A Gastric Secretion Test in the Intact Guinea-Pig

Capoferro, R.; Torgersen, O

doi:10.3109/00365527109180721

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…In the present experiments, no choleresis was recorded either in rabbits or guinea pigs after infusing pentagastrin in doses necessary to stimulate maximum gastric acid secretion. This is perhaps not surprising in view of the insensitivity of the stomachs of herbivores to infusion of gastrin [Shaw and Heath, 1972;Capoferro and Torgersen, 1971].…”

Section: Effects Of Pentagastrinmentioning

confidence: 99%

Regulation of Bile Formation in Rabbits and Guinea Pigs

Shaw

Heath

1974

Exp Physiol

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Despite interruption of the enterohepatic circulation of bile salts, bile flow in conscious rabbits and guinea pigs remained constant for several hours when saline was infused to compensate for loss of water and electrolytes in bile. Thus it appeared that biliary flow in these species is not as highly dependent on bile salt secretion as it is in dogs and man. The effects of other stimulants known to play an important role in regulating bile formation in other species were tested in rabbits and guinea pigs. Secretin, cholecystokinin-pancreozymin (CCK-PZ) and gastrin proved to be ineffective choleretics in rabbits although the doses of these exogenously-administered hormones were sufficient to siguificantly increase either pancreatic or gastric secretion. Trivial choleretic responses were recorded after administration of secretin and CCK-PZ to guinea pigs. Attempts were then made to elicit a choleresis by release of endogenous hormones. Again no changes in bile formation were recorded in rabbits although pancreatic secretion was stimulated. Bile flow in guinea pigs increased slightly, but the degree of duodenal acidification necessary to produce all of these responses to endogenous secretin release was probably unphysiological. Attempts to stimulate the release of endogenous CCK-PZ by infusing peptone were unsuccessful. It was concluded that if these herbivores do elaborate secretin and CCK-PZ, the factors responsible for their release may differ from those in other species. The present findings provide further evidence that the control of bile formation in rabbits and guinea pigs differs from that in other species, and it is possible that these differences could be related to the temporal pattern of their eating habits.According to Sperber [1965], bile secretion in many species is mainly due to active secretion of bile salts into the canaliculi and the subsequent osmotic flow of water. However, the primacy of bile salt secretion in the regulation of bile flow of herbivores such as rats and rabbits has been questioned by Klaassen [1972] and Erlinger, Dhumeaux, Berthelot and Dumont [1970]. Gastrointestinal hormones, particularly secretin, may also be important in the regulation of bile formation in dogs [Jones, Geist and Hall, 1971], cats [Scratcherd, 1965] and man [Konturek, Dabrowski, Adamozyk and Kulpa, 1969]. However, it would appear from the small amount of information existing on the subject, that herbivores, at least the non-ruminant type, may be relatively insensitive to the effects of gastrointestinal hormones [Scratcherd, 1965;Shaw and Heath, 1972]. It has been suggested that the failure of secretin to act as a choleretic agent in rabbits may be associated with the very high spontaneous rate of bile formation in this species [Scratcherd, 1965].The present study was designed to provide more information on the regulation of bile formation in conscious rabbits and guinea pigs, two species which have the highest rates of bile formation known.

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Section: Effects Of Pentagastrinmentioning

confidence: 99%

Regulation of Bile Formation in Rabbits and Guinea Pigs

Shaw

Heath

1974

Exp Physiol

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“…Further, the high catabolic activity in the guinea-pig stomach might be adverse to the possibilities for histamine to exert its stimulatory action (see also Lorentz, Pfleger & Werle, 1967). J. BERGMARK AND OTHERS However, it should be realized that the guinea-pig parietal cell is very sensitive to exogenous histamine (Ragins & Wincze, 1969;Capoferro & Torgersen, 1971;Kowalewski, 1974). In addition, the high methylating capacity and also the reported oxidative deamination (Dworetzky & Code, 1951;Lorentz et al 1967) might serve an important role in protecting this sensitive species from histamine which otherwise would have reached the blood stream.…”

Section: Discussionmentioning

confidence: 99%

Histamine metabolism of the guinea‐pig gastric mucosa.

Bergmark¹,

Granérus²,

Henningsson³

et al. 1976

The Journal of Physiology

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1. The mobilization of gastric mucosal histamine as reflected by changes in formation and content has been studied in guinea‐pigs on feeding and after injections of pentagastrin or 2‐deoxy‐D‐glucose. 2. Re‐feeding fasting guinea‐pigs as well as injections of pentagastrin or 2‐deoxy‐D‐glucose raised the rate of mucosal histamine formation; pentagastrin induced a fourfold rise. 3. Some properties of the enzyme catalysing the formation of histamine were examined. The results indicated that this enzyme is histidine decarboxylase, L‐histidine carboxy‐lyase, E.C. 4.1.1. 22. 4. The enzyme imidazole‐N‐methyl transferase, E.C. 2.1.1.8, which carries out methylation of the imidazole ring to yield 1‐methyl‐4‐(beta‐aminoethyl)imidazole (methylhistamine), was found in high amounts in the mucosa. The enzyme did not change upon stimulation of the mucosa. 5. The metabolism of histamine within the gastric mucosa is discussed in relationship to a suggested role of the amine in exciting acid secretion.

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“…were used. The animals were szbmitted to a training program for a previously described secretion test (3).…”

Section: Anirncilsmentioning

confidence: 99%

The Effect of X-Irradiation on Gastric Secretion in the Intact Guinea-Pig

Capoferro

1972

Scandinavian Journal of Gastroenterology

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Volume, pH, and total acidity of the basal and of the stimulated gastric secretion were measured in guinea-pigs before, and at appropriate intervals after, x-irradiation to the stomach area. A great reduction of the stimulated acidity and acid output was found. It reached a maximum between the second and the fourth week after irradiation. Thereaftcr the total acidity increased gradually. but, 56 weeks after irradiation, it still remained significantly below the normal (p < 0.05). The volume was lowered to a lesser extent.Scand J Gastroenterol Downloaded from informahealthcare.com by University of Calgary on 02/02/15For personal use only.

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A Gastric Secretion Test in the Intact Guinea-Pig

Cited by 7 publications

References 7 publications

Regulation of Bile Formation in Rabbits and Guinea Pigs

Regulation of Bile Formation in Rabbits and Guinea Pigs

Histamine metabolism of the guinea‐pig gastric mucosa.

The Effect of X-Irradiation on Gastric Secretion in the Intact Guinea-Pig

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