A correlation between mechanical and electrical properties of the synthetic hydrogel chosen as an experimental model of cytoskeleton

Shklyar, T. F.; Сафронов, А. П.; Klyuzhin, I. S.; Pollack, Gerald H.; Blyakhman, F. A.

doi:10.1134/s0006350908060146

Cited by 23 publications

(25 citation statements)

References 14 publications

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“…Close resemblance of the structural and functional features of gel‐like synthetic and living systems is well known . It is the most important argument for applying synthetic hydrogels for needs of biomedicine.…”

Section: Discussionmentioning

confidence: 99%

“…The electrical potential of the gels was measured using two identical Ag/AgCl tapered microelectrodes typically used in biophysical studies for intracellular voltage measurement. The details of potential measurements of the gels were described in several studies performed by us and other authors . Briefly, thin‐walled, single‐barrel borosilicate capillary tubes (TW150F‐6, World Precision Instruments, USA) were single‐pulled using a standard electrode puller (ME‐3, EMIB Ltd, Russia).…”

Section: Methodsmentioning

confidence: 99%

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Biomimetic gels with chemical and physical interpenetrating networks

Dobreikina

Shklyar

Сафронов

et al. 2018

Polymer International

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This study aimed to create and to characterize the functional properties of gels with semi-interpenetrating network (semi-IPN) with focus on possible use of these composites in biomedical engineering. Polyacrylamide as a synthetic biocompatible polymer was chosen for the chemical network. The physical network comprised the gel-forming polysaccharides xanthan gum or gellan gum. Gels were synthesized by radical polymerization of acrylamide in aqueous solutions of polysaccharides. Mechanical and electrical properties of gels with 0.2, 0.4, 0.6, 0.8 and 1.0 wt% content of polysaccharide were investigated. It was found that the inclusion of a small amount of xanthan or gellan into the polymeric network of a polyacrylamide gel significantly shifts the gel electrical potential towards the rest potential of living cells and Young's modulus towards the elasticity limits of biological soft tissues like non-activated muscles. From the viewpoint of biomedical applications, the main advantage of the proposed composites is that the semi-IPN structure provides a nonlinear dependence of gel tension on gel deformation, which mimics the elasticity of natural tissues. This feature opens the possibility for the promising use of the proposed gels for musculoskeletal minibioimplants or scaffolds for tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Biomimetic gels with chemical and physical interpenetrating networks

Dobreikina

Shklyar

Сафронов

et al. 2018

Polymer International

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“…In earlier work, we investigated synthetic hydrogels as experimental models of the cytoskeleton (Safronov et al, 2006;Shklyar et al, 2008Shklyar et al, , 2010Shklyar et al, , 2011. We demonstrated a negative electrochemical (Donnan) potential with values close to those of the intracellular potential (Safronov et al, 2006).…”

Section: Introductionmentioning

confidence: 79%

“…We demonstrated a negative electrochemical (Donnan) potential with values close to those of the intracellular potential (Safronov et al, 2006). Further, mechanical transformations triggered by the changes in ionic composition of the surrounding solution were accompanied by simultaneous changes of the gel electrochemical potential (Shklyar et al, 2008). For instance, hydrogel shrinking resulted in a decrease of the gel potential's absolute value.…”

Section: Introductionmentioning

confidence: 87%

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Effect of cytoskeletal elastic properties on the mechanoelectrical transduction in excitable cells

Shklyar

Dinislamova

Сафронов

et al. 2012

Journal of Biomechanics

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Electrospun crosslinked poly(acrylic acid) fiber constructs: towards a synthetic model of the cortical layer of nerve

et al. 2014

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In an attempt to mimic properties of the polyanionic nanofibrous cortical layer (ectoplasm) of nerve, tube-shaped poly(acrylic acid) (PAA) nanofiber constructs were prepared via electrospinning. The influence of processing parameters on the morphology of the electrospun PAA nanofibers was systematically investigated. Smooth and uniform PAA nanofibers with average fiber diameter of 820 nm were produced at a concentration of 4 wt% with a flow rate of 0.8 mL h −1 when a high voltage of 15 kV was applied. Water-stable PAA nanofibers were obtained by thermally crosslinking PAA with ethylene glycol. The resulting tubes were neutralized to the sodium polyacrylate form and were shown to undergo reversible and abrupt length changes upon titration with CaCl 2 followed by titration with sodium citrate. The sharpness of the length transition was found to be highly dependent upon the bathing NaCl concentration and the operation temperature. It is suggested that electrospun PAA may be a promising candidate as a key element of an abiotic macromolecular mimic of selected properties of axons.

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A correlation between mechanical and electrical properties of the synthetic hydrogel chosen as an experimental model of cytoskeleton

Cited by 23 publications

References 14 publications

Biomimetic gels with chemical and physical interpenetrating networks

Biomimetic gels with chemical and physical interpenetrating networks

Effect of cytoskeletal elastic properties on the mechanoelectrical transduction in excitable cells

Electrospun crosslinked poly(acrylic acid) fiber constructs: towards a synthetic model of the cortical layer of nerve

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