A direct optical immunosensor for atrazine detection

Brecht, Andreas; Piehler, Jacob; Lang, G.; Gauglitz, Günter

doi:10.1016/0003-2670(95)00120-o

Cited by 110 publications

(41 citation statements)

References 18 publications

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“…pattern. [12] Adsorption or bonding processes on thin cyclopeptide layers can thus be registered directly, and a large amount of analytes and receptors can be examined in a short period of time.…”

Section: Methodsmentioning

confidence: 99%

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Investigation of the Molecular Recognition of Amino Acids by Cyclopeptides with Reflectometric Interference Spectroscopy

Leipert

Nopper

Bauser

et al. 1998

Angewandte Chemie Intl Edit

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Section: Methodsmentioning

confidence: 99%

“…To exhibit the potential of this method, a model library of isoxazolidines [12] on Rink amide A RAM resin was synthesized by the split-and-combine method [13] (Scheme 1). The polymer-bound library obtained consists of a total of 18 compounds.…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Molecular Recognition of Amino Acids by Cyclopeptides with Reflectometric Interference Spectroscopy

Leipert

Nopper

Bauser

et al. 1998

Angewandte Chemie Intl Edit

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“…In a direct assay, the antigens are incubated with excess amounts of immobilized antibodies [30,31]. The antigen could be a fluorescent compound in fluorescence-based measurement [30].…”

Section: Antigens/antibodiesmentioning

confidence: 99%

Miniature fiber-optic multicavity Fabry–Perot interferometric biosensor

et al. 2005

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(ABSTRACT)Fiber-optic Fabry-Perot interferometric (FFPI) sensors have been widely used due to their high sensitivity, ease of fabrication, miniature size, and capability for multiplexing. However, direct measurement of self-assembled thin films, receptor immobilization process or biological reaction is limited in the FFPI technique due to the difficulty of forming Fabry-Perot cavities by the thin film itself. Novel methods are needed to provide an accurate and reliable measurement for monitoring the thin-film growth in the nanometer range and under various conditions. In this work, two types of fiber-optic multicavity Fabry-Perot interferometric (MFPI) sensors with built-in temperature compensation were designed and fabricated for thin-film measurement, with applications in chemical and biological sensing. Both the tubing-based MFPI sensor and microgap MFPI sensor provide simple, yet high performance solutions for thin-film sensing. The temperature dependence of the sensing cavity is compensated by extracting the temperature information from a second multiplexed cavity. This provides the opportunity to examine the thin-film characteristics under different environment temperatures.To demonstrate the potential of this structure for practical applications, immunosensors were fabricated and tested using these structures. Self-assembled polyelectrolytes served as a precursor film for immobilization of antibodies to ensure they retain their biological activity. This not only provides a convenient method for protein immobilization but also presents the possibility of increasing the binding capacity

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“…This method has detection limits of 1-5 pg/mm 2 at present. Some applications in biochemical research (quantitative detection of high and low (competitive assay) molecular weight analytes, kinetic measurements for interaction analysis, thermodynamic analysis of titration curves) and pesticide analysis have been published [83,84,273,274,358].…”

Section: Directmentioning

confidence: 99%