A Comprehensive Review on PLGA-based Nanoparticles used for Rheumatoid Arthritis

Mohanty, Sandeep; Panda, Sthitapragnya; Purohit, Debashis; Chandra, Sudam

doi:10.5958/0974-360x.2019.00245.2

Cited by 7 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The encapsulation of enzymes into polymeric NPs offer several advantages compared to conventional enzyme-based therapy, including: (i) stabilizing and protecting the enzyme; (ii) improving biological activity; (iii) possibility of targeted delivery; (iv) controlling the enzyme release kinetics; (v) improving therapeutic efficacy and safety [10,35,36]. In particular, Poly(D,L-lactideco-glycolide) (PLGA), a U.S. Food and Drug Administration (FDA)-approved polymer that can self-assemble into NPs has been of high interest [37][38][39]. This is because it is capable of encapsulating large molecules such as proteins and enzymes [40][41][42][43][44] and has also been demonstrated to have the capacity to transport large cargo across the BBB by adding targeting ligands [2,[45][46][47].…”

Section: Introductionmentioning

confidence: 99%

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

et al. 2021

View full text Add to dashboard Cite

Enzymes, as natural and potentially long-term treatment options, have become one of the most sought-after pharmaceutical molecules to be delivered with nanoparticles (NPs); however, their instability during formulation often leads to underwhelming results. Various molecules, including the Tween® polysorbate series, have demonstrated enzyme activity protection but are often used uncontrolled without optimization. Here, poly(lactic-co-glycolic) acid (PLGA) NPs loaded with β-glucosidase (β-Glu) solutions containing Tween® 20, 60, or 80 were compared. Mixing the enzyme with Tween® pre-formulation had no effect on particle size or physical characteristics, but increased the amount of enzyme loaded. More importantly, NPs made with Tween® 20:enzyme solutions maintained significantly higher enzyme activity. Therefore, Tween® 20:enzyme solutions ranging from 60:1 to 2419:1 mol:mol were further analyzed. Isothermal titration calorimetry analysis demonstrated low affinity and unquantifiable binding between Tween® 20 and β-Glu. Incorporating these solutions in NPs showed no effect on size, zeta potential, or morphology. The amount of enzyme and Tween® 20 in the NPs was constant for all samples, but a trend towards higher activity with higher molar rapports of Tween® 20:β-Glu was observed. Finally, a burst release from NPs in the first hour with Tween®:β-Glu solutions was the same as free enzyme, but the enzyme remained active longer in solution. These results highlight the importance of stabilizers during NP formulation and how optimizing their use to stabilize an enzyme can help researchers design more efficient and effective enzyme loaded NPs.

show abstract

Section: Introductionmentioning

confidence: 99%

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

et al. 2021

View full text Add to dashboard Cite

show abstract

“…3−5 Among the BDSPs, PLGA is one of the most popular biodegradable polymers which has been industrialized and applied in various food, pharmaceutical, and biomedical industries. 6,7 Poly(lactic-co-glycolic acid) copolymers are generally synthesized by ring-opening copolymerization of lactic acid (LA) and glycolic acid (GA) cyclic dimers in the presence of catalysts such as aluminum isopropoxidem, tin(II) alkoxides, or tin(II) 2-ethylhexanoate. 8 Different PLGA copolymers may be achieved using different LA:GA ratios.…”

Section: Introductionmentioning

confidence: 99%

“…Polymers and their nanocomposites are used extensively in the contemporary biomedical arena because of their biocompatibility, biodegradability, cytotoxicity, and functionality. , Biodegradable synthetic polymers (BDSPs) such as poly( p -dioxanone) (PDOX), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and their copolymers such as poly(lactic- co -glycolic acid) (PLGA) have been widely exploited in biomedicine. − Among the BDSPs, PLGA is one of the most popular biodegradable polymers which has been industrialized and applied in various food, pharmaceutical, and biomedical industries. , …”

Section: Introductionmentioning

confidence: 99%

Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications

Zare‬

Jamaledin

Naserzadeh

et al. 2019

ACS Appl. Mater. Interfaces

143

View full text Add to dashboard Cite

Among the different synthetic polymers developed for biomedical applications, poly(lactic-co-glycolic acid) (PLGA) has attracted considerable attention because of its excellent biocompatibility and biodegradability. Nanocomposites based on PLGA and metal-based nanostructures (MNSs) have been employed extensively as an efficient strategy to improve the structural and functional properties of PLGA polymer. The MNSs have been used to impart new properties to PLGA, such as antimicrobial properties and labeling. In the present review, the different strategies available for the fabrication of MNS/PLGA nanocomposites and their applications in the biomedical field will be discussed, beginning with a description of the preparation routes, antimicrobial activity, and cytotoxicity concerns of MNS/PLGA nanocomposites. The biomedical applications of these nanocomposites, such as carriers and scaffolds in tissue regeneration and other therapies are subsequently reviewed. In addition, the potential advantages of using MNS/PLGA nanocomposites in treatment illnesses are analyzed based on in vitro and in vivo studies, to support the potential of these nanocomposites in future research in the biomedical field.

show abstract

“…Using a zeta sizer, the nanoparticles' zeta potential was ascertained. 36,37 Morphological study of PLGA based nanoparticles A scanning electron microscope was used to look at the shape of PLGA nanoparticles that were filled with rifampicin and ascorbic acid. To make samples, particle suspensions were diluted in distilled water and then stuck to pieces with doublesided tape.…”

Section: Preparation Of Plga Based Nanoparticlesmentioning

confidence: 99%

Preparation and Evaluation of PLGA-based Nanoparticles

Choudhary,

Kumar,

Kommineni

et al. 2023

IJDDT

View full text Add to dashboard Cite

The current study aimed to increase the stability and therapeutic efficacy of the antitubercular medication rifampicin by reducing or preventing its breakdown in the stomach pH state. Ascorbic acid was used as an antioxidant in the preparation of rifampicin-loaded Poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the investigation. A multistep emulsion process was used to create dig-laden nanoparticles, and different techniques were then used to assess the final product. Ten different kinds of formulations were created for this study. According to the study’s findings, ascorbic acid can increase rifampicin’s stability and bioavailability by reducing its breakdown in acidic pH conditions. The results also show that changing the ascorbic acid concentration makes a statistically important difference in the way the medicine breaks down.

show abstract

A Comprehensive Review on PLGA-based Nanoparticles used for Rheumatoid Arthritis

Cited by 7 publications

References 0 publications

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

Tween® Preserves Enzyme Activity and Stability in PLGA Nanoparticles

Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications

Preparation and Evaluation of PLGA-based Nanoparticles

Contact Info

Product

Resources

About