1997
DOI: 10.1097/00007632-199707010-00012
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A Familial Predisposition Toward Lumbar Disc Injury

Abstract: There is a familial predisposition toward lumbar disc pain and injury. This information may be helpful in occupational counseling or for targeting specific populations with preventative, interventional strategies.

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Cited by 43 publications
(25 citation statements)
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“…Other relevant studies have supported the idea that degenerative disc disorders may be genetically determined [9][10][11][12] . The first gene mutations associated with intervertebral disc degeneration in humans were reported in 1998 13) .…”
mentioning
confidence: 86%
“…Other relevant studies have supported the idea that degenerative disc disorders may be genetically determined [9][10][11][12] . The first gene mutations associated with intervertebral disc degeneration in humans were reported in 1998 13) .…”
mentioning
confidence: 86%
“…There are three studies that show a familial predisposition [54,68,69]. An identical twin study showed that genetics was more important than occupational factors in determining disc degeneration [8].…”
Section: Geneticsmentioning
confidence: 99%
“…Disc degeneration, although in many cases asymptomatic (Boden et al, 1990), is also associated with sciatica and disc herniation. Although the etiology of disc degeneration is unknown, it has been suggested that genetic factors contribute to the development of lumbar degenerative disc disease (LDDD; Zamani and MacEwen, 1982;Simmons Jr. et al, 1996;Richardson et al, 1997). Epidemiological studies have shown that a family history of intervertebral disc herniation is a risk factor for juvenile herniation and significantly affects the probability of LDDD (Matsui et al, 1990(Matsui et al, , 1992(Matsui et al, , 1998.…”
Section: Introductionmentioning
confidence: 99%