A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities

He, Haiyan; Ma, Yao‐Ying; Huang, Haoyue; Huang, Chao; Chen, Zhuo; Chen, Dongjian; Gu, Yiming; Wang, Xiaohua; Chen, Jinliang

doi:10.1016/j.ejphar.2020.173803

Cited by 22 publications

(23 citation statements)

References 162 publications

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“…Garlic, as a food that is often consumed daily, is also a longstanding commonly used Chinese folk medicine. The effective ingredient in garlic is diallyl disulfide (DADS), also known as allicin, which can exert antifungal, antibacterial, and antitumor effects and ameliorate cardiovascular disease (Yi and Su, 2013;He et al, 2021). The antifungal effect of DADS against C. albicans involves the inhibition of biofilm formation by preventing the conversion of yeast to hyphae (Khodavandi et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice

Huang

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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Diallyl disulfide (DADS), a garlic extract also known as allicin, has been reported to have numerous biological activities, including anticancer, antifungal, and inflammation-inhibiting activities, among others. Although many studies have assessed whether DADS can treat Candida albicans infection in vitro, its in vivo function and the underlying mechanism are still not clear. Accumulated evidence has implicated the gut microbiota as an important factor in the colonization and invasion of C. albicans. Thus, this study aimed to identify the mechanism by which DADS ameliorates dextran sulfate (DSS)-induced intestinal C. albicans infection based on the systematic analysis of the gut microbiota and metabolomics in mice. Here, we determined the body weight, survival, colon length, histological score, and inflammatory cytokine levels in the serum and intestines of experimental mice. Fecal samples were collected for gut microbiota and metabolite analysis by 16S rRNA gene sequencing and LC–MS metabolomics, respectively. DADS significantly alleviated DSS-induced intestinal C. albicans infection and altered the gut microbial community structure and metabolic profile in the mice. The abundances of some pathogenic bacteria, such as Proteobacteria, Escherichia–Shigella, and Streptococcus, were notably decreased after treatment with DADS. In contrast, SCFA-producing bacteria, namely, Ruminiclostridium, Oscillibacter, and Ruminococcaceae_UCG−013, greatly increased in number. The perturbance of metabolites in infectious mice was improved by DADS, with increases in secondary bile acids, arachidonic acid, indoles and their derivatives, which were highly related to the multiple differentially altered metabolic pathways, namely, bile secretion, arachidonic acid metabolism, and tryptophan metabolism. This study indicated that DADS could modulate gut microbiota and metabolites and protect the gut barrier to alleviate DSS-induced intestinal C. albicans infection in mice. Moreover, this work might also provide novel insight into the treatment of C. albicans infection using DADS.

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Section: Introductionmentioning

confidence: 99%

Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice

Huang

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Similarly, Mandlik and Namdeo [127] showed that numerous studies have reported the neuroprotective effects and pivotal role in the prevention and treatment of several kinds of cancers (e.g., breast, renal, lung cancers) of Withania somnifera. Diallyl disulfide (DADS) is one of the major volatile degradative garlic compounds and some neuroprotective effects in animal models of AD and anticancer (e.g., inhibition of oxidative stress, cellular apoptosis, angiogenesis, and GSK-3β/NF-κB-associated signaling) has been also established [128]. These results conducive to conclude that the development of new drugs which target for both disorders is possible.…”

Section: Spirochaetesmentioning

confidence: 95%

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

et al. 2021

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The negative association between Alzheimer’s disease (AD) and cancer suggests that susceptibility to one disease may protect against the other. When biological mechanisms of AD and cancer and relationship between them are understood, the unsolved problem of both diseases which still touches the growing human population could be overcome. Actual information about biological mechanisms and common risk factors such as chronic inflammation, age-related metabolic deregulation, and family history is presented here. Common signaling pathways, e.g., p53, Wnt, role of Pin1, and microRNA, are discussed as well. Much attention is also paid to the potential impact of chronic viral, bacterial, and fungal infections that are responsible for the inflammatory pathway in AD and also play a key role to cancer development. New data about common mechanisms in etiopathology of cancer and neurological diseases suggests new therapeutic strategies. Among them, the use of nilotinib, tyrosine kinase inhibitor, protein kinase C, and bexarotene is the most promising.

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“…It should be noted that there are some non-negligible issues that need to be solved before conducting clinical trials of DADS. e first is that DADS is rapidly metabolized after being taken into the body and has low bioavailability [6]. e second is the technical difficulties of processing DADS, such as characterization, optimization, and the production of suitable delivery systems [174,175].…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

“…It is believed that organic sulfur compounds are responsible for most of the biological activities of garlic [5]. Diallyl disulfide (DADS; structure: two sulfur atoms with two allyl groups; see Figure 1) is a major organosulfur compound of garlic [6,7]. Studies have shown that DADS has many biological functions, including antiinflammatory, antioxidant, anticancer, and detoxifying effects, which may be determined by its chemical structure [4,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that DADS has many biological functions, including antiinflammatory, antioxidant, anticancer, and detoxifying effects, which may be determined by its chemical structure [4,[7][8][9]. Previous reviews have discussed the promising value of DADS in the prevention and treatment of a wide range of diseases [6]. In this work, we performed a systematic review of the biological functions of DADS based on the cellular and molecular mechanisms, hoping to provide an updated scientific basis and insight for future experiments.…”

Section: Introductionmentioning

confidence: 99%

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Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound

Song

Yue

Nie

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Garlic is widely accepted as a functional food and an excellent source of pharmacologically active ingredients. Diallyl disulfide (DADS), a major bioactive component of garlic, has several beneficial biological functions, including anti-inflammatory, antioxidant, antimicrobial, cardiovascular protective, neuroprotective, and anticancer activities. This review systematically evaluated the biological functions of DADS and discussed the underlying molecular mechanisms of these functions. We hope that this review provides guidance and insight into the current literature and enables future research and the development of DADS for intervention and treatment of multiple diseases.

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A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities

Cited by 22 publications

References 162 publications

Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice

Diallyl Disulfide (DADS) Ameliorates Intestinal Candida albicans Infection by Modulating the Gut microbiota and Metabolites and Providing Intestinal Protection in Mice

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound

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