2016
DOI: 10.2967/jnumed.115.169383
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A Cystine Knot Peptide Targeting Integrin αvβ6 for Photoacoustic and Fluorescence Imaging of Tumors in Living Subjects

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Cited by 22 publications
(22 citation statements)
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“…Integrin avb6 has been shown to be a promising target for identification of PDAC, and differentiation with pancreatitis and normal pancreatic tissue, with retained expression in vital tumor cells after neoadjuvant therapy (12)(13)(14)(15)30). Nowadays, the majority of patients will receive neoadjuvant therapy prior to surgery due to late onset of symptoms and therefore, presentation with locally advanced disease, or borderline resectable tumors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Integrin avb6 has been shown to be a promising target for identification of PDAC, and differentiation with pancreatitis and normal pancreatic tissue, with retained expression in vital tumor cells after neoadjuvant therapy (12)(13)(14)(15)30). Nowadays, the majority of patients will receive neoadjuvant therapy prior to surgery due to late onset of symptoms and therefore, presentation with locally advanced disease, or borderline resectable tumors.…”
Section: Discussionmentioning
confidence: 99%
“…At this point, this peptide is tested in a phase I trial in humans as a targeted PET tracer, [18F]FP-R01-MG-F2, without any safety concerns (eIND #126379). Zhang and colleagues recently published data showing the development and preclinical validation of R01 conjugated to the photoacoustic dye Atto-740 (15). Zhang showed selective binding of the imaging agent to avb6-positive tumors.…”
Section: Introductionmentioning
confidence: 99%
“…In our previous study 10 , the probe A740-R 0 1, a peptide labeled with the fluorescent dye Atto 740, was able to detect α v β 6 -positive tumors in living subjects, but the signals were relatively weak. Moreover, Atto 740 is still not approved for human use.…”
mentioning
confidence: 93%
“…Zhang et al engineered a cystineknot peptide, R 0 1, labeled with Atto740 dye and evaluated it using a v b 6positive (A431) and a v b 6 -negative (293T) tumors in mice (28). Significant photoacoustic signal enhancement was found in A431 tumors over 4 h after injection (Figs.…”
Section: Molecular Targeting Approach For Paimentioning
confidence: 99%