A Controlled, Double-Blind Study of dl-Alpha-Tocopheryl Nicotinate (Juvela-Nicotinate&lt;sup&gt;®&lt;/sup&gt;) for Treatment of Symptoms in Hypertension and Cerebral Arteriosclerosis

Iino, Kohzoh; Abe, Ken; Kariya, Sumito; Kimura, Hiroyuki; Kusaba, Tadashi; Kusunoki, Ryoji; Saku, Junichi; Soejima, Kuninori; Nakakura, Shigeo; Nakamura, Isao; Nakamura, Kazunori; Nakayama, Yuhki; Notomi, Akimitsu; Hamada, Masaaki; Miyazaki, Tadashi; Furukawa, I

doi:10.1536/ihj.18.277

Cited by 18 publications

(7 citation statements)

References 4 publications

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“…Iino et al conducted a controlled, double-blind trial of Juvela-N (α-tocopheryl nicotinate) versus the placebo for the relief of subjectively assessed symptoms in patients with hypertension and cerebral atherosclerosis [39]. A total of 94 subjects were given either 600 mg/day of α-tocopheryl nicotinate or 600 mg/day of the inactive placebo, administered orally in six capsules, for 4 to 6 weeks, and 89 subjects completed the trial (44 in the α-tocopheryl nicotinate-treated group and 45 in the placebo group).…”

Section: Cardiovascularmentioning

confidence: 99%

Vitamin E Nicotinate

Duncan

Suzuki

2017

Antioxidants

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Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications. The forms of vitamin E most studied are natural α-tocopherol and the esters α-tocopheryl acetate and α-tocopheryl succinate. A small number of studies include or focus on another ester form, α-tocopheryl nicotinate, an ester of vitamin E and niacin. Some of these studies raise the possibility of differences in metabolism and in efficacy between vitamin E nicotinate and other forms of vitamin E. Recently, through metabolomics studies, we identified that α-tocopheryl nicotinate occurs endogenously in the heart and that its level is dramatically decreased in heart failure, indicating the possible biological importance of this vitamin E ester. Since knowledge about vitamin E nicotinate is not readily available in the literature, the purpose of this review is to summarize and evaluate published reports, specifically with respect to α-tocopheryl nicotinate with an emphasis on the differences from natural α-tocopherol or α-tocopheryl acetate.

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Section: Cardiovascularmentioning

confidence: 99%

Vitamin E Nicotinate

Duncan

Suzuki

2017

Antioxidants

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“…Therefore, 4 trials that reported only on the indirect outcome of lipid oxidation were excluded from pooling 42–45 . A fifth trial 46 was excluded because none of the chosen lipid outcomes was identified. A sixth trial 47 was excluded because it was a pharmacokinetics study of coenzyme Q10.…”

Section: Resultsmentioning

confidence: 99%

Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease

et al. 2004

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“…Vitamin E, being lipid soluble, is found in the body within the cellular and subcellular membrane phospholipids [14,104]. Dietary supplementation with vitamin E significantly lowers blood pressure in various rat models of essential hypertension including SHRs [105][106][107][108][109][110][111] (Figure 4) In three studies that examined the antihypertensive effect of vitamin E alone in human essential hypertensives, two reported that it lowered systolic blood pressure, while a third showed a reduction in both systolic and diastolic blood pressures [112][113][114] (Table 4). Vitamin E levels are lower in essential hypertensive patients [6,7] and in spontaneously hypertensive rats compared with their normotensive counterparts [74,68,115].…”

Section: Vitamin B6mentioning

confidence: 99%

“…Vasdev et al [111] Humans with hypertension and with hypertension and cerebral arteriosclerosis 600 mg/day oral dose for 4-6 weeks Lowered systolic, but not diastolic, blood pressure Iino et al [112] Humans with mild essential hypertension Spontaneously hypertensive rats 1 and 10 mg/kg body wt/day oral dose for 3 weeks Delayed onset of hypertension but no significant difference after 3 weeks of treatment in young animals (14-17 wks); 10-mg dose lowered systolic blood pressure in older animals (21-25 wks)…”

Section: Attenuated An Increase In Blood Pressurementioning

confidence: 99%

Antioxidants in the treatment of hypertension

Vasdev

Gill

2011

Int J Angiol

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Hypertension is a major health problem worldwide. Individuals with hypertension are at an increased risk for stroke, heart disease, and kidney failure. Although the etiology of essential hypertension has a genetic component, lifestyle factors such as diet play an important role. Insulin resistance and glucose intolerance are common features of hypertension in humans and in animal models. Altered glucose metabolism leads to an increased production of the reactive aldehyde, methylglyoxal. Methylglyoxal binds sulfhydryl and amino groups of proteins forming conjugates/advanced glycation end products (AGEs). This alters protein structure and function and can affect vascular calcium channels, enzymes, and tissue proteins leading to increased oxidative stress. These alterations impair endothelial function leading to an increase in intracellular free calcium, peripheral vascular resistance, and hypertension. Supplementation with antioxidants, including vitamin C, E, or B6, thiols such as lipoic acid and cysteine, and the quinone enzyme Q10, have been shown to lower blood pressure in animal models and humans with essential hypertension. The Dietary Approaches to Stop Hypertension (DASH) studies demonstrated that a wellbalanced diet, rich in these nutrients, was effective in lowering blood pressure. These antioxidants may achieve their antihypertensive effects by reducing aldehyde conjugate/AGE formation and oxidative stress, by improving insulin resistance and endothelial function, or by normalizing calcium channels and peripheral vascular resistance. In essential hypertension, deficiencies of antioxidants may exist or a higher than normal amount may be required to correct metabolic abnormalities. Dietary supplementation with antioxidants may be a beneficial, inexpensive, first-line alternate treatment modality for hypertension.

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A Controlled, Double-Blind Study of dl-Alpha-Tocopheryl Nicotinate (Juvela-Nicotinate<sup>®</sup>) for Treatment of Symptoms in Hypertension and Cerebral Arteriosclerosis

Cited by 18 publications

References 4 publications

Vitamin E Nicotinate

Vitamin E Nicotinate

Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease

Antioxidants in the treatment of hypertension

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