A Double Blind Pilot Study of Dicynene in the Control of Menorrhagia

Abstract

In a pilot study in general practice, using a double blind cross-over technique, twenty-six patients with menorrhagia were treated with Dicynene (ethamsylate) or a placebo preparation during four menstrual periods, each preparation being given for two consecutive periods.The number of tampons used and number of days of menstrual loss were recorded together with the patient's assessment of the severity of bleeding.On statistical analysis the results demonstrated the superiority of Dicynene over placebo in reducing the amount and duration of bleeding in menorrhagia.Twenty-five patients reported an absence of side-effects during the trial. Slight indigestion was recorded in one patient during Dicynene treatment.

Treatment of menorrhagia during menstruation: randomised controlled trial of ethamsylate, mefenamic acid, and tranexamic acid

“…A previous study of ethamsylate recorded a significant reduction in the number of tampons and duration of bleeding21 but we found no effect of ethamsylate on these variables.…”

Effectiveness of Etamsylate in Intrauterine-Device Menorrhagia

“…Since these actions might be expected to reduce the amount and duration of menstrual bleeding (1) and to be useful in the treatment of acyclic uterine bleeding (2), it seemed reasonable to investigate whether the administration of etamsylate to IUD users would reduce menstrual blood loss and the incidence of haemorrhagic side-effects. 1 Dicynone®, OM Laboratories, Geneva (Switzerland). Tablets containing 250 mg etamsylate.…”

Therapeutic Efficacy and Mechanism of Action of Ethamsylate, a Long-Standing Hemostatic Agent

“…[14][15][16][17] Of these, Harrisson and Campbell 15 found that ethamsylate reduced mean menstrual blood loss more in patients with primary menorrhagia ( -50%) than in women using intrauterine devices ( -19%; ethamsylate was given in 2 Â 250-mg tablets, 4 times daily, starting 5 days before the anticipated onset of menstruation and continuing for 10 days). Interestingly, the difference between the 2 groups was explained by the differing values of initial blood loss, which was significantly higher in the group with primarymenorrhagia.…”