A Computational Model for Drug Release from PLGA Implant

Milošević, Marija; Stojanović, Dušica; Simić, Vladimir; Milićević, Bogdan; Radisavljevic, Andjela; Uskoković, Dragan; Kojić, Miloš

doi:10.3390/ma11122416

Cited by 22 publications

(21 citation statements)

References 29 publications

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“…4-6. A slow release of RhB from uniaxial PLGA (50:50) fibers has been reported earlier 48,49 . A higher release of BSA-FITC from uniaxial fibers in comparison with RhB was due to its higher solubility in water 50 .…”

Section: Discussionsupporting

confidence: 56%

“…A higher release of BSA-FITC from core with comparison to RhB from sheath of coaxial fibers was due to the increase in hydrophilicity and water retention. Hydrophilicity and water retention play an important role in drug release kinetics 48,51 . In case of coaxial and triaxial electrospun fibers, the addition of RhB in the sheath increased the water retention capacity of the sheath concurrently leading to a higher release of BSA-FITC from core/intermediate layers.…”

Section: Discussionmentioning

confidence: 99%

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Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications

Nagiah

Murdock

Bhattacharjee

et al. 2020

Sci Rep

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Since the first work by Laurencin and colleagues on the development of polymeric electrospinning for biomedical purposes, the use of electrospinning technology has found broad applications in such areas of tissue regeneration and drug delivery. More recently, coaxial electrospinning has emerged as an important technique to develop scaffolds for regenerative engineering incorporated with drug(s). However, the addition of a softer core layer leads to a reduction in mechanical properties. Here, novel robust tripolymeric triaxially electrospun fibrous scaffolds were developed with a polycaprolactone (PCL) (core layer), a 50:50 poly (lactic-co-glycolic acid) (PLGA) (sheath layer) and a gelatin (intermediate layer) with a dual drug delivery capability was developed through modified electrospinning. A sharp increase in elastic modulus after the incorporation of PCL in the core of the triaxial fibers in comparison with uniaxial PLGA (50:50) and coaxial PLGA (50:50) (sheath)-gelatin (core) fibers was observed. Thermal analysis of the fibrous scaffolds revealed an interaction between the core-intermediate and sheath-intermediate layers of the triaxial fibers contributing to the higher tensile modulus. A simultaneous dual release of model small molecule Rhodamine B (RhB) and model protein Fluorescein isothiocynate (FITC) Bovine Serum Albumin (BSA) conjugate incorporated in the sheath and intermediate layers of triaxial fibers was achieved. The tripolymeric, triaxial electrospun systems were seen to be ideal for the support of mesenchymal stem cell growth, as shrinkage of fibers normally found with conventional electrospun systems was minimized. These tripolymeric triaxial electrospun fibers that are biomechanically competent, biocompatible, and capable of dual drug release are designed for regenerative engineering and drug delivery applications.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications

Nagiah

Murdock

Bhattacharjee

et al. 2020

Sci Rep

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“…Comparison with other available numerical solutions in literature, such as those related to one domain only (e.g., tumor), would be possible with imposing the appropriate boundary conditions in our smeared model. This is not done here, since accuracy of our smeared models was examined in detail in our previous references (Kojic et al, 2017a(Kojic et al, ,b, 2018(Kojic et al, , 2019Milosevic et al, 2018b).…”

Section: Discussionmentioning

confidence: 99%

“…The above concept has been implemented for diffusion and fluid transport through complex systems consisting of capillary network and tissue, with inclusion of the hydrophobicity effects in the connectivity elements (Kojic et al, 2014(Kojic et al, , 2017a(Kojic et al, , 2018, and with improvements of accuracy of the smeared methodology achieved by the correction function introduced in Milosevic et al (2018a). The robustness and applicability of the smeared model are demonstrated (Milosevic et al, 2018b), where the CSFE is extended for modeling drug release from a complex mesh of drug-loaded nanofibers.…”

Section: Smeared Model For Field Problemsmentioning

confidence: 99%

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics

Kojić

Milošević

Simić

et al. 2019

Front. Bioeng. Biotechnol.

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Mass transport represents the most fundamental process in living organisms. It includes delivery of nutrients, oxygen, drugs, and other substances from the vascular system to tissue and transport of waste and other products from cells back to vascular and lymphatic network and organs. Furthermore, movement is achieved by mechanical forces generated by muscles in coordination with the nervous system. The signals coming from the brain, which have the character of electrical waves, produce activation within muscle cells. Therefore, from a physics perspective, there exist a number of physical fields within the body, such as velocities of transport, pressures, concentrations of substances, and electrical potential, which is directly coupled to biochemical processes of transforming the chemical into mechanical energy and further internal forces for motion. The overall problems of mass transport and electrophysiology coupled to mechanics can be investigated theoretically by developing appropriate computational models. Due to the enormous complexity of the biological system, it would be almost impossible to establish a detailed computational model for the physical fields related to mass transport, electrophysiology, and coupled fields. To make computational models feasible for applications, we here summarize a concept of smeared physical fields, with coupling among them, and muscle mechanics, which includes dependence on the electrical potential. Accuracy of the smeared computational models, also with coupling to muscle mechanics, is illustrated with simple example, while their applicability is demonstrated on a liver model with tumors present. The last example shows that the introduced methodology is applicable to large biological systems.

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“…al 2016b, 2017a, 2017b, 2017c, Milosevic et. al 2018a, 2018b. In this paper we summarize the previous work in a way to present the methodology as general, with appropriate generalized mathematical expressions, for the field problems in composite media.…”

Section: Introductionmentioning

confidence: 99%

Smeared Concept as a General Methodology in Finite Element Modeling of Physical Fields and Mechanical Problems in Composite Media

Kojić¹

2018

JSSCM

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A generalization of the smeared concept for field problems, published in recent papers of the author and his collaborators, is presented in the paper. A composite smeared finite element CSFE is formulated. This generalization can serve as a theoretical background for further applications. A selected numerical example, related to convective-diffusive mass transport within a cancerous tissue, illustrates efficiency and accuracy of the smeared models. Further, a smeared methodology is extended to mechanical problems. A theoretical background is given in detail, with introducing a composite smeared finite element for mechanics CSFEM, which can further be tested and modified. Finally, a consistent derivation is presented for the continuum constitutive tensor corresponding to a fibrous structure.

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A Computational Model for Drug Release from PLGA Implant

Cited by 22 publications

References 29 publications

Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications

Development of Tripolymeric Triaxial Electrospun Fibrous Matrices for Dual Drug Delivery Applications

Smeared Multiscale Finite Element Models for Mass Transport and Electrophysiology Coupled to Muscle Mechanics

Smeared Concept as a General Methodology in Finite Element Modeling of Physical Fields and Mechanical Problems in Composite Media

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