In the field of upper-limb myoelectric prosthesis control, the use of statistical and machine learning methods has been long proposed as a means of enabling intuitive grip selection and activation; yet, clinical adoption remains rather limited. One of the main causes hindering clinical translation of machine learning-based prosthesis control is the requirement for a large number of electromyography (EMG) sensors. Here, we propose an end-to-end strategy for multi-grip, classification-based prosthesis control using only two sensors, comprising EMG electrodes and inertial measurement units (IMUs). We emphasise the importance of accurately estimating posterior class probabilities and rejecting predictions made with low confidence, so as to minimise the rate of unintended prosthesis activations. To that end, we propose a confidence-based error rejection strategy using grip-specific thresholds. We evaluate the efficacy of the proposed system with real-time pick and place experiments using a commercial multi-articulated prosthetic hand and involving 12 able-bodied and two transradial (i.e., below-elbow) amputee participants. Results promise the potential for deploying intuitive, classification-based multi-grip control in existing upper-limb prosthetic systems. opening/closing 3-5 , and has recently found its way to commercial adoption 3,4 . Several studies have also used this paradigm to decode grips and gestures for intuitive prosthetic hand control. In their majority, however, they have been either limited to offline analyses 6-8 or only included able-bodied participants 9-11 , with few exceptions demonstrating real-time control with amputees 12, 13 .One caveat of classification-based myoelectric control is the requirement for a relatively large number of sensors 14, 15 or high-density electrode arrays 16,17 . This requirement increases the overall complexity and cost of the system and reduces its practicality, due to increased weight and the burden associated with a constant need for positioning a large number of electrodes. Minimising the number of electrodes used in a myoelectric control system has been identified as one of the main challenges in the field 1 . Hence, a significant body of work has previously investigated means of achieving this goal. Exhaustive search or sequential selection algorithms have been used to identify a suitable subset from a larger pool of sensors, typically in the range 4-12 12, 18-28 . Despite previous efforts, the feasibility of using a single pair of sensors, which is typically available in commercial prostheses, to control a multi-grip prosthetic hand has yet to be demonstrated.Drastically reducing the amount of sensors used for myoelectric control may lead to a decrease in classification performance. Additionally, it has been reported that unintended prosthesis motions can lead to user frustration 29 , which in turn may increase the risk of prosthesis rejection. To ensure user satisfaction, it is imperative to design fault-tolerant myoelectric controllers with the ability to rejec...