A high serum-free fatty acid level is associated with cancer

Zhang, Lili; Han, Lei; He, Juan; Lv, Jing; Pan, Rongfang; Lv, Teng

doi:10.1007/s00432-019-03095-8

Cited by 46 publications

(32 citation statements)

References 30 publications

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“…It is well documented that circulating FFAs act as signaling molecules, are fundamental components of cellular structures, and are important sources of energy [24], and many studies demonstrated the association between altered FFA levels and different pathological conditions, such as inflammatory and cardiovascular diseases, neurological disorders, and cancer [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Free Fatty Acids Signature in Human Intestinal Disorders: Significant Association between Butyric Acid and Celiac Disease

et al. 2021

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Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs), medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with metabolic, gastrointestinal, and malignant diseases. Hence, we compared the serum FFA profile of patients with celiac disease (CD), adenomatous polyposis (AP), and colorectal cancer (CRC) to healthy controls (HC). We enrolled 44 patients (19 CRC, 9 AP, 16 CD) and 16 HC. We performed a quantitative FFA evaluation with the gas chromatography–mass spectrometry method (GC–MS), and we performed Dirichlet-multinomial regression in order to highlight disease-specific FFA signature. HC showed a different composition of FFAs than CRC, AP, and CD patients. Furthermore, the partial least squares discriminant analysis (PLS-DA) confirmed perfect overlap between the CRC and AP patients and separation of HC from the diseased groups. The Dirichlet-multinomial regression identified only strong positive association between CD and butyric acid. Moreover, CD patients showed significant interactions with age, BMI, and gender. In addition, among patients with the same age and BMI, being male compared to being female implies a decrease of the CD effect on the (log) prevalence of butyric acid in FFA composition. Our data support GC–MS as a suitable method for the concurrent analysis of circulating SCFAs, MCFAs, and LCFAs in different gastrointestinal diseases. Furthermore, and notably, we suggest for the first time that butyric acid could represent a potential biomarker for CD screening.

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Section: Discussionmentioning

confidence: 99%

Free Fatty Acids Signature in Human Intestinal Disorders: Significant Association between Butyric Acid and Celiac Disease

et al. 2021

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“…The AUC of the ROC curves of the combined measurement of pre-NRCT PON1 and α-ketoglutarate concentrations in the distinction between patients with RC and healthy subjects was 0.918, which compared favourably with other biomarkers studied in recent years. For example, an AUC of 0.81 has been reported for a panel of 5 methylated microRNAs [ 42 ], while for the determination of small proline-rich protein 2A it was 0.851 [ 43 ], for urinary 8-OH-guanosine it was 0.755 [ 44 ], and for free fatty acids it was 0.61 [ 45 ]. From this perspective, our results suggest that the measurement of PON1 and α-ketoglutarate concentrations pre-NRCT could be a useful tool for the early diagnosis of RC.…”

Section: Discussionmentioning

confidence: 99%

Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy

et al. 2021

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We report a pilot study on the feasibility of determinations of circulating levels of paraoxonase-1 (PON1) and compounds related to energy metabolism as biomarkers for the evaluation of patients with rectal cancer (RC), and the effects produced by neoadjuvant radiochemotherapy (NRCT). We studied 32 patients treated with radiotherapy plus capecitabine concomitant chemotherapy and 48 control subjects. We identified pre-NRCT PON1 and α-ketoglutarate as the parameters that best discriminated between RC patients and the control group. Receiver operating characteristics analysis of the combination of the two parameters showed an area under the curve (AUC) of 0.918. Moreover, patients who presented a pathological complete response (pCR) to treatment had lower plasma pre-NRCT valine concentrations (AUC of 0.826). Patients who had a relapse had lower concentrations of succinate (AUC of 0.833). The results of the present study illustrate the usefulness of investigating alterations in oxidative stress and metabolism in RC. Due to the small number of patients studied, our results must be considered preliminary, but they suggest that the determination of circulating levels of PON1 and α-ketoglutarate might be a valuable tool for the early diagnosis of RC, while the determination of valine and succinate might effectively predict pCR and the appearance of relapse.

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“…Moreover, Zhang 21 et al demonstrated that the serum levels of FCH (free cholesterol) were significantly higher in patients with colorectal cancer than in patients with benign colorectal disease and healthy participants, which indicated that FCH has a potential role in the early diagnosis of CRC, consistent with our results; however, the FFA level was not detected in Xin Zhang’s study, ROCs of FCH and other lipids were not drawn, and the diagnostic performance of FCH was unclear. In interest, Zhang 22 et al detected FFA levels to investigate whether FFAs are meaningful in cancer patients and found that AUCs in rectal cancer and colon cancer distinguishing noncancer patients (without patients with CA) were 0.614 and 0.599, respectively, which indicated a comparatively general diagnostic value; however, it was found that FFAs not only have the value of early diagnosis of CRC but also have good complementary efficacy with CEA and CA19-9 (expressed in CRC tissues), and the combined detection can improve the early diagnostic ability in our study, the AUC of which is 0.801 and larger than Lili Zhang’s result.…”

Section: Discussionmentioning

confidence: 99%

Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study

Zhu

Zhang

Zheng

et al. 2021

CMAR

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The aim of our study was to identify the diagnostic ability of free fatty acids (FFAs) in younger colorectal cancer (CRC) patients by comparing carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9). Methods: Patients screened for CRC at Fujian Medical University Union Hospital from January 2011 to December 2014 were recruited. Patients pathologically diagnosed with CRC or colorectal adenoma (CA) and healthy control participants were included. The enzyme endpoint method was applied to measure FFA levels. Receiver operating characteristic (ROC) curve analysis was performed to further evaluate the diagnostic ability of FFAs. Results: FFA levels in late-stage patients (tumour-node-metastasis (TNM) stages III-IV) were higher than those in early-stage patients (TNM stages I-II) (P=0.02). The FFA levels in CRC patients were higher than those in controls of all ages, those younger than 50 years, males and females (P<0.001), and this difference was larger for patients younger than 50 years and females than for the all ages group. There was no significant difference in the FFA level between CA patients and healthy participants (P=0.53). The area under the curve (AUC) values of FFA, CEA, CA19-9, FFA+CEA, FFA+CA19-9 and FFA+CEA+CA19-9 distinguished CRC patients from controls at all ages, with values of 0.604, 0.731, 0.640, 0.754, 0.678 and 0.758, respectively; however, in the younger CRC patients (age≤50), the AUC values were 0.701, 0.735, 0.669, 0.798, 0.749, and 0.801. The AUC in female patients younger than 50 years was larger than that in males (0.769 vs 0.660), and this value was greater than the value for CEA in males (0.739) and females (0.729). Conclusion:The FFA level not only can complement the predictive ability of the CEA and CA19-9 levels but also has a superior predictive ability in female and younger patients with CRC. FFA levels may have a potential role in triage screening of early CRC.

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A high serum-free fatty acid level is associated with cancer

Cited by 46 publications

References 30 publications

Free Fatty Acids Signature in Human Intestinal Disorders: Significant Association between Butyric Acid and Celiac Disease

Free Fatty Acids Signature in Human Intestinal Disorders: Significant Association between Butyric Acid and Celiac Disease

Identification of potential metabolic biomarkers of rectal cancer and of the effect of neoadjuvant radiochemotherapy

Free Fatty Acid is a Promising Biomarker in Triage Screening for Patients with Colorectal Cancer: A Case–Control Study

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