A core–shell structured polyplex for efficient and non-toxic gene delivery

Wang, Saisai; Wang, Fei; Zhang, Qiang; Cheng, Yiyun

doi:10.1039/c7tb00690j

Cited by 11 publications

(8 citation statements)

References 47 publications

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“…PAMAM dendrimers [ 177 , 178 , 179 ], phosphoric dendrimers [ 180 , 181 ], PPI dendrimers [ 182 , 183 ] are among the most-used dendrimers in GDEPT. Figure 8 presents the most-used dendrimers for the delivery of therapeutic genes [ 182 ].…”

Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

et al. 2021

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Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug. In recent years, numerous therapeutic systems based on GDEPT strategy have entered clinical trials. In order to deliver the desired gene at a specific site of action, this therapeutic approach uses vectors divided in two major categories, viral vectors and non-viral vectors, with the latter being represented by chemical delivery agents. There is considerable interest in the development of non-viral vectors due to their decreased immunogenicity, higher specificity, ease of synthesis and greater flexibility for subsequent modulations. Dendrimers used as delivery vehicles offer many advantages, such as: nanoscale size, precise molecular weight, increased solubility, high load capacity, high bioavailability and low immunogenicity. The aim of the present work was to provide a comprehensive overview of the recent advances regarding the use of dendrimers as non-viral carriers in the GDEPT therapy.

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Section: Dendrimers In Gdept Strategymentioning

confidence: 99%

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

et al. 2021

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“…Breaking up the correlation between transfection efficacy and cytotoxicity for dendrimer-based gene delivery system is urgent. In addition to the functional modification of dendrimers [18,114,115], SDNs has been considered as one of the alternative solutions for highly efficient gene transfection with low toxicity. As demonstrated by Liu et al [56], the G2 PAMAM dendrimers were utilized to obtain G2 NCs crosslinked with disulfide bond.…”

Section: Gene Deliverymentioning

confidence: 99%

Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review

Song

Shen

Rodrigues

et al. 2020

Coordination Chemistry Reviews

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“…Because of the lack of tertiary amine groups in their structures, PEI promoted DNA release from the polyplex. Furthermore, the hydrophobic nature of PEI might facilitate the escape of the polyplex from the endosome [262].…”

Section: Gene Deliverymentioning

confidence: 99%

Nanocomposites as biomolecules delivery agents in nanomedicine

Bamburowicz-Klimkowska

Popławska

Grudziński

2019

J Nanobiotechnol

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Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess unique physical and chemical properties associated with a size range of between 1 and 100 nm. Their nano-sized dimensions, which are in the same range as those of vital biomolecules, such as antibodies, membrane receptors, nucleic acids, and proteins, allow them to interact with different structures within living organisms. Because of these features, numerous nanoparticles are used in medicine as delivery agents for biomolecules. However, off-target drug delivery can cause serious side effects to normal tissues and organs. Considering this issue, it is essential to develop bioengineering strategies to significantly reduce systemic toxicity and improve therapeutic effect. In contrast to passive delivery, nanosystems enable to obtain enhanced therapeutic efficacy, decrease the possibility of drug resistance, and reduce side effects of “conventional” therapy in cancers. The present review provides an overview of the most recent (mostly last 3 years) achievements related to different biomolecules used to enable targeting capabilities of highly diverse nanoparticles. These include monoclonal antibodies, receptor-specific peptides or proteins, deoxyribonucleic acids, ribonucleic acids, [DNA/RNA] aptamers, and small molecules such as folates, and even vitamins or carbohydrates.

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A core–shell structured polyplex for efficient and non-toxic gene delivery

Abstract: We developed a core–shell polyplex with minimal high generation dendrimer to condense DNA and low-molecular-weight linear polyethylenimine coated on the core. The polyplex represented both high transfection efficacy and low toxicity.

Cited by 11 publications

References 47 publications

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy

Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: A concise review

Nanocomposites as biomolecules delivery agents in nanomedicine

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