IR spectroscopic mapping of resin beads allows destruction-free characterization of polymer-bound combinatorial compound libraries. By choice of different absorptions for IR reconstruction, resin beads with common structural elements can be "fished out" of a library and statistically investigated.

Microstructuring of surfaces: Electrochemical polymerization after removal of a photolabile protecting group (nitrobenzyl group) represents a new method for spatially resolved immobilization of ligands or receptors. Thus, the electropolymerization of 3-hydroxyphenylacetyl peptides such as 1 on electrodes can be controlled by light.

An approach to the immobilization of compounds on surfaces that should also be applicable to combinatorial libraries is described. The attachment of an electrochemically polymerizable phenol group to molecules, in this case biotin, followed by anodic polymerization is shown to yield thin insulating layers. When the polymerization takes place in several mini‐cells simultaneously, the parallel immobilization of substances can be achieved. The characterization of layers of three anodically polymerized biotinylated phenols is also described in detail.

Bei der Suche nach selektiven Rezeptoren besteht ein vielversprechender Ansatz in der Immobilisierung von Cyclopeptiden auf Sensoroberflächen (siehe Bild) und anschließender Detektion niedermolekularer Analyte durch die reflektometrische Interferenzspektroskopie (RIfS). Diese innovative Methode bietet in Verbindung mit der kombinatorischen Chemie ein großes Potential für Anwendungen in der Sensorik.

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