A conducive bioceramic/polymer composite biomaterial for diabetic wound healing

Lv, Fang; Wang, Jie; Xu, Peng; Han, Yiming; Ma, Haitao; He, Xu; Chen, Shijie; Chang, Jiang; Ke, Qinfei; Liu, Mingyao; Yi, Zhengfang; Wu, Chengtie

doi:10.1016/j.actbio.2017.07.020

Cited by 148 publications

(105 citation statements)

References 57 publications

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“…Scar formation is a pathogenesis of the dermis characteristic of the overcompensation of wound defect. In previous studies, PCL/gelatin nanofiber scaffolds distinctly induced the angiogenesis, collagen deposition and re-epithelialization in the wound site in diabetic mouse model, as well as inhibited the inflammation reaction [42]. Although PCL/gelatin nanofiber scaffolds provide great potential in the treatment of dermal wounds [24], the effects of fibrous scaffold on scar formation and the underlying mechanism that regulating fibrosisassociated ECM molecules remain elusive.…”

Section: Discussionmentioning

confidence: 97%

Nanofiber scaffolds attenuate collagen synthesis of human dermal fibroblasts through TGF-β1/TSG-6 pathway*

et al. 2019

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Nanofiber scaffolds are promising patches for skin tissue regeneration as they provide favorable environment for the adhesion, infiltration and proliferation of skin dermal fibroblasts. However, the effects of nanofiber scaffolds on scar formation remain to be elucidated. The aim of this study was to find out the relationship between nanofiber scaffolds and scar formation, along with the underlying mechanism. We found that polycaprolactone (PCL)/gelatin nanofiber scaffolds attenuated the mRNA expression of fibrosis-associated genes in fibroblasts, including collagen I (collagen type I alpha 1), collagen III (collagen type III alpha 1) and fibronectin. Specifically thicker scaffolds displayed stronger fibrosis inhibitory effect than thin scaffolds. The mechanism relied on TGF-β1/TSG-6 pathway, and overexpression of TSG-6 impaired the anti-fibrosis effect of nanofiber scaffolds, which decreased TGF-β1 expression with thickness-dependency. Moreover, in vivo study demonstrated that nanofiber scaffolds remarkably accelerated the wound healing process by reducing the ratios of collagen I/ collagen III and TGF-β1, eventually decreased the deposition of collagens. Taken together, our results suggested that the attenuation of fibrosis by PCL/gelatin nanofiber scaffolds was TGF-β1-dependent and through TGF-β1/TSG-6 pathway. Nanofiber scaffold of appropriate thickness would accelerate skin wound healing, stimulate re-epithelialization and form cutaneous skin appendages in skin trauma. Thus, PCL/gelatin nanofiber scaffolds could be adopted for scar-free skin wound healing and skin cosmetics applications.

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Section: Discussionmentioning

confidence: 97%

Nanofiber scaffolds attenuate collagen synthesis of human dermal fibroblasts through TGF-β1/TSG-6 pathway*

et al. 2019

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“…1b) [67] and significantly enhance angiogenesis differentiation [68]. Typically, the parallel-aligned nanofiber can be collected with the aid of a high-speed rotating drum or conductive plates separated by a void gap [69]. For example, Li et al [70] have fabricated a kind of aligned poly(l-lactic acid) (PLLA) electrospun fibrous membrane by elevating the rotating speed of collecting drum, and a promotion in cell infiltration was obtained in vitro and an improvement in migration of epidermal skin cells across the wound was achieved in vivo for aligned PLLA nanofibers.…”

Section: D Nanofibrous Membranesmentioning

confidence: 99%

Electrospun Nanofibrous Materials for Wound Healing

et al. 2020

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Wound dressing materials which are capable of meeting the demands of accelerating wound closure and promoting wound healing process have being highly desired. Electrospun nanofibrous materials show great application potentials for wound healing owing to relatively large surface area, better mimicry of native extracellular matrix, adjustable waterproofness and breathability, and programmable drug delivery process. In this review article, we begin with a discussion of wound healing process and current commercial wound dressing materials. Then, we emphasize on electrospun nanofibrous materials for wound dressing, covering the efforts for controlling fiber alignment and morphology, constructing 3D scaffolds, developing waterproof-breathable membrane, governing drug delivery performance, and regulating stem cell behavior. Finally, we finish with challenges and future prospects of electrospun nanofibrous materials for wound dressings.

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“…Apart from the feasible implementation in acute infections of wound sites, electrospun scaffolds are able to sustainably release therapeutic agents and simultaneously support in situ tissue regeneration for curing chronic wound diseases, such as diabetic wound diseases . Various drug‐loaded scaffolds were designed to improve the poor angiogenesis and delayed wound closure in diabetic wounds associated with high blood glucose level, and therefore to achieve accelerated diabetic wound healing.…”

Section: Applications In Biomedical Fieldsmentioning

confidence: 99%

“…Ren et al[145b] developed a composite scaffold consisting of both beneficial micro/nanostructural cues and chemical active agents to create a synergistic microenvironment for rapid diabetic wound healing ( Figure ). It was observed that nanopores enhanced the protein adsorption, and thus, the cellular adhesion and proliferation, and the aligned fibers favorably regulated the endothelial cellular angiogenesis differentiation.…”

Section: Applications In Biomedical Fieldsmentioning

confidence: 99%

“…Studies focusing on the other aspects of wound healing were also reported. Cheng et al[29d] encapsulated a bioactive drug 20(R)‐ginsenoside RG3 onto PLGA fibers through pDA coating, and then further immobilized bFGF onto fibers surfaces to inhibit the formation of hypertrophic scars during wound healing process. Dong et al created a handy electrospinning device to fabricate antibacterial PCL membranes, which reduced the inflammation and promoted the wound healing in vivo.…”

Section: Applications In Biomedical Fieldsmentioning

confidence: 99%

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Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

Ding

Zhang

et al. 2018

Adv Funct Materials

217

138

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The versatile electrospinning technique is recognized as an efficient strategy to deliver active pharmaceutical ingredients and has gained tremendous progress in drug delivery, tissue engineering, cancer therapy, and disease diagnosis. Numerous drug delivery systems fabricated through electrospinning regarding the carrier compositions, drug incorporation techniques, release kinetics, and the subsequent therapeutic efficacy are presented herein. Targeting for distinct applications, the composition of drug carriers vary from natural/synthetic polymers/blends, inorganic materials, and even hybrids. Various drug incorporation approaches through electrospinning are thoroughly discussed with respect to the principles, benefits, and limitations. To meet the various requirements in actual sophisticated in vivo environments and to overcome the limitations of a single carrier system, feasible combinations of multiple drug-inclusion processes via electrospinning could be employed to achieve programmed, multi-staged, or stimuli-triggered release of multiple drugs. The therapeutic efficacy of the designed electrospun drugeluting systems is further verified in multiple biomedical applications and is comprehensively overviewed, demonstrating promising potential to address a variety of clinical challenges.

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A conducive bioceramic/polymer composite biomaterial for diabetic wound healing

Cited by 148 publications

References 57 publications

Nanofiber scaffolds attenuate collagen synthesis of human dermal fibroblasts through TGF-β1/TSG-6 pathway*

Nanofiber scaffolds attenuate collagen synthesis of human dermal fibroblasts through TGF-β1/TSG-6 pathway*

Electrospun Nanofibrous Materials for Wound Healing

Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy

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