A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes

Pandeya, K. B.; Tripathi, I. P.; Mishra, Mahendra Kumar; Dwivedi, Neelesh; Pardhi, Yogesh; Kamal, A.T.M. Mostafa; Gupta, Pankaj; Dwivedi, Nupa; Chinmayi, Mishra

doi:10.4236/ijoc.2013.31001

Cited by 29 publications

(17 citation statements)

References 146 publications

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“…Although an increasing number of plants are being scientifically documented for their antihyperglycemic, antioxidant and insulin stimulating activities [51] the lack of scientific data supporting the anti-diabetic properties of fresh Carica papaya is now slowly changing. The antihyperglycemic effect of papaya is thought to target pancreatic β cells by improving their sensitivity to insulin, at the same time inhibiting α-amylase and α-glucosidase [52], a response which bears much resemblance to a second generation sulfonylurea called glibenclamide.…”

Section: Interaction Of Fpp At the Physiological And Organ System Levmentioning

confidence: 99%

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Somanah-Bhugowandeen¹,

Putteeraj²,

Aruoma³

et al. 2018

Preprint

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The simplistic morphological characteristics of the Carica papaya, papaya or ‘pawpaw’ should not be the cause for underestimating its potential as a nutraceutical. The market for papaya has been expanding at a staggering rate, partly due to its applicability as a biofortified product, but mostly for its phytochemical properties and traditional health benefits. Recent characterization studies have showed that the entirety of papaya or using a formulation of fermented papaya promotion (FPP) displays effective free radical scavenging abilities, thought to be influenced by its phenolic, carotenoids, flavonoid or amino acid profile. Aiming at reducing the impact of free radical-induced oxidative damage in the human system, the antioxidant properties of FPP have been found to potently target a broad spectrum of diseases ranging from neurological impairments such as senile dementia to systemic diseases, to its interference at the cellular level and support of normal biological ageing processes. FPP has thus been extensively investigated for its ability to exert cellular protective effects and reduce oxidative stress via mitigation of genetic damage, lipid peroxidation and enzymatic inactivation in diseases. Oxidative stress reduction strategies using FPP and its holistic approach in disease prevention and management, with a focus on diabetes, cancer and cognitive health, contributes unequivocally to wellness in an aging population.

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Section: Interaction Of Fpp At the Physiological And Organ System Levmentioning

confidence: 99%

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Somanah-Bhugowandeen¹,

Putteeraj²,

Aruoma³

et al. 2018

Preprint

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“…Diabetes mellitus (DM) is a metabolic disorders characterized by deregulation in carbohydrate metabolism and high blood sugar levels over a prolonged period resulting from either destruction or impairment of insulin-secreting pancreatic β cells and target tissue. 1,2 DM is a group of a metabolic disease of all age groups especially the middle age people. 3 The long term diabetes leads to complications in various body systems such as diabetic kidney.…”

Section: Introductionmentioning

confidence: 99%

“…These types of extracts can reduce the blood glucose level by inhibiting the gastric enzymes which are obligatory for the break the polysaccharides into the simple sugar. 1 The bioactive compounds contained in red betel leaves and Dayak onions have the potential to be used as antidiabetic drugs. The red betel leaf extract at a dose of 50 mg/kg body weight and a dose of 100 mg/kg body weight could reduce blood glucose levels in alloxan-induced rats and administered onion extract of water and ethanol with a dose of 100 mg/ kg for 28 days.…”

Section: Introductionmentioning

confidence: 99%

The Effect Hypoglycemic of Ethanol Extract Combination Red Betel Leaf (Piper crocatum) and Dayak Onion (Eleutherine palmifolia Merr) in Streptozotocin-Induced

Anggi¹,

Magfirah²

2019

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Background: Red betel leaf and Dayak onion is used traditionally to treat diabetes mellitus, The use of this combination of extracts to assess the effectiveness of the combination therapy is getting better by working synergistically. Objective: This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of red betel leaf and Dayak onion of male rats (Rattus norvegicus). Methods: The number of 35 male rats were divided into 7 groups and each group consisted of five rats. The first group (normal control) was given Na CMC; the second group (negative control) streptozotocin-induced ; the third group (positive control) glibenclamide , while the 4 th , 5 th ,6 th , and 7 th were successively given a single dose of ethanol extract of red betel leaf 25 mg/KgBB, a single dose of Dayak onion50 mg/ KgBB, combination red betel leaf and forest onion bulbs, 25+50 and 50+100 mg/kg bb. Each rat group was intraperitoneally (IP) induced with STZ 40 mg/KgBB and then treated for 21 days. The hypoglycemic effect was tested by using the God-Pap method. Result: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of red betel leaf and forest onion bulbs. The study concluded that the combination of red betel leaf and Dayak onion at doses 25 mg/KgBB and 50 mg/KgBB were synergistic in reducing glucose. Conclusion: In conclusion, the ethanol extract combination of red betel leaf and dayak onion have hypoglycemic effects.

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“…Flavonoids have the ability to reduce the formation of free radicals and to scavenge free radicals (Rice- Evans et al, 1996;Amić et al, 2003;Ganesan et al, 2016). Consequently, the exploration for phyto-nutraceutical substances with antioxidative activity has been exaggerated in recent years (Lobo et al, 2010;Pandeya et al, 2013) mainly in connection with type 2 diabetes (Jakus, 2000;Montonen et al, 2004;Kamalakkannan and Prince, 2006;Pandey and Rizvi, 2009;Dewanjee et al, 2011;Wedick et al, 2012;Babu et al, 2013;Kan et al, 2015;Li et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Type 2 Anti-Diabetes on Bound Flavonoids of Barringtonia racemosa (L.) Spreng. Kernel in Glucose-Induced Diabetic Rats

Musman

Audina

Rahmayani

et al. 2017

American Journal of Pharmacology and Toxicology

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A study of type 2 anti-diabetes on bound flavonoids fraction from the kernel of Barringtonia racemosa (L.) Spreng. in glucose-induced diabetic rats was performed. This learning aimed to gather scientific information about the possibility to utilize kernel of B. racemosa as a raw material of antidiabetic drug. The antioxidant property of the bound flavonoids was determined by the DPPH scavenging method compared to the ascorbic acid. Assessment of type 2 anti-diabetes was conducted on glucose-induced diabetic Rattus norvegicus Wistar strain compared to metformin and the data were analyzed through one-way ANOVA software. Histopathological studies of the pancreas and kidney were made to get evidence of the β-cell performance and the renal tissue respectively. The DPPH testing at the wavelength of 517 nm showed the bound flavonoids and the ascorbic acid showed absorbance at 0.097 and 0.080 correlated with IC 50 values of 7.51 and 6.50 ppm respectively. The results of one-way ANOVA indicated that the administration of bound flavonoids was significant (F(2,11) = 8.60, p = 0.008) to reduce blood glucose level in the tested rats. The diabetic rats treated with the extract experienced an antidiabetic effect equivalent to an antidiabetic effect of metformin. Histopathologic observations showed increasing of the granulated β-cell (F(3, 15) = 26.09, p<0.0001) and no renal tissue damage (F(3, 15) = 0.23, p = 0.873) in the tested rats. The conclusion raised from the data of this study revealed that the bound flavonoids from the kernel of B. racemosa (L.) Spreng. could be utilized as a drug source of type 2 anti-diabetes.

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A Critical Review on Traditional Herbal Drugs: An Emerging Alternative Drug for Diabetes

Cited by 29 publications

References 146 publications

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

Discovering the health promoting potential of fermented papaya preparation- its future perspectives for the dietary management of oxidative stress during diabetes

The Effect Hypoglycemic of Ethanol Extract Combination Red Betel Leaf (Piper crocatum) and Dayak Onion (Eleutherine palmifolia Merr) in Streptozotocin-Induced

Assessment of Type 2 Anti-Diabetes on Bound Flavonoids of Barringtonia racemosa (L.) Spreng. Kernel in Glucose-Induced Diabetic Rats

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