Abstract-Complementary to the conventional class-E topology, inverse class-E operation has several advantages over the class-E counterpart, such as lower peak switch voltage and smaller circuit inductance, which are attractive to high power RF design and MMIC implementation. This paper derives the closed-form design equations that can be used to synthesize the idealized operation of inverse class-E power amplifiers at any switch duty ratio. Calculation of the key design parameters, such as the maximum switch voltage and circuit components values, is elaborated and compared with the case of conventional class-E operation. Further, the theoretical analysis is confirmed and verified by numerical simulations performed on a 500 mW, 2.4 GHz idealized inverse class-E power amplifier.