A diselenium-bridged covalent organic framework with pH/GSH/photo-triple-responsiveness for highly controlled drug release toward joint chemo/photothermal/chemodynamic cancer therapy

Lou, Han; Chu, Lichao; Zhou, Wuyi; Dou, Jinli; Teng, Xiaotong; Tan, Wei; Zhou, Baolong

doi:10.1039/d2tb01015a

Cited by 32 publications

(22 citation statements)

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“…Due to the pH sensitivity and high affinity of DMTP-TAPB with DOX molecules [ 19 ], COF HPs were investigated for DOX delivery. To load DOX, the nanocarriers were incubated with DOX stock solution at room temperature for 24 h. As summarized in Table 1 , the COF HP had a DOX loading of 46.8%, which was significantly higher than DMSN (15.2%), DMSN@COF (29.1%), and bulk COF (32.1%), and also the highest loading for DOX among the COFs available in the literature [ 16 , 17 , 18 , 19 , 21 ]. The extraordinary loading capacity of COF HPs were mainly attributed to the higher surface area and porosity of the materials ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…As for drug delivery applications, it is important to design materials with biocompatible, biodegradable, and stimuli-responsive release properties as well as high loading capacities. To achieve stimuli-responsive release properties, the researchers developed a class of COF materials connected via acid degradable covalent bonds, which makes them promising as intracellular drug delivery vehicles [ 13 , 14 , 15 , 16 , 17 , 18 ]. For instance, Liu et al [ 19 ] reported the 1,3,5-tris(4-aminophenyl)benzene (TAPB) and 2,5-dimethoxyterephthaldehyde (DMTP) connected COF (TAPB-DMTP COF) with cleavable C=N bonds under an acidic environment, which allows for the deconstruction of COF materials inside the subcellular compartments (e.g., endosomes, lysosomes) of tumor cells with an acidic condition of ca.…”

Section: Introductionmentioning

confidence: 99%

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Templated Assembly of pH-Labile Covalent Organic Framework Hierarchical Particles for Intracellular Drug Delivery

et al. 2022

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Covalent organic frameworks (COF), a class of emerging microporous polymers, have been restrained for drug delivery applications due to their limited controllability over particle sizes and degradability. Herein, a dendritic mesoporous silica nanosphere (DMSN)-mediated growth strategy is proposed to fabricate hierarchical DMSN@COF hybrids through in situ growing of 1,3,5-tris(4-aminophenyl)benzene and 2,5-dimethoxyterephthaldehyde connected COF with acid cleavable C=N bonds. After the removal of the DMSN template, COF hierarchical particles (COF HP) with tailored particle sizes and degradability were obtained. Notably, the COF HP could be degraded by 55% after 24 h of incubation at pH 5.5, whereas the counterpart bulk COF only showed 15% of degradation in the same conditions. Due to the improved porosity and surface area, the COF HP can be utilized to load the chemotherapeutic drug, doxorubicin (DOX), with a high loading (46.8 wt%), outperforming the bulk COF (32.1 wt%). Moreover, around 90% of the loaded DOX can be discharged from the COF HP within 8 h of incubation at pH 5.5, whereas, only ~55% of the loaded DOX was released from the bulk COF. Cell experiments demonstrated that the IC50 value of the DOX loaded in COF HP was 2–3 times lower than that of the DOX loaded in the bulk COF and the hybrid DMSN@COF. Attributed to the high loading capacity and more pH-labile particle deconstruction properties, COF HP shows great potential in the application as vehicles for drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Templated Assembly of pH-Labile Covalent Organic Framework Hierarchical Particles for Intracellular Drug Delivery

et al. 2022

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“…Compared to the typical porous nanomaterials (e.g., silica), the synthesis of MOFs is simpler and more efficient ( Wu et al, 2014 ). Moreover, MOFs can carry metal nanoparticles in for delivering organic materials and drugs with therapeutic purposes ( Dhakshinamoorthy and Garcia, 2012 ), act as a pH/GSH/photo-triple-responsive carrier in developing multimodal chemo/photothermal/chemodynamic therapy ( Lou et al, 2022a ), serve as an artificial enzyme to create a pH sensitive ( Mandal et al, 2022 ) ( Lou et al, 2022b ) ( Xu et al, 2022 ) DDS and as a photoactive dual-cationic covalent MOF to construct a cation/photothermal/NO antibacterial therapy system ( Luo et al, 2022a ) ( Luo et al, 2022b ). Ferey and coworkers first studied the ability of MIL-100(Fe) and MIL-101(Cr) to encapsulate ibuprofen molecules for sustained drug delivery ( Horcajada et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite

Gharehdaghi

Naghib

Rahimi

et al. 2023

Front. Mol. Biosci.

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Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier.

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“…[6][7][8][9][10] Porphyrin, a common building block of photothermal material, has been extensively studied as an efficient and durable photosensitizer (PS) for antimicrobial therapy. [11] Whereas, the high cost and complex synthesis process limit its applicability. [12] Hence, novel strategies are needed to reduce the cost and finely maintain the antibacterial activity of porphyrin-based agents.…”

Section: Introductionmentioning

confidence: 99%

Core‐Shell Structured hybrid with Photo‐triggered Antibacterial activity for Enhancing Skin Regeneration

Zhang

Gao

et al. 2023

ChemistrySelect

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Open wounds infected by bacteria are gearing increasing attention whose treatment are complicated by the appearance of multidrug-resistant bacteria. Photothermal therapy, kill bacteria through the photothermal conversion, has been extensively studied. Whereas, the high cost and low yield of the active ingredients have limited its widespread use. To address this challenge, the template assisted coating strategy was adopted to prepare a biocompatible photothermal agent, where the hybrid was prepared via in situ copolymerization of 5,10,15,20-tetrakis(4-ethynylphenyl)-21H,23H-porphine (Por) on the surface of ZIF-8 template. The introduction of ZIF-8 in the inner of the hybrid, could not only lower the cost of photosensitizer (i. e., the porphyrin), but also maintain the activity of photosensitizer (PS) finely, which could be used directly as the antimicrobial dressing. In vitro experiments validated the asprepared hybrid presents high-efficiency PTT antibacterial activity. Meanwhile, in vivo chronic wound-healing experiments on mice verified the as-synthesized hybrid also delivers excellent anti-infection and tissue remodeling activities. This work highlights the potential of low-cost hybrid-based multifunctional biomaterials in the treatment of skin injuries in clinical settings.

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A diselenium-bridged covalent organic framework with pH/GSH/photo-triple-responsiveness for highly controlled drug release toward joint chemo/photothermal/chemodynamic cancer therapy

Abstract: Here, a novel joint chemo/photothermal/chemodynamic therapy was developed using a pH/GSH/photo triple-responsive 2D-covalent organic framework (COFs) drug carriers for passive target treatment of tumor with extraordinarily high efficiency. The well-designed...

Cited by 32 publications

References 59 publications

Templated Assembly of pH-Labile Covalent Organic Framework Hierarchical Particles for Intracellular Drug Delivery

Templated Assembly of pH-Labile Covalent Organic Framework Hierarchical Particles for Intracellular Drug Delivery

Highly improved pH-Responsive anticancer drug delivery and T2-Weighted MRI imaging by magnetic MOF CuBTC-based nano/microcomposite

Core‐Shell Structured hybrid with Photo‐triggered Antibacterial activity for Enhancing Skin Regeneration

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