A Huge Primary Ovarian Leiomyoma with Degenerative Changes-An Unusual Presentation

Abstract

Primary ovarian leiomyoma is a rare benign tumour of the ovary, which is seen in women who are aged between 20 years to 65 years. Ovarian leiomyomas can be confused with other spindle cell tumours which display gross anatomical and histological similarities. A case of a primary leiomyoma of the ovary in a pre-menopausal female is being presented here, due to its huge size and unusual presentation.

Primary ovarian leiomyoma in a postmenopausal woman: A case report

“…Primary ovarian myoma should be inside the ovary without coexistent uterine myomas. However, this coexistence has been reported by many researchers [1]. The present patient had a hysterectomy 16 years previously.…”

Coexisting leiomyomata peritonealis disseminata and ovarian leiomyoma

“…[4] Abnormal hormonal environment seems to play a role and this explains why this condition is seen in women of reproductive age group with many of them discovered during pregnancy,[234] with estrogen stimulating the mesenchymal cells to differentiate into fibroblasts, myofibroblasts, and smooth muscle. [56] Most of the patients also have concomitant uterine leiomyomas. It may arise in the setting of estrogen-secreting ovarian tumors.…”

“…[4] Ovarian leiomyoma is an extremely rare tumor of the ovary with only sixty cases reported in literature. [567] Association of LPD with ovarian leiomyoma has not been reported in literature. The present case was a 42-year-old lady who had coexisting ovarian leiomyoma with LPD, with total hysterectomy for uterine leiomyomas done 6 years back.…”

“…Exposure to exogenous hormones, hormone-secreting ovarian tumors, development after laparoscopic morcellation of myomas are the other factors that are described in the development of LPD. [56] The presence of ER and PR has been described in LPD and spontaneous regression noted after menopause. The retroperitoneal and mesenteric nodules and left ovary in our case showed whorls and fascicles of smooth muscle cells with cystic and myxoid degeneration.…”

Primary ovarian leiomyoma: a diagnostic dilemma

“…It accounts for 0.5-1% of all benign ovarian tumor. 1 Ovarian leiomyoma is particularly unilateral and small but they may reach big size upto 11 kg. It usually occurs in premenopausal women most of these tumors are discovered incidently.…”