A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(ϵ-caprolactone) nanoparticles in aqueous solution

Wu, Chi; Jim, Tsz Fung; Gan, Zhihua; Zhao, Yue; Wang, Shengzhe

doi:10.1016/s0032-3861(99)00586-8

Cited by 50 publications

(34 citation statements)

References 14 publications

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“…(2). This parameter is calculated by assuming perfect mixing between water and acetone, and by taking into account the dependence of the interfacial tension on the solution composition (see Fig.…”

Section: Resultsmentioning

confidence: 99%

Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Lince

Marchisio

2008

Journal of Colloid and Interface Science

214

169

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Section: Resultsmentioning

confidence: 99%

Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Lince

Marchisio

2008

Journal of Colloid and Interface Science

214

169

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“…The enzymatic degradation of PCL polymers has been investigated, especially in the presence of lipase-type enzymes (Mochizuki et al, 1995;Gan et al, 1997Gan et al, , 1999. Wu et al (2000) claimed that the presence of the microbial Pseudomonas lipase enhanced the degradation rate of PCL nanoparticles by a factor of 1000 as compared with their purely hydrolytic degradation. Highly crystalline PCL was reported to totally degrade in 4 days in the presence of Pseudomonas lipase.…”

Section: The Degradation Of Pcl/peg Copolymersmentioning

confidence: 99%

Biodegradable poly(ɛ-caprolactone)–poly(ethylene glycol) copolymers as drug delivery system

Wei

Gong

Gou

et al. 2009

International Journal of Pharmaceutics

331

191

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“…2 One of the most important use of PCL for pharmaceutical applications is the production of nanoparticles for drug delivery, a very promising application for human health.…”

Section: Introductionmentioning

confidence: 99%

Solvent Structuring and Its Effect on the Polymer Structure and Processability: The Case of Water–Acetone Poly-ε-caprolactone Mixtures

2014

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One of the most common processes to produce polymer nanoparticles is the solvent-displacement method, in which the polymer is dissolved in a "good" solvent and the solution is then mixed with an "anti-solvent". The polymer processability is therefore determined by its structural and transport properties in solutions of the pure solvents and at the intermediate compositions. In this work, we focus on poly-ε-caprolactone (PCL) which is a biocompatible polymer that finds widespread application in the pharmaceutical and biomedical fields, performing full atomistic molecular dynamics simulations of one PCL chain of different molecular weight in a solution of pure acetone (good solvent), of pure water (antisolvent), and their mixtures. Our simulations reveal that the nanostructuring of one of the solvents in the mixture leads to an unexpected identical polymer structure irrespectively of the concentration of the two solvents. In particular, although in pure solvents the behavior of the polymer is, as expected, very different, at intermediate compositions, the PCL chain shows properties very similar to those found in pure acetone as a result of the clustering of the acetone molecules in the vicinity of the polymer chain. We derive an analytical expression to predict the polymer structural properties in solution at different solvent compositions and show that the solvent clustering affects in an unpredictable way the polymer diffusion coefficient. These findings have important consequences on the optimization of the nanoparticle production process and in the implementation of continuum modeling techniques to model it.

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A heterogeneous catalytic kinetics for enzymatic biodegradation of poly(ϵ-caprolactone) nanoparticles in aqueous solution

Cited by 50 publications

References 14 publications

Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

Biodegradable poly(ɛ-caprolactone)–poly(ethylene glycol) copolymers as drug delivery system

Solvent Structuring and Its Effect on the Polymer Structure and Processability: The Case of Water–Acetone Poly-ε-caprolactone Mixtures

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