A histopathological outlook on nephrotic syndrome: A pediatric perspective

Arif, Mizna; Amjad, Nasser Mohammad

doi:10.4103/0971-4065.159555

Cited by 17 publications

(13 citation statements)

References 17 publications

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“…Histopathological patterns in some studies from other geographical locations are presented in (Table 2). [10][11][12][13][14][15] Arif et al 11 Absar et al 12 Bakr et al 13 Asinobi et al 14 Incidence of focal segmental glomerulosclerosis (FSGS) is observed to be increasing over the years in Pakistan. 11,12,15 Geographical variation seems to be significant contributors for the different histopathological findings of nephrotic syndrome in children.…”

Section: Resultsmentioning

confidence: 99%

Renal biopsy in children with nephrotic syndrome: a study of histopathological pattern

Joshi¹,

Joshi

2019

Int J Contemp Pediatr

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Background: Idiopathic nephrotic syndrome (INS) is a common childhood renal disease characterized by a remitting and relapsing course, associated with different histopathological subtypes. The true incidence of various histopathological subtypes of NS remains under estimated owing to the diversity in indication criteria for performing renal biopsies in pediatric population.Methods: This was a cross-sectional observational study in children with nephrotic syndrome at a tertiary health care centre. Total 22 children, with nephrotic syndrome, who underwent renal biopsy procedure during a period of one year, were enrolled for the study. Indications of renal biopsy were noted, and the histopathology reports were studied in detail.Results: In this study group, the most common indication for renal biopsy was “Atypical age (> 8years) of diagnosis in 45.5% (10/22) patients, followed by 22.7% (5/22) in “Children presenting with hypertension and hematuria”.The most common histopathological finding in these children was mesangial proliferative glomerulonephritis in 45.5% (10/22) patients followed by IgA nephropathy with mesangial proliferation in 22.72% (5/22) and minimal change disease in only 13.6% (3/22).Conclusions: This study highlights the occurrence of non-MCD as the common cause of INS in the children and denotes the significance of performing renal biopsies in children with INS for better prognostication.

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Section: Resultsmentioning

confidence: 99%

Renal biopsy in children with nephrotic syndrome: a study of histopathological pattern

Joshi¹,

Joshi

2019

Int J Contemp Pediatr

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“…Saudi Arabia (10.6 years) [18], India (7.9 years) [19], Pakistan (11.2 years) [20], Croatia (10 years) [7], other studies have revealed an earlier age at diagnosis [21].…”

Section: Discussionmentioning

confidence: 99%

Histopathological findings in children with idiopathic nephrotic syndrome in Honduras, 2016-2020

Galeas¹,

Alas-Pineda²,

Gaitán-Zambrano

2022

Preprint

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Background: Idiopathic nephrotic syndrome is the most common kidney disease in children, it is characterized by the presence of massive proteinuria, edema, hypoalbuminemia and hyperlipemia and can be caused by different histopathological subtypes. Methodology: Descriptive cross-sectional observational study. Histopathological and clinical data were collected from 52 pediatric patients with idiopathic nephrotic syndrome who underwent USG-guided kidney biopsy in two third level hospitals in northwestern Honduras during January 2016 to December 2020. Convenience sampling was used; the data was exported to SPSS v.25 statistical program, where statistical analysis was performed. Descriptive statistics were used to obtain the frequencies and percentages of the categorical variables, and the median and the interquartile range (IQR) of the quantitative variables were obtained. Results: the median age was 9 years [IQR, 3.0 - 12.0]; 55.8% were male. The clinical presentation of nephrotic syndrome in 34.6% of the cases was cortico-dependent nephrotic syndrome, followed by cortico-resistant nephrotic syndrome in 36.5%. The main subtype of glomerulopathy presented was the minimal change disease in 36.5%, followed by 28.8% corresponding to focal and segmental glomerulosclerosis. Conclusions: In Honduras the real incidence of the different histopathological variations is unknown, therefore kidney biopsy becomes a fundamental tool to establish the diagnosis, treatment and prognosis of the disease.

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“…MesPGN refers to a rare group of diseases identified histologically by mesangial and/or endocapillary hypercellularity, with the splitting of the GBM by extension of mesangium into the subendothelial space; MesPGN accounts for approximately 3–5% of primary renal causes of NS (Arif et al, 2016). Only one study to date has looked into the utility of microRNAs in MesPGN.…”

Section: Mirnas In Fsgsmentioning

confidence: 99%

MicroRNAs in childhood nephrotic syndrome

Dhandapani

Venkatesan

Charmine

2021

Journal Cellular Physiology

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The discovery of microRNAs (miRNAs) has opened up new avenues of research to understand the molecular basis of a number of diseases. Because of their conservative feature in evolution and important role in the physiological function, microRNAs could be treated as predictors for disease classification and clinical process based on the specific expression. The identification of novel miRNAs and their target genes can be considered as potential targets for novel drugs. Furthermore, currently, the circulatory and urinary exosomal miRNAs are gaining increasing attention as their expression profiles are often associated with specific diseases, and they exhibit great potential as noninvasive or minimally invasive biomarkers for the diagnosis of various diseases. The remarkable stability of these extracellular miRNAs circulating in the blood or excreted in the urine underscored their key importance as biomarkers of certain diseases. There is voluminous literature concerning the role of microRNAs in other diseases, such as cardiovascular diseases, diabetic nephropathy, and so forth. However, little is known about their diagnostic ability for the pediatric nephrotic syndrome (NS). The present review article highlights the recent advances in the role of miRNAs in the pathogenesis and molecular basis of NS with an aim to bring new insights into further research applications for the development of new therapeutic agents for NS.

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A histopathological outlook on nephrotic syndrome: A pediatric perspective

Cited by 17 publications

References 17 publications

Renal biopsy in children with nephrotic syndrome: a study of histopathological pattern

Renal biopsy in children with nephrotic syndrome: a study of histopathological pattern

Histopathological findings in children with idiopathic nephrotic syndrome in Honduras, 2016-2020

MicroRNAs in childhood nephrotic syndrome

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