The San Andrés landslide on El Hierro (Canary Islands) represents a rare opportunity to study an incipient volcanic island flank collapse with an extensive onshore part. The presented research improves the knowledge of the internal structure and rock characteristics of a mega-landslide before its complete failure. The investigation combines multiple geophysical measurement techniques (active and passive seismic) and remotely sensed, high spatial resolution surveys (unmanned aerial vehicle) with in situ and laboratory geotechnical descriptions to characterize the rock properties inside and outside the San Andrés landslide. The available geophysical and geological data have been integrated into 3D geomodels to enhance their visual interpretation. The onshore geophysical investigations helped detect the possible San Andrés landslide sliding surfaces at depths between 320 m and 420 m, with a rather planar geometry. They also revealed that rocks inside and outside of the landslide had similar properties, which suggests that the previous fast movements of the landslide did not affect the bulk properties of the displaced rocks as the failure chiefly occurred along the weakened sliding plane. Uniaxial strength tests on basalt rocks further indicate a high variability and spatial heterogeneity of the rock strength properties due to the different types of volcanic rocks and their texture. The new information on the rock properties and structural setting of the San Andrés landslide can now be used to develop realistic geotechnical slope models of the onshore part of the flank collapse that are possibly applicable for slope stability or deformation calculations. It will also help assess related hazards marked by a low occurrence probability and a high impact potential.