A genetic study of febrile convulsions

Frantzen, E; Lennox-Buchthal, Margaret A.; Nygaard, A; Stene, Jon

doi:10.1212/wnl.20.9.909

Cited by 105 publications

(54 citation statements)

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“…According to Webb et al only 10% developed epilepsy later on in this age category 4 . Twenty five percent had an affected first degree relative with febrile convulsions and it is comparable to the available information in the literature 5,6,7,8 .…”

Section: Discussionsupporting

confidence: 80%

A survey on febrile seizures at the Lady Ridgeway Hospital for Children

Liyanage¹,

Silva²,

Perera

2009

Sri Lanka J Child Health

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Section: Discussionsupporting

confidence: 80%

A survey on febrile seizures at the Lady Ridgeway Hospital for Children

Liyanage¹,

Silva²,

Perera

2009

Sri Lanka J Child Health

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“…Thus, the segregation observed in the pedigrees (unilateral recurrence, affected patients distributed through several generations, males and females almost equally affected) seems to be more compatible with an autosomal dominant mechanism of inheritance, with incomplete and probably low penetrance, which is in agreement with the findings of Frantzen et al 2 .…”

Section: Resultssupporting

confidence: 91%

Genetic predisposition to febrile convulsions: a preliminary study

Raffin

Giuoliani

Armbrust-Fgueiredo

1980

Arq. Neuro-Psiquiatr.

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The participation of genetic factors in convulsive disorders is a controversial subject. Some investigators consider it to be high and others low. Autosomal dominant, autosomal recessive, sex-linked recessive, and polygenic mechanims of inheritance have been proposed 4 ' 5 ' 6 .One of the factors that brings special difficulty to define the influence of heredity is the heterogeneous nature of the problem. In an attempt to isolate a supposedly more homogeneous group of patients, and to try to define wheter or not a genetic predisposition is present, we developed a study of subjects who had had febrile convulsions. Febrile convulsions was defined as an epileptic event ocurring in a previously normal child during a febrile illness unrelated to a nervous system disease 1 ' 3 ' 7 . MATERIAL, METHODS AND RESULTS Patients attending the Hospital das Clinicas, Faculdade de Medicina de RibeirãoPreto, USP, who had shown at least one well-characterized episode of febrile convulsion were referred to the Febrile Convulsions Ambulatory, and studied during the period of January to December, 1979. A complete family history was obtained in addition to clinical and laboratory data. Relatives with febrile convulsions were considered only when the report given left no margin for doubt. Of the 128 patients studied, 18 (14,3 % of the sample) had at least one relative affected by febrile convulsions.The pedigrees of these patients can be seen in figure 1. The age of the probands variei between 8 months and 16 years, with a mean age of 4 years and 6 months.Family recurrence was always unilateral (only on the paternal or only on the maternal side), which is not in agreement with a polygenic mechanism of inheritance 8.

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“…1 Provoking factors which have been studied are genetics, low birth weight, vaccinations and metabolic disturbances. [2][3][4][5][6][7][8][9] Risk of recurrence is directly proportional to number of risk factors. About one-third of children with a first FS will have a recurrence.…”

Section: Introductionmentioning

confidence: 99%