A hydrocellular foam dressing versus gauze: effects on the healing of rat excisional wounds

Kunugiza, Yasuo; Tomita, Tadahiro; Moritomo, Hisao; Yoshikawa, Hiroshi

doi:10.12968/jowc.2010.19.1.46093

Cited by 12 publications

(15 citation statements)

References 20 publications

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“…Dry scabbing delays the epithelialization of wounds (Kunugiza, Tomita, Moritomo, & Yoshikawa, 2010), and epidermal regeneration can be accelerated by the maintenance of a moist wound (Winter, 1962). This finding indicates that topical insulin cream may promote wound healing by accelerating epithelialization.…”

Section: Discussionmentioning

confidence: 92%

Effect of Topical Insulin on Second-Degree Burns in Diabetic Rats

Azevedo

Pessoa

Moreira

et al. 2015

Biological Research For Nursing

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The healing process is complex in diabetic wounds, and the healing mechanism of burn wounds is different from that of incisional or excisional wounds. Data from our previous study indicated that topical insulin cream reduced wound closure time in diabetic rats. Our aim was to investigate the effect of topical insulin cream on wound healing following second-degree burns in control and diabetic rats. Rats were divided into four groups: control (nondiabetic) rats treated with placebo (CP), control (nondiabetic) rats treated with topical insulin cream (CI), diabetic rats treated with placebo (DP), and diabetic rats treated with topical insulin cream (DI). The wounds were assessed at 4 time points (1, 7, 14, and 26 days) post-wounding for morphometric analysis of wound sections stained with hematoxylin/eosin, α-smooth muscle actin, and Picrosirius red to evaluate general aspects of the wound, inflammatory infiltrate, blood vessels, and Types I and III collagen fibers. Histological analysis showed that topical insulin cream increased the inflammatory cell infiltrate in the DI group (at 7 and 14 days postburn, p< .05) and blood vessels (at 14 days postburn, p < .05) to levels similar to those of groups CP and CI. Wounds treated with topical insulin cream (CI and DI groups) showed significantly stronger staining for fibrillar collagen than wounds of the DP group. The use of topical insulin may reduce the duration of the inflammatory phase; improve wound reepithelialization, tissue granulation, and wound contraction; and increase collagen deposition in second-degree burns in healthy and diabetic animals.

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Section: Discussionmentioning

confidence: 92%

Effect of Topical Insulin on Second-Degree Burns in Diabetic Rats

Azevedo

Pessoa

Moreira

et al. 2015

Biological Research For Nursing

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“…HCF is particularly suitable for heavily exuding wounds, which require optimal retention of moisture at the surface of the wounded area. 6,[12][13][14][15] Wound fluid contains several cytokines, chemokines, and growth factors, and it has been shown that the components of wound fluid varied depending on the type of dressings used. 9,11 In a past study, HCF-induced moist conditions were reported to be beneficial to the wound healing process by increasing hyaluronan synthesis and decreasing proinflammatory cytokines in the periwound skin.…”

Section: Discussionmentioning

confidence: 99%

“…6,[12][13][14][15] In a previous study, we showed that HCFs were beneficial to wound healing by increasing the gene expression of hyaluronan synthase 3 and peroxisome proliferator-activated receptor-a in the periwound skin. 16 Additionally, we showed that HCF reduced inflammatory cytokine levels in the periwound skin and the granulation tissue.…”

mentioning

confidence: 99%

Hydrocellular foam dressing increases the leptin level in wound fluid

Yoshino

Nakagami

Ohira

et al. 2015

Wound Repair Regeneration

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Hydrocellular foam dressing (HCF) absorbs excessive wound fluid, which contains various cytokines and growth factors, and ensures a moist environment to promote wound healing. However, the molecular mechanisms underlying the wound fluid component changes induced by HCF are poorly understood. In the present study, we examined the effect of HCF on wound healing and the associated regulatory mechanisms in relation to variations in cytokine levels in the wound fluid. We created full-thickness wounds on the dorsolateral skin of rats and collected the resulting wound fluid samples. HCF was immersed in a plate containing the wound fluids. HCF was then removed and the excess wound fluid remaining in the plate was examined by cytokine array and enzyme-linked immunosorbent assay. We also used a rat model and human dermal fibroblast cultures to examine the effect of wound fluid component changes during the wound healing process. Upon treatment with HCF, leptin levels were upregulated in the wound fluid. Fibroblast proliferation was enhanced and the effect was suppressed in the presence of leptin antagonist. In our in vivo model, HCF increased wound contraction compared with film dressings and this positive effect of HCF was suppressed by addition of leptin antagonist. Our results suggest that dermal fibroblast proliferation is upregulated by HCF due to increased leptin level at the wound surface, and these effects promote wound healing. We believe that the present study contributes to furthering the understanding of the mechanisms underlying the effects of HCF-induced wound healing.

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“…To clarify the mechanisms resposible for the wound-promoting effect of this type of dressing, the other stages of wound healing, such as granulation tissue formation phase, should be addressed. Kunugiza et al [21] reported that the hydrocellular foam dressings accelerated neovascularization in the granulation tissue by enhancing vascular endothelial growth factor. Taken together, this type of dressing has beneficial effects on both granulation tissue and re-epithelialization in the full-thickness wound.…”

Section: Discussionmentioning

confidence: 99%

Hydrocellular Foam Dressing Promotes Wound Healing along with Increases in Hyaluronan Synthase 3 and PPARα Gene Expression in Epidermis

et al. 2013

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BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of hydrocellular foam dressing on hyaluronan, which has been shown to have positive effects on wound healing, and examined its regulatory mechanisms in rat skin.Methodology/Principal FindingsWe created two full-thickness wounds on the dorsolateral skin of rats. Each wound was covered with either a hydrocellular foam dressing or a film dressing and hyaluronan levels in the periwound skin was measured. We also investigated the mechanism by which the hydrocellular foam dressing regulates hyaluronan production by measuring the gene expression of hyaluronan synthase 3 (Has3), peroxisome proliferator-activated receptor α (PPARα), and CD44. Hydrocellular foam dressing promoted wound healing and upregulated hyaluronan synthesis, along with an increase in the mRNA levels of Has3, which plays a primary role in hyaluronan synthesis in epidermis. In addition, hydrocellular foam dressing enhanced the mRNA levels of PPARα, which upregulates Has3 gene expression, and the major hyaluronan receptor CD44.Conclusions/SignificanceThese findings suggests that hydrocellular foam dressing may be beneficial for wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. We believe that the present study would contribute to the elucidation of the mechanisms underlying the effects of hydrocellular foam dressing-induced moist environment on wound healing and practice evidence-based wound care.

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A hydrocellular foam dressing versus gauze: effects on the healing of rat excisional wounds

Abstract: These results supports the hypothesis that gauze encourages scab formation, which impairs epithelialisation and increases VEGF expression. In contrast, hydrocellular foam dressing accelerates epithelialisation and new vessel formation in granulation tissue.

Cited by 12 publications

References 20 publications

Effect of Topical Insulin on Second-Degree Burns in Diabetic Rats

Effect of Topical Insulin on Second-Degree Burns in Diabetic Rats

Hydrocellular foam dressing increases the leptin level in wound fluid

Hydrocellular Foam Dressing Promotes Wound Healing along with Increases in Hyaluronan Synthase 3 and PPARα Gene Expression in Epidermis

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