A comprehensive<i>in silico</i>exploration of pharmacological properties, bioactivities and COX-2 inhibitory potential of eleutheroside B from<i>Eleutherococcus senticosus</i>(Rupr. &amp; Maxim.) Maxim.

Ahmed, Sium; Moni, Dil Afroj; Sonawane, Kailas D.; Paek, Kee Yoeup; Shohael, Abdullah Mohammad

doi:10.1080/07391102.2020.1803135

Cited by 27 publications

(11 citation statements)

References 72 publications

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“…Studies investigating Eleutheroside B and Eleutheroside E activity in humans are limited. However, according to data obtained from animal studies, they have great potential to be used for the treatment of inflammation, cancer, osteoporosis, and diabetes [ 172 , 180 , 181 , 182 , 183 , 184 ]. Studies investigating Eleutheroside B and Eleutheroside E activity in cell cultures are sparse [ 185 ].…”

Section: Resultsmentioning

confidence: 99%

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Todorova

Ivanov

Ivanova

2021

Plants

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Background: In the 1960s, research into plant adaptogens began. Plants with adaptogenic properties have rich phytochemical compositions and have been used by humanity since ancient times. However, it is not still clear whether the adaptogenic properties are because of specific compounds or because of the whole plant extracts. The aim of this review is to compare the bioactive compounds in the different parts of these plants. Methods: The search strategy was based on studies related to the isolation of bioactive compounds from Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus, and Panax ginseng. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Results: This review includes data from 259 articles. The phytochemicals isolated from Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus, and Panax ginseng were described and classified in several categories. Conclusions: Plant species have always played an important role in drug discovery because their effectiveness is based on the hundreds of years of experience with folk medicine in different nations. In our view, there is great potential in the near future for some of the phytochemicals found in these plants species to become pharmaceutical agents.

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Section: Resultsmentioning

confidence: 99%

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Todorova

Ivanov

Ivanova

2021

Plants

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“…The predicted cytotoxicity is represented by Pa and Pi values; if Pa > 0.5, the probability of cytotoxicity would be high (active), whereas Pi value represents inactivity. 28,50 The structures were submitted in SMILES format and subjected for evaluation of cytotoxicity using the CLC-Pred tool.…”

Section: Hplc-uv Analysis Of Characterised Compounds In Crude Methanolic Extracts Of a Nallamalayanamentioning

confidence: 99%

“…For the preliminary stage of drug development, computer-aided in silico strategies have become vital as they support more cost-effectively. [28][29][30] For the development of bioactive phytoconstituents, the global research scenario recommends using virtual screening methods/technology. 31 Prediction of possible pharmacological activity via in silico approach is based on the structure-activity relationship, which is usually correlated with the experimental data.…”

Section: Introductionmentioning

confidence: 99%

A comparative assessment ofin vitrocytotoxic activity and phytochemical profiling ofAndrographis nallamalayanaJ.L.Ellis andAndrographis paniculata(Burm. f.) Nees using UPLC-QTOF-MS/MS approach

et al. 2021

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“…Syringin and eleutheroside E are active ingredients isolated from AS. It has been proven that they have anti-fatigue, anti-oxidation, immune regulation and anti-inflammatory effects [ 9 , 10 , 11 , 12 , 13 ]. In addition, AS has also been shown to regulate the process of mediating the excitement and suppression of the central nervous system, and have a good therapeutic effect on related diseases that are caused by decreased learning and memory ability [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters

Song

Duan

et al. 2022

Molecules

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Acanthopanax senticosus (AS) is a medicinal and food homologous plant with many biological activities. In this research, we generated a brain injury model by 60Co -γ ray radiation at 4 Gy, and gavaged adult mice with the extract with AS, Acanthopanax senticocus polysaccharides (ASPS), flavones, syringin and eleutheroside E (EE) to explore the therapeutic effect and metabolic characteristics of AS on the brain injury. Behavioral tests and pathological experiments showed that the AS prevented the irradiated mice from learning and memory ability impairment and protected the neurons of irradiated mice. Meanwhile, the functional components of AS increased the antioxidant activity of irradiated mice. Furthermore, we found the changes of neurotransmitters, especially in the EE and syringin groups. Finally, distribution and pharmacokinetic analysis of AS showed that the functional components, especially EE, could exert their therapeutic effects in brain of irradiated mice. This lays a theoretical foundation for the further research on the treatment of radiation-induced brain injury by AS.

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A comprehensivein silicoexploration of pharmacological properties, bioactivities and COX-2 inhibitory potential of eleutheroside B fromEleutherococcus senticosus(Rupr. & Maxim.) Maxim.

Cited by 27 publications

References 72 publications

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

A comparative assessment ofin vitrocytotoxic activity and phytochemical profiling ofAndrographis nallamalayanaJ.L.Ellis andAndrographis paniculata(Burm. f.) Nees using UPLC-QTOF-MS/MS approach

The Therapeutic Effect of Acanthopanax senticosus Components on Radiation-Induced Brain Injury Based on the Pharmacokinetics and Neurotransmitters

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