A Diffusion Tensor Magnetic Resonance Imaging Study of Corpus Callosum From Adult Patients With Migraine Complicated With Depressive/Anxious Disorder

Abstract

There might be an integrity change of neurofibrotic microstructures existing as a possible neuroanatomical basis in the CC of migraine patients complicated with depressive/anxious disorder.

Principal Component Analysis of Diffusion Tensor Images to Determine White Matter Injury Patterns Underlying Postconcussive Headache

“…26 However, most interesting, abnormalities of this region are also seen in other forms of chronic headache, such as migraine. 27,28 In fact, in nontraumatic migraine, abnormalities of the splenium are associated with a more chronic disease course, greater headache frequency, and comorbid neuropsychiatric conditions. 15 Lower values of PC 4 also corresponded to increased FA in the genu of the corpus callosum.…”

Statistical Shape Analysis of the Corpus Callosum and the Cerebellum in Migraine Patients

“…A recent study by Li et al suggested that fractional anisotropy values of the corpus callosum (genu, body, and splenium) in migraine patients with depressive/anxious disorders were significantly lower compared to the values of the control group and the migraine group without depressive/anxious disorders. 10 In the same study, the authors reported that there might be an integrity change or damage of neurofibrotic microstructure existing in the CC of migraine patients with depressive/anxious disorder. 10 Furthermore, Agarwal et al described a patient suffering from migraine with aura associated with a transient abnormality in the midline of the splenium of the corpus callosum, showed by magnetic resonance imaging.…”

“…10 In the same study, the authors reported that there might be an integrity change or damage of neurofibrotic microstructure existing in the CC of migraine patients with depressive/anxious disorder. 10 Furthermore, Agarwal et al described a patient suffering from migraine with aura associated with a transient abnormality in the midline of the splenium of the corpus callosum, showed by magnetic resonance imaging. 37 Our study showed that CC shape in migraine patients was significantly different from that of the controls.…”

“…Involvement of CC in migraineurs has been shown in a few studies, especially as case reports. 5,10 Sub-clinic periventricular and deep white matter, and callosal lesions were reported to be found in the cranial magnetic resonance (MR) images of migraineurs. 2 In addition to the involvement of CC, cerebellar dysfunction in migraine, especially associated with specific forms of migraine has been recognized for for many years.…”

Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging: preliminary findings

“…Therefore, it remains unclear whether non-specific iron deposition plays a causative role in the development of migraine or is a consequence of repetitive attacks. DTI studies have reported both positive and negative results in terms of alterations of white matter structures in migraineurs [10,[15][16][17]22], which suggests that DTI changes are unlikely to characterize migraine. Therefore, our results of selective alterations in DKI metrics of the PAG represent a specific and pathognomonic imaging finding to evaluate patients with migraine.…”