A curcumin activated carboxymethyl cellulose–montmorillonite clay nanocomposite having enhanced curcumin release in aqueous media

Madusanka, Nadeesh; Silva, K.M. Nalin de; Amaratunga, G.A.J.

doi:10.1016/j.carbpol.2015.08.030

Cited by 66 publications

(39 citation statements)

References 26 publications

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“…For example, solid lipid nanoparticles 24 and chitosan-montmorillonite clay NPs were reported as sustained delivery carriers for curcumin, but showed drug release throughout the GIT. 25,26 As already reported, NPs are taken up through macrophages in the active inamed area of UC, and adherence of small particles on the thicker mucus layer (high mucus production in active UC) in the inamed region is also high. The smaller size of NPs makes them capable of accumulating in the inamed area.…”

Section: 9mentioning

confidence: 68%

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Raj

Kaul

et al. 2018

RSC Adv.

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aIn the present investigation we have prepared and characterized curcumin (CN)-containing chitosan nanoparticles (CS-NPs) coated with Eudragit FS 30D for colon-specific drug delivery for treatment of ulcerative colitis. Methods: CS-NPs were prepared by ionic gelation using tripolyphosphate. To specify pH sensitive delivery, CS-CN-NPs were coated with Eudragit FS 30D by using a solvent evaporation method. Different process parameters were evaluated, and the optimized formulation was characterized by particle size, size distribution, zeta potential and encapsulation efficiency before lyophilization. The lyophilized product was further subjected to Fourier-transform infrared spectroscopy, and particle morphology and in vitro drug release in different media were studied. Results: the kinetics of in vitro drug release from the CS-CN-NPs revealed sustained release behaviour of the developed carriers. In vivo biodistribution study by gamma-scintigraphy showed good accumulation of the developed nanocarriers in the colonic region. Conclusion: sustained and pH stimulated delivery of CN to the colon was successfully attained via coating of CS-NPs with Eudragit FS 30D to circumvent poor absorption and availability of CN.

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Section: 9mentioning

confidence: 68%

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Raj

Kaul

et al. 2018

RSC Adv.

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“…Initially, the high and fast release of ofloxacin was recorded and effectively inhibited the growth of E. coli bacteria . Carboxymethyl cellulose was used as an emulsifier for curcumin and the formulation of curcumin activated carboxymethylcellulose montmorillonite nanocomposite is suitable as a curcumin carrier having an enhanced release and structural properties …”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Amalraj¹,

Gopi²,

Thomas

et al. 2018

Macromolecular Symposia

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Nanotechnology with bionanomaterials have tremendous potential to enhance and utilize for nutrient and bioactive absorption, drug delivery systems, pharmaceutical, and nutraceutical field through various applications. Cellulose nanomaterials are green materials that are obtained from renewable sources and possess exceptional mechanical strength and biocompatibility. The associated unique physical and chemical properties have made various nanocomposite materials an intriguing prospect for different application in the biomedical, food, and nutraceutical industries. In this review, we have discussed and provided a summary of the recent researches in the utilization of cellulosic nanomaterials in applications related to food packaging, bone tissue engineering, wound dressing, drug delivery, and nutraceutical research area and industries.

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“…1). Such an increase in d-value could be attributed to the migration of CPX molecules into the interlayer space of the clay mineral in the composite through forming H-bonds (Madusanka et al, 2015).…”

Section: Isotherm Experimentsmentioning

confidence: 99%

Municipal solid waste biochar-bentonite composite for the removal of antibiotic ciprofloxacin from aqueous media

Ashiq

Adassooriya

Sarkar

et al. 2019

Journal of Environmental Management

114

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A curcumin activated carboxymethyl cellulose–montmorillonite clay nanocomposite having enhanced curcumin release in aqueous media

Cited by 66 publications

References 26 publications

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

Cellulose Nanomaterials in Biomedical, Food, and Nutraceutical Applications: A Review

Municipal solid waste biochar-bentonite composite for the removal of antibiotic ciprofloxacin from aqueous media

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