The invention of newer chemical entities, which have some therapeutically worth is always a great challenge. It is no doubt that it is a lengthier process. We have several drugs in the market for treatment of wide variety of diseases. The marketed drugs available may be heterocyclic or non-heterocyclic derivatives. Always it was found that heterocyclic derivatives have wide variety of pharmacological activity. The intension of this review is to highlight one of the important heterocyclic rings i.e.: Morpholine. Several works have been done on this nucleus, which should be enlighten for more and more applicability.

The current COVID-19 epidemic caused by the new SARS-CoV-2 has severely harmed global healthcare (severe acute respiratory syndrome coronavirus). COVID-19's pulmonary and cardiovascular effects have been known from its inception, but its causes, mechanisms, and neuropath logical consequences remain unknown. Our research focused on neurological problems in COVID-19 patients, as well as probable SARS-CoV-2 infection routes like hematogenous, direct/neuronal, lymphatic tissue, cerebrospinal fluid, or infiltration by infected immune cells. Late December 2019 in Wuhan, China, a mysterious viral pneumonia struck. The disease was caused by a new corona virus. Corona virus infection spread rapidly from person to person in 2019. The WHO has called it a global public health emergency (WHO). Activation of NF-B in SARS-CoV-2 infection may be linked to immune cell pathogenicity, cytokine storms, and multi-organ failure. COVID-19's inhibition of the NF-B signaling pathway shows promising therapeutically. Inhibiting IKK phosphorylation, a critical downstream consequence of the NF-B signaling cascade, reduces COVID-19 levels. All three disorders have been linked to COVID-19 gene mutations. This study provides a biological basis for future research on COVID-19-related neurological disease. W

Acne is one of the most common chronic inflammatory dermatological disorder associated with multifactorial pathogenesis. Approximately 95 % of the population suffers from it at some point in their lifetime. Antibiotics, acids, benzoyl peroxide, and retinoids are the most commonly drugs used for the treatment of acne. However, conventional formulations of these drugs are associated with undesirable toxicities, inadequate penetration across stratum corneum, short retention time of the drug in the target site, and poor aqueous solubility of drugs, that limited their medicinal applications. As a consequence pharmaceutical researchers are turning towards novel drug delivery systems to overcome these limitations.With respect to their small particle size, lipid occlusive nature and unique surface characteristics, lipid nanocarriers can promote skin hydration, enhance drug permeation, improve its targeting properties and retention time on the skin, increase drug solubility and protect it from degradation, provide sustained drug release and reduce dosing frequency. The current review summarizes the better nanotechnological systems that can be used in future for better and effective treatment of acne.

Acne is one of the most common chronic inflammatory dermatological disorder associated with multifactorial pathogenesis. Approximately 95 % of the population suffers from it at some point in their lifetime. Antibiotics, acids, benzoyl peroxide, and retinoids are the most commonly drugs used for the treatment of acne. However, conventional formulations of these drugs are associated with undesirable toxicities, inadequate penetration across stratum corneum, short retention time of the drug in the target site, and poor aqueous solubility of drugs, that limited their medicinal applications. As a consequence pharmaceutical researchers are turning towards novel drug delivery systems to overcome these limitations.With respect to their small particle size, lipid occlusive nature and unique surface characteristics, lipid nanocarriers can promote skin hydration, enhance drug permeation, improve its targeting properties and retention time on the skin, increase drug solubility and protect it from degradation, provide sustained drug release and reduce dosing frequency. The current review summarizes the better nanotechnological systems that can be used in future for better and effective treatment of acne.

No abstract