes, 1833)

Partridge, Gavin J.; Burge, T.S.; Lymbery, Alan J.

doi:10.1111/are.13010

Cited by 7 publications

(9 citation statements)

References 27 publications

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“…All of these treatments kill adult parasites, but leave the fish vulnerable to re-infection (Diggles et al, 1993; Yoshinaga et al ., 2000). Oral administration of the anthelmintic praziquantel has been tested to treat monogenean parasites infecting fish and is registered for use in Japan (Forwood et al, 2016); however, the drug affects the palatability of the feed and consequently the efficacy of the treatment (Partridge et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Plant extracts as a natural treatment against the fish ectoparasite Neobenedenia sp. (Monogenea: Capsalidae)

et al. 2017

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The toxicity of water-ethanol extracts of garlic (Allium sativum), ginger (Zingiber officinale), basil (Ocimum basilicum), bitter chaparro (Castela tortuousa), onion (Allium cepa) and papaya (Carica papaya) against adults, eggs and oncomiracidia of Neobenedenia spp. parasites was examined. Parasites were exposed to continuous immersion and treated as follows: extracts were tested at three dilutions: 1:10, 1:50 and 1:100 made with filtered seawater (35 g l-1); ethanol (70%) was evaluated at the same dilutions of 1:10 (7% ethanol), 1:50 (1.4% ethanol) and 1:100 (0.07% ethanol) and a seawater (35 g l-1) control. The antiparasitic effect was measured on: (1) adult survival, egg production and time to detachment from the culture vessel; (2) egg development and cumulative egg hatching; and (3) oncomiracidia survival. All three dilutions of ginger and dilutions 1:100 and 1:50 of basil extract reduced adult survival in vitro, time to detachment from the surface of the culture vessel, egg production and oncomiracidia survival. Bitter chaparro extract reduced adult egg production and oncomiracidia survival. Hatching success was significantly reduced (P < 0.05) in basil extract (1:100) to 86.6% compared to the seawater control (100%). Dilutions 1:10 of ginger and basil exhibited the highest impact on the biological parameters of Neobenedenia sp. Our study demonstrates that water-ethanol extracts of ginger, basil and bitter chaparro are toxic against Neobenedenia sp. life stages.

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Section: Introductionmentioning

confidence: 99%

Plant extracts as a natural treatment against the fish ectoparasite Neobenedenia sp. (Monogenea: Capsalidae)

et al. 2017

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“…To combat problems with palatability, preparations consisting of the (R)‐ enantiomer may be used instead of racemic mixtures since the (S)‐ enantiomer is responsible for the bitter taste, and only has limited anthelmintic properties (Meyer et al., ). However, this may not be the ultimate solution since the (R)‐ enantiomer has a stronger smell which decreased feed consumption at levels of 10 mg/Kg (Partridge, Burge, & Lymbery, ). Other methods have been investigated for masking the taste, including mixing with fish oil, krill extracts, sugar, or commercial fish attractants (Yamamoto, Shirakashi, Morimoto, Ishimaru, & Murata, ).…”

Section: Route Of Administrationmentioning

confidence: 99%

Use of praziquantel to control platyhelminth parasites of fish

Bader

Starling

Jones

et al. 2018

Vet Pharm & Therapeutics

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Fish are common definitive and intermediate hosts for a variety of parasitic flatworms. In unstressed wild populations, parasitic infections often go unnoticed and are perceived to represent a lesser threat to fish health. In contrast, platyhelminth parasitism of captive fish often results in decreased weight gain and increased mortality which often necessitates chemotherapeutic treatment. The presence of platyhelminth parasites in fish tissues is not only unappealing but in some cases also represents a threat to human health. In veterinary medicine, one of the most commonly used agents with anti‐flatworm activity is praziquantel; yet, no praziquantel products are labeled for use in fish in the United States. Veterinarians may use praziquantel preparations approved for other vertebrate species under the Animal Medicinal Drug Use Clarification Act (AMDUCA). However, such extra‐label use should be informed by scientific evidence including efficacy and tissue residue studies. Herein, we review studies testing the efficacy of praziquantel for treatment of platyhelminthes along with an assessment of routes of administration, pharmacokinetics, and toxicity information.

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“…Whilst oral (in-feed) delivery of PZQ can be highly efficacious, its strong bitter taste remains a major constraint to effective oral delivery in Seriola spp. (Hirazawa et al, 2013;Partridge et al, 2016;Williams et al, 2007) and other freshwater and marine fish species (Forwood et al, 2013;Hirazawa et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability and palatability of praziquantel incorporated into solid-lipid nanoparticles fed to yellowtail kingfish Seriola lalandi

Partridge

Rao

Woolley³

et al. 2019

Comparative Biochemistry and Physiology Part C: Toxicology &

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A comparison of the palatability of racemic praziquantel and its two enantioseparated isomers in yellowtail kingfish Seriola lalandi (Valenciennes, 1833)

Cited by 7 publications

References 27 publications

Plant extracts as a natural treatment against the fish ectoparasite Neobenedenia sp. (Monogenea: Capsalidae)

Plant extracts as a natural treatment against the fish ectoparasite Neobenedenia sp. (Monogenea: Capsalidae)

Use of praziquantel to control platyhelminth parasites of fish

Bioavailability and palatability of praziquantel incorporated into solid-lipid nanoparticles fed to yellowtail kingfish Seriola lalandi

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