A gold nanoparticle coated porcine cholecyst-derived bioscaffold for cardiac tissue engineering

Nair, Reshma S.; Ameer, Jimna Mohamed; Alison, Malcolm R.; Anilkumar, T. V.

doi:10.1016/j.colsurfb.2017.05.056

Cited by 49 publications

(37 citation statements)

References 27 publications

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“…Recently, interest in nanotechnology has increased, such that some studies have attempted to modify different decellularized tissues, using several nanomaterials of various sizes and shapes, for multiple purposes [7][8][9]. Among these nanomaterials, the applications of noble metal nanoparticles, such as silver nanoparticles (AgNPs), have increased because of their unique characteristics [10].…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Saleh

Ahmed

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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No ideal cross-linking agent has been identified for decellularized livers (DLs) yet. In this study, we evaluated structural improvements and biocompatibility of porcine DLs after cross-linking with silver nanoparticles (AgNPs). Porcine liver slices were decellularized and then loaded with AgNPs (100 nm) after optimization of the highest non-toxic concentration (5 µg/mL) using Human hepatocellular carcinoma (HepG2) and EAhy926 human endothelial cell lines. The cross-linking effect of AgNPs was evaluated and compared to that of glutaraldehyde and ethyl carbodiimide hydrochloride and N-hydroxysuccinimide. The results indicated that AgNPs improved the ultra-structure of DLs' collagen fibres with good porosity and increased DLs' resistance against in vitro degradation with good cytocompatibility. AgNPs decreased the host inflammatory reaction against implanted porcine DL slices in vivo and increased the polarization of M2 macrophages. Thus, structural and functional improvements of Porcine DLs could be achieved using AgNPs.

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Section: Introductionmentioning

confidence: 99%

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Saleh

Ahmed

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…(for example, FePt, Fe 3 O 4 -Ag, Fe 3 O 4 -Au, and CdS-FePt), have been widely used in sensory devices [ 226 , 227 , 228 , 229 , 230 ]. Nanomaterials are functionalized to increase the efficiency of their binding to biomolecules [ 231 , 232 , 233 , 234 ] and to use the coating to form an analytical signal [ 235 , 236 ].…”

Section: Methods Of Sensors Characteristics Improvementmentioning

confidence: 99%

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

et al. 2018

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Analytical chemistry is now developing mainly in two areas: automation and the creation of complexes that allow, on the one hand, for simultaneously analyzing a large number of samples without the participation of an operator, and on the other, the development of portable miniature devices for personalized medicine and the monitoring of a human habitat. The sensor devices, the great majority of which are biosensors and chemical sensors, perform the role of the latter. That last line is considered in the proposed review. Attention is paid to transducers, receptors, techniques of immobilization of the receptor layer on the transducer surface, processes of signal generation and detection, and methods for increasing sensitivity and accuracy. The features of sensors based on synthetic receptors and additional components (aptamers, molecular imprinted polymers, biomimetics) are discussed. Examples of bio- and chemical sensors’ application are given. Miniaturization paths, new power supply means, and wearable and printed sensors are described. Progress in this area opens a revolutionary era in the development of methods of on-site and in-situ monitoring, that is, paving the way from the “test-tube to the smartphone”.

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“…AuNPs were conjugated to cholecyst derived xenogenic ECM, by means 1-ethyl-3-(3-dimethyl aminopropyl)-carbodiimide/N-hydroxysuccinimide method. The modified scaffold allowed the growth and proliferation of the cardiomyoblasts (H9c2 cells) and the introduction of AuNPs provided a conductivity property to the scaffold useful for improving cell communication and controlling the polarity of cells [45].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

et al. 2020

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To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly relevant area of experimental study enclosing both nanotechnology and cardiac regeneration, e.g., nanoparticle applications in cardiac tissue engineering, is also discussed.

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A gold nanoparticle coated porcine cholecyst-derived bioscaffold for cardiac tissue engineering

Cited by 49 publications

References 27 publications

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Silver nanoparticles improve structural stability and biocompatibility of decellularized porcine liver

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

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