A hydroxyapatite coating covalently linked onto a silicone implant material

Furuzono, Tsutomu; Sonoda, Kensaku; Tanaka, Junzo

doi:10.1002/1097-4636(200107)56:1<9::aid-jbm1073>3.0.co;2-2

Cited by 60 publications

(33 citation statements)

References 36 publications

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“…A composite of sintered HA microparticles covalently coupled to a silicone elastomer was developed 11. The HA layer was formed by covalently linking amino groups of modified HA particles and a silicone substrate grafted with a polymer containing carboxyl groups.…”

Section: Introductionmentioning

confidence: 99%

Physical and biological evaluations of sintered hydroxyapatite/silicone composite with covalent bonding for a percutaneous implant material

et al. 2003

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A composite (HA/silicone) of hydroxyapatite (HA) microparticles with an average diameter of 2.0 micro m covalently linked to a silicone substrate has been developed, and its physical and biological properties as a percutaneous soft-tissue-compatible material have been evaluated. In tensile property measurement, samples of HA/silicone and the original silicone were similar in tensile strength, ca. 7.8 MPa, and elongation at break, ca. 570%. It was found that chemical surface modification with HA particles presented no mechanical disadvantage. In an adhesive-tape peeling test, scanning electron microscopic (SEM) observation showed that HA particles coupled directly to the substrate were not removed. HA particles may bond strongly with the substrate. In human periodontal ligament fibroblast attachment and proliferation experiments, the number of cells attached to HA/silicone was 14 times greater than that attached to the original silicone after 24 h of incubation. The value on HA/silicone was ca. 80% versus that on a tissue-culture plastic used as a positive control. After 72 h of incubation, the number of cells grown on HA/silicone increased to the level of the positive control. In observation of fluorescence microscopy stained by Hoechst 33342, cells appeared to tightly adhere to HA particles coupled to the silicone sheet due to intact nuclear morphology. Observation of cells by fluorescence dye with rhodamin phalloidin showed an extensive F-actin cytoskeleton on HA/silicone. In a 4-week animal implant test, force required to pull out the HA/silicone sheet was 15 times that of the original silicone. HA-particle coating on silicone with covalent linkage gave the inert surface bioactivity. The HA composite thus effectively prevents germ infection percutaneously.

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Section: Introductionmentioning

confidence: 99%

Physical and biological evaluations of sintered hydroxyapatite/silicone composite with covalent bonding for a percutaneous implant material

et al. 2003

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“…The hydroxyl groups Fig. 7 Schematic of the Sr-HA particle surface treated by MMA have been proven to have the ability to react with organic functional groups [33,34].…”

Section: Surface Treatment By Bisphosphonatesmentioning

confidence: 99%

Development and clinical trial of a novel bioactive bone cement

Leong

2008

Front. Med. China

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Strontium (Sr) and related compounds have become more attractive in the prevention and treatment of osteoporosis. Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing hydroxyapatite (Sr-HA) filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) resin. This bone cement is superior to conventional polymethylmethacrylate (PMMA) bone cement in bioactivity, biocompatibility, and osseointegration. It also has shown sufficient mechanical strength properties for its use in percutaneous vertebroplasty (PVP) and total hip replacement (THR). In this paper, we review the in vitro, in vivo and clinical evidence for the effectiveness of this bioactive bone cement.

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“…For example, in bone substitutes and bone tissue engineering scaffolds, bonelike apatite, i.e., calcium-deficient and carbonate-containing apatite with low crystallinity and defective structure, would be suitable in terms of biological performance. 5) Among conventional apatite coating processes for polymers, such as spraying, 6) silane-coupling, 7) alternate dipping, 8) and biomimetic 9)-22) processes, the biomimetic process is particularly useful for obtaining apatite with adjustable composition and structure. In this process, apatite coating is generally carried out by immersing a surface-modified polymer in a neutralized calcium phosphate aqueous solution, which is supersaturated with respect to apatite similarly to body fluid (Fig.…”

Section: Introductionmentioning

confidence: 99%

Development of apatite-based composites by a biomimetic process for biomedical applications

Oyane

2010

J. Ceram. Soc. Japan

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A new biomimetic process for apatite coating on polymeric materials has been developed. In this process, the surface of a polymer is modified with amorphous calcium phosphate (ACP), and then the polymer is immersed in a supersaturated calcium phosphate solution. The new biomimetic process has the advantages of safety, simplicity, and applicability to various types and forms of polymeric materials. By adding a biomolecule (such as protein, antibacterial agent, or DNA) to the supersaturated solution, immobilization of a biomolecule into the apatite coating while retaining the intrinsic biological activity of the biomolecule is possible. As a result of this, the base polymer would possess biological activity to control cell behaviors (such as adhesion, proliferation, and differentiation), in addition to good biocompatibility owing to the apatite. Hence, the new biomimetic process and the resulting composites have a wide variety of biomedical applications including tissue engineering scaffolds, percutaneous devices, and gene delivery carriers.

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A hydroxyapatite coating covalently linked onto a silicone implant material

Cited by 60 publications

References 36 publications

Physical and biological evaluations of sintered hydroxyapatite/silicone composite with covalent bonding for a percutaneous implant material

Physical and biological evaluations of sintered hydroxyapatite/silicone composite with covalent bonding for a percutaneous implant material

Development and clinical trial of a novel bioactive bone cement

Development of apatite-based composites by a biomimetic process for biomedical applications

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