A High Level of Colony‐Stimulating Activity in a Lung Cancer Patient with Extensive Leucocytosis, and the Establishment of a CSA Producing Cell Line (KONT)

Abstract

Colony-stimulating activity (CSA) was demonstrated in materials taken from a patient suffering from lung cancer associated with excessive leucocytosis. CSA was detected not only in his urine, serum and pleural effusion but also in the supernatant of cell cultures originating from the effusion. The excessive leukocytosis of the patient might be due to a CSA producing tumor. A cell line (KONT) originating from the CSA producing tumor has been maintained for 4 years and shown to produce mouse-and human-CSA. ABBREVIATIONSCM = conditioned medium CRP = c-reactive protein CSA = colony stimulating activity

Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: Report of a case

“…Cases of carcinoma of the lung, stomach, liver, gallbladder, and pancreas associated with the production of granulocyte-colony stimulating factor (G-CSF) have been reported. [1][2][3][4][5][6] Granulocytecolony stimulating factor-producing tumors are associated with an increase in the white blood cell count, rapid disease progression, and a poor prognosis. Moreover, the number of reports of tumors producing G-CSF is increasing.…”

Pancreatic carcinoma associated with marked eosinophilia: A case report

“…During the last decade, many cases of CSF-producing neoplasm have been reported (9-12), following the initial report of CSF-producing lung carcinoma by Asano et a1 (1 3). Further, many CSF-producing cell lines have been established (8,9,14,15), of which a few were derived from pancreatic carcinoma (8, 14). But it was not known whether these pancreatic carcinomas produced CSF in vivo.…”