A double‐blind trial of 1% ketoconazole shampoo versus placebo in the treatment of dandruff

Go, Ionescu; Wientjens, D. P. W. M.; Koster, M.

doi:10.1111/j.1439-0507.1992.tb00828.x

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…Therapies considered to be effective include PTZ (11,13,(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61), selenium sulfide (47)(48)(49)(50)54,58,63,64,82), salicylic acid (4,5,47), sulfur (4,5,47), coal tar (4,5,48), hydrocortisone (41), and ketoconazole (13,51,52,57,61,(63)(64)(65)(66)(67)(68)(69)(70)(71)(72)(73)…”

Section: Therapies and Efficacymentioning

confidence: 99%

Dandruff and seborrheic dermatitis

Schwartz¹,

Cardin²,

DeAngelis³

et al. 2010

Textbook of Cosmetic Dermatology

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Section: Therapies and Efficacymentioning

confidence: 99%

Dandruff and seborrheic dermatitis

Schwartz¹,

Cardin²,

DeAngelis³

et al. 2010

Textbook of Cosmetic Dermatology

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“…Comprehensive scalp microbiome comparisons have also been performed between cohorts of healthy individuals and dandruff/seborrhoeic dermatitis patients . However, these studies do not take into account individual susceptibility and may be subject to a significant placebo effect bias given that anti‐dandruff efficacy is still reported in 23–55% of the placebo treated subjects . Hence, it is also useful to study the in vitro efficacy of the antifungal agents and other shampoo formulation components on the growth of Malassezia and Staphylococcus prior to accessing their performance in clinical trial.…”

Section: Introductionmentioning

confidence: 99%

In vitro efficacy of antifungal agents alone and in shampoo formulation against dandruff‐associated Malassezia spp. and Staphylococcus spp.

Leong

Schmid

Buttafuoco

et al. 2019

Intern J of Cosmetic Sci

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Objective Dandruff is a complex skin condition characterized by unpleasant itching and flaking of the scalp. It is primarily attributed to the over colonization of Malassezia yeasts such as Malassezia globosa and Malassezia restricta. Some studies also suggest the involvement of staphylococci bacteria in dandruff disease pathogenesis. We aimed to access the effectiveness of anti‐dandruff treatments by determining the efficacy of the active antifungal agents alone or in commercial shampoo formulations against Malassezia and Staphylococcus. Methods The minimum inhibitory concentrations of three anti‐dandruff shampoo antifungals (zinc pyrithione, ketoconazole and ciclopirox) and the witch hazel extract, hamamelitannin were tested against commensal Malassezia and Staphylococcus species using broth microdilution methods. In experiments simulating shampoo exposure and washing conditions on the scalp, we also tested the ability of the above agents in shampoo formulation (Head and Shoulders® (H&S), Ketomed®, Sebiprox®, Erol Healthcare Hair Shampoo® respectively) along with a generic over‐the‐shelf shampoo to inhibit microbial growth. Results Ketomed® and H&S shampoo were the most effective treatments against Malassezia in in vitro assays and washing simulation experiments. Erol Healthcare Hair Shampoo® was less effective against Malassezia as it required a longer contact time to achieve growth inhibition for some species. Sebiprox® showed variable efficacy in washing and contact time experiments whereas the generic over‐the‐shelf shampoo was the least effective in inhibiting Malassezia and Staphylococcus growth. Conclusion From these findings, it is reasonable that patients with dandruff may benefit from applying specific antifungal shampoo although results may vary with microbial species, time of contact and shampoo formulation components.

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“…A total of 31 studies assessed complete clearance of symptoms, which was our prespecified first primary outcome: Abeck 2004 ; Altmeyer 2004 ; Aly 2003 ; Berger 1990 ; Chosidow 2003 ; Dreno 2003 ; Dupuy 2001 ; Elewski 2007 ; Faergermann 1986 ; Go 1992 ; Green 1987 ; Herrera-Arellano 2004 ; Hersle 1996 ; Katsambas 1989 ; Lebwohl 2004 ; Lopez-Padilla 1996 ; Ortonne 1992 ; Pari 1998 ; Piepponen 1992 ; Pierard 1991 ; Pierard-Franchimont 2001 ; Piérard-Franchimont 2002 ; Schofer 1988 ; Shuttleworth 1998 ; Skinner 1985 ; Stratigos 1988 ; Unholzer 2002(I) ; Unholzer 2002(II) ; Van't Veen 1998 ; Vardy 2000 ; Zienicke 1993 .…”

Section: Resultsunclassified

“…One trial ( Herrera-Arellano 2004 ) compared ketoconazole shampoo versus Solanum chrysotricum shampoo. Although 8% (4/51) of those taking ketoconazole failed to achieve complete resolution compared with 13% (7/52) taking Solanum chrysotricum , the difference was not statistically significant (RR 0.58, 95% CI 0.18 to 1.87) (Analysis 7.1).…”

Section: Resultsmentioning

confidence: 99%

Topical antifungals for seborrhoeic dermatitis

Okokon

Verbeek

Ruotsalainen

et al. 2015

Cochrane Database of Systematic Reviews

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Background Seborrhoeic dermatitis is a chronic inflammatory skin condition that is distributed worldwide. It commonly affects the scalp, face and flexures of the body. Treatment options include antifungal drugs, steroids, calcineurin inhibitors, keratolytic agents and phototherapy. Objectives To assess the effects of antifungal agents for seborrhoeic dermatitis of the face and scalp in adolescents and adults. A secondary objective is to assess whether the same interventions are effective in the management of seborrhoeic dermatitis in patients with HIV/AIDS. Search methods We searched the following databases up to December 2014: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2014, Issue 11), MEDLINE (from 1946), EMBASE (from 1974) and Latin American Caribbean Health Sciences Literature (LILACS) (from 1982). We also searched trials registries and checked the bibliographies of published studies for further trials. Selection criteria Randomised controlled trials of topical antifungals used for treatment of seborrhoeic dermatitis in adolescents and adults, with primary outcome measures of complete clearance of symptoms and improved quality of life. Data collection and analysis Review author pairs independently assessed eligibility for inclusion, extracted study data and assessed risk of bias of included studies. We performed fixed-effect meta-analysis for studies with low statistical heterogeneity and used a random-effects model when heterogeneity was high. Main results We included 51 studies with 9052 participants. Of these, 45 trials assessed treatment outcomes at five weeks or less after commencement of treatment, and six trials assessed outcomes over a longer time frame. We believe that 24 trials had some form of conflict of interest, such as funding by pharmaceutical companies. Among the included studies were 12 ketoconazole trials (N = 3253), 11 ciclopirox trials (N = 3029), two lithium trials (N = 141), two bifonazole trials (N = 136) and one clotrimazole trial (N = 126) that compared the effectiveness of these treatments versus placebo or vehicle. Nine ketoconazole trials (N = 632) and one miconazole trial (N = 47) compared these treatments versus steroids. Fourteen studies (N = 1541) compared one antifungal versus another or compared different doses or schedules of administration of the same agent versus one another. Ketoconazole Topical ketoconazole 2% treatment showed a 31% lower risk of failed clearance of rashes compared with placebo (risk ratio (RR) 0.69, 95% confidence interval (CI) 0.59 to 0.81, eight studies, low-quality evidence) at four weeks of follow-up, but the effect on side effects was uncertain because evidence was of very low quality (RR 0.97, 95% CI 0.58 to 1.64, six studies); heterogeneity between studies was substantial ...

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A double‐blind trial of 1% ketoconazole shampoo versus placebo in the treatment of dandruff

Cited by 14 publications

References 6 publications

Dandruff and seborrheic dermatitis

Dandruff and seborrheic dermatitis

In vitro efficacy of antifungal agents alone and in shampoo formulation against dandruff‐associated Malassezia spp. and Staphylococcus spp.

Topical antifungals for seborrhoeic dermatitis

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