A G-Quartet Formed in the Absence of a Templating Metal Cation: A New 8-(N,N-dimethylaniline)guanosine Derivative

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

“…1f). This structural arrangement is consistent with the self-assembly of previously reported guanosine/deoxy-guanosine derivatives in the absence of any templating cation 46,47 .…”

“…This non-planar tetrameric arrangement has the look of four-stranded topology obtained by natural/synthetic G-quartets ( Fig. 2d) 47,50,51 . Among the four inter-molecularly hydrogen bonded Fmoc-G-PNA conjugates responsible for tetramer formation, the fluorenylmethyl part of two molecules occupies the space either above or below the tetramer plane, with the hydrophobic tail pointing outwards from the cavity.…”

The conformational effect of para-substituted C8-arylguanine adducts on the B/Z-DNA equilibrium

“…Guanosine and guanosine derivatives are known to form gels. Gel formation usually requires the presence of a metal cation though there is at least one report of a modified guanosine that forms a G-quartet in the absence of a metal cation [43]. After synthesis and FPLC purification, oligonucleotides were obtained in 30-40% yield (~89%/base).…”

Nichtkovalente Synthese mit Wasserstoffbrücken

“…[207,208] Weiterhin wurde gezeigt, dass K -Ionen die Stapelung zweier Tetramere zu einer octameren Struktur induzieren, deren exakte molekulare Struktur durch NMR bestätigt wurde. [215] In diesem Fall nimmt man an, dass periphere Aryleinheiten das Tetramer gegenüber bandartigen Strukturen stabilisieren. [212] Die Bindung einwertiger Metallionen konnte durch 205 Tl-NMR [213] und ESI-MS [214] direkt nachgewiesen werden.…”