A Human Blood Group Antigen, Nya (Nyberg), segregating with the Ns Gene Complex of the MNSs System

The low‐frequency MNS blood group antigens Nya (MNS18) and Osa (MNS38) are associated with GPA amino acid substitutions

“…Family studies have shown that Ny a is controlled by a gene at the MNS complex locus 3,5–7 . The sensitivity of Ny a to treatment of the RBCs with trypsin suggested that Ny a is on GPA, specifically, on that region of GPA encoded by exons 2 or 3.…”

“…Ny a (MNS18) is present on the RBCs of almost 0.2 percent of Norwegians, 5–7 yet only one Ny(a+) person was found in the screening of many thousands of European, white American, and Asian blood donors 3 . In 19 Norwegian families and 1 Swiss family, Ny a was inherited with an Ns haplotype 3,5–7 .…”

Studies on the Ny^a Blood Group Antigen and Antibodies

“…Ôrjasaeter During recent years the following low frequency blood group antigens have been added to those which belong to the MNSs system: Mu, Sta, Ria, Mta, Cla, and Nya [2,3,6,8,10,11]. Further information about these antigens will be of great interest, especially from the genetic point of view, but more knowledge of their serology and clini cal importance is also desirable.…”

First Example of Nya Blood Group Antigen in American Population

“…Nyberg (Nya), a blood group antigen in the MNSs system, was first described by Orjasaeter and associates in 1964 [8,7]. It was shown to belong to the MNSs system, where the Nya gene showed alignment with the Ns gene complex.…”