A Higher Dose of Vitamin D Reduces the Risk of Falls in Nursing Home Residents: A Randomized, Multiple‐Dose Study

Broe, Kerry E; Chen, Thomas; Weinberg, Janice; Bischoff‐Ferrari, Heike A.; Holick, Michael F.; Kiel, Douglas P.

doi:10.1111/j.1532-5415.2007.01048.x

Cited by 377 publications

(250 citation statements)

References 32 publications

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“…Although the MV contained only 10 mg vitamin D 3 , it also contained 144 mg elemental calcium (360 mg calcium carbonate), plus a range of other micronutrients that may have had a positive effect on bone and risk of falling. A recent study has found a similar reduction in falls over a 5-month period with vitamin D alone, although their dose was twice as that used in our study (Broe et al, 2007). Further investigations are warranted using a MV supplement over a longer term to confirm these findings in relation to bone quality and rate of falls.…”

Section: Discussionsupporting

confidence: 50%

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

et al. 2007

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Objectives: To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility. Subjects: A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months. Results: A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean difference ± standard error, 33.4 ± 2.6 nmol l À1 ), folate (13.4 ± 2.8 nmol l À1 ), and vitamin B12 (178.0±40.3 pmol l À1 ) (all Po0.001). Adequate 25(OH)D concentrations (X50 nmol l À1 ) were found among 77% of participants in the MV group vs 10% taking P (Po0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.0±2.0 dB MHz À1 vs À2.9±2.1 dB MHz À1 , respectively, P ¼ 0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.3 ± 0.1 falls vs 0.8 ± 0.3 falls, P ¼ 0.078). Conclusions: MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.

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Section: Discussionsupporting

confidence: 50%

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

et al. 2007

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“…Dukas et al (99) , however, showed that only those with a Ca intake above 512 mg/d had a significant reduction in fall risk with alfacalcidol supplementation, suggesting that this may be an important area of research. A number of studies also compared Ca v. Ca and vitamin D, showing vitamin D 2 or vitamin D 3 and Ca to be significantly more effective in reducing falls than Ca alone (97,103) . Also, few studies with regard to muscle strength and fall risk have been conducted in an Australian setting, which is disappointing when considering the enormous health burden that falls and osteoporosis places on this country.…”

Section: Vitamin D and Muscle Strengthmentioning

confidence: 99%

Vitamin D in health and disease: an insight into traditional functions and new roles for the ‘sunshine vitamin’

Borradale

Kimlin

2009

Nutr. Res. Rev.

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Vitamin D is unique among the vitamins in that man can synthesise it via the action of UV radiation upon the skin. This combined with its ability to act on specific target tissues via vitamin D receptors (VDR) make its classification as a steroid hormone more appropriate. While vitamin D deficiency is a recognised problem in some northern latitude countries, recent studies have shown that even in sunny countries, such as Australia, vitamin D deficiency may be more prevalent than first thought. Vitamin D is most well known for its role in bone health; however, the discovery of VDR on a wide variety of tissue types has also opened up roles for vitamin D far beyond traditional bone health. These include possible associations with autoimmune diseases such as multiple sclerosis and inflammatory bowel diseases, cancer, CVD and muscle strength. First, this paper presents an overview of the two sources of vitamin D: exposure to UVB radiation and food sources of vitamin D, with particular focus on both Australian and international studies on dietary vitamin D intake and national fortification strategies. Second, the paper reviews recent epidemiological and experimental evidence linking vitamin D and its role in health and disease for the major conditions linked to suboptimal vitamin D, while identifying significant gaps in the research and possible future directions for research.

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“…Vitamin D (combined with calcium supplementation) enhances lower extremity function, increases BMD, and reduces fall and fracture risk in older individuals. (9)(10)(11)(12)(13) In addition to the established role of vitamin D and calcium supplementation, load-bearing training, including whole-body vibration (WBV) training, may prevent or even partially reverse sarcopenia and osteoporosis in community-dwelling postmenopausal women. (14)(15)(16)(17) During WBV training, the individual stands on a platform that generates vertical sinusoidal vibrations.…”

mentioning

confidence: 99%

The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: A 6-month randomized, controlled trial

Verschueren

Bogaerts

Delecluse

et al. 2010

Journal of Bone and Mineral Research

120

104

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Sarcopenia and osteoporosis represent a growing public health problem. We studied the potential benefit of whole-body vibration (WBV) training given a conventional or a high dose of daily vitamin D supplementation in improving strength, muscle mass, and bone density in postmenopausal women. In a 2 Â 2 factorial-design trial, 113 institutionalized elderly females aged over 70 years (mean age 79.6 years) were randomly assigned either to a WBV or a no-training group, receiving either a conventional dose (880 IU/day) or a high dose (1600 IU/day) of vitamin D 3 . The primary aim was to determine the effects of 6 months of WBV and/or vitamin D supplementation on isometric and dynamic strength, leg muscle mass, and hip bone mineral density (BMD). Additionally, the increase in 25-hydroxyvitamin D [25(OH)D] levels between conventional and high-dose supplementation was compared. After 6 months of treatment, dynamic muscle strength, hip BMD, and vitamin D serum levels improved significantly in all groups, whereas isometric strength and muscle mass did not change. When compared with no training, the WBV program did not result in additional improvements. When compared with 880 IU, a high dose of 1600 IU of vitamin D did result in higher serum vitamin D levels but did not result in additional improvements. In institutionalized women older than 70 years, the WBV training protocol tested is not more efficient in enhancing muscle mass, strength, and hip BMD compared with vitamin D supplementation. A higher dose of 1600 IU of vitamin D does not provide additional musculoskeletal benefit in this population compared with conventional doses. ß

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A Higher Dose of Vitamin D Reduces the Risk of Falls in Nursing Home Residents: A Randomized, Multiple‐Dose Study

Cited by 377 publications

References 32 publications

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Vitamin D in health and disease: an insight into traditional functions and new roles for the ‘sunshine vitamin’

The effects of whole-body vibration training and vitamin D supplementation on muscle strength, muscle mass, and bone density in institutionalized elderly women: A 6-month randomized, controlled trial

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