A low energy ion beamline for TwinEBIS

Pahl, Hannes; Bencini, Vittorio; Breitenfeldt, M.; Costa, A. R. G.; Pikin, A.; Pitters, Johanna; Wenander, F.

doi:10.1088/1748-0221/13/08/p08012

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…This LINAC concept consists of 5 substructures. A TwinEBIS source [14,15] delivers 12 C 6+ -ions. The ions are initially accelerated and transferred to a subsequent RFQ accelerator by the Low Energy Beam Transport (LEBT).…”

Section: Hadron Minibeam Irradiation Facility Conceptmentioning

confidence: 99%

A carbon minibeam irradiation facility concept

Mayerhofer

Bencini

Sammer

et al. 2023

J. Phys.: Conf. Ser.

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In minibeam therapy, the sparing of deep-seated normal tissue is limited by transverse beam spread caused by small-angle scattering. Contrary to proton minibeams, helium or carbon minibeams experience less deflection, which potentially reduces side effects. To verify this potential, an irradiation facility for preclinical and clinical studies is needed. This manuscript presents a concept for a carbon minibeam irradiation facility based on a LINAC design for conventional carbon therapy. A quadrupole triplet focuses the LINAC beam to submillimeter minibeams. A scanning and a dosimetry unit are provided to move the minibeam over the target and monitor the applied dose. The beamline was optimized by TRAVEL simulations. The interaction between beam and these components and the resulting beam parameters at the focal plane is evaluated by TOPAS simulations. A transverse beamwidth of < 100 μm (sigma) and a peak-to-valley (energy) dose ratio of > 1000 results for carbon energies of 100 MeV/u and 430 MeV/u (∼ 3 cm and 30 cm range in water) whereby the average beam current is ∼ 30 nA. Therefore, the presented irradiation facility exceeds the requirements for hadron minibeam therapy.

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Section: Hadron Minibeam Irradiation Facility Conceptmentioning

confidence: 99%

A carbon minibeam irradiation facility concept

Mayerhofer

Bencini

Sammer

et al. 2023

J. Phys.: Conf. Ser.

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“…It does not depend on the intensity and can be as low as 10 μs, which would translate into an instantaneous current of 4 mA. By applying a ramp of a few 100 V to the drift tubes, the pulse length can be shortened further, however, it is not recommended as 10 μs is sufficiently short and the high instantaneous current would cause significant space charge effects in the low energy transfer line ( 122 ). In addition, the longitudinal energy spread might lead to chromatic aberrations in the extraction and low energy transfer systems.…”

Section: Analysis By Accelerator Component/stagementioning

confidence: 99%

Technical Design Report for a Carbon-11 Treatment Facility

Penescu¹,

Stora

Stegemann

et al. 2022

Front. Med.

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Particle therapy relies on the advantageous dose deposition which permits to highly conform the dose to the target and better spare the surrounding healthy tissues and organs at risk with respect to conventional radiotherapy. In the case of treatments with heavier ions (like carbon ions already clinically used), another advantage is the enhanced radiobiological effectiveness due to high linear energy transfer radiation. These particle therapy advantages are unfortunately not thoroughly exploited due to particle range uncertainties. The possibility to monitor the compliance between the ongoing and prescribed dose distribution is a crucial step toward new optimizations in treatment planning and adaptive therapy. The Positron Emission Tomography (PET) is an established quantitative 3D imaging technique for particle treatment verification and, among the isotopes used for PET imaging, the 11C has gained more attention from the scientific and clinical communities for its application as new radioactive projectile for particle therapy. This is an interesting option clinically because of an enhanced imaging potential, without dosimetry drawbacks; technically, because the stable isotope 12C is successfully already in use in clinics. The MEDICIS-Promed network led an initiative to study the possible technical solutions for the implementation of 11C radioisotopes in an accelerator-based particle therapy center. We present here the result of this study, consisting in a Technical Design Report for a 11C Treatment Facility. The clinical usefulness is reviewed based on existing experimental data, complemented by Monte Carlo simulations using the FLUKA code. The technical analysis starts from reviewing the layout and results of the facilities which produced 11C beams in the past, for testing purposes. It then focuses on the elaboration of the feasible upgrades of an existing 12C particle therapy center, to accommodate the production of 11C beams for therapy. The analysis covers the options to produce the 11C atoms in sufficient amounts (as required for therapy), to ionize them as required by the existing accelerator layouts, to accelerate and transport them to the irradiation rooms. The results of the analysis and the identified challenges define the possible implementation scenario and timeline.

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“…as g/L must not exceed unity. Equations ( 5), (6), and ( 7) form a nonlinear system that is easily solved iteratively, converging within a few iterations. The determined output energy W out is then used as input energy W in for the subsequent cell, and the procedure is repeated until the required output energy is reached.…”

Section: Cell-by-cell Designmentioning

confidence: 99%

“…The rationale of such a machine is to improve the aspect ratio of its footprint, studying a solution that could better fit into a hospital facility without affecting the treatment beam properties. In the low energy section of the machine, fully stripped carbon ions ( 12 C 6+ ) are produced by the ion source (TwinEBIS, operating at CERN [5]), transported in the Low Energy Beam Transport (LEBT) [6] and matched to the Radio Frequency Quadrupole (RFQ), which represents the first rf accelerating structure. The RFQ has the critical role of shaping the beam in both the transverse and the longitudinal plane and prepare it for the injection in the following accelerating structures.…”

Section: Introductionmentioning

confidence: 99%

750 MHz radio frequency quadrupole with trapezoidal vanes for carbon ion therapy

Bencini,

Pommerenke,

Grudiev

et al. 2020

Preprint

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High-frequency linear accelerators are very suitable for carbon ion therapy, thanks to the reduced operational costs and the high beam quality with respect to synchrotrons, which are presently the only available technology for this application. In the framework of the development of a new linac for carbon ion therapy, this article describes the design of a compact 750 MHz Radio Frequency Quadrupole (RFQ) with trapezoidal vanes. A new semi-analytic approach to design the trapezoidalvane RFQ is introduced together with the relevant beam dynamics properties. The RFQ is split into two decoupled rf cavities, both of which make use of a novel dipole detuning technique by means of length adjustment. The splitting is described both from the rf and the beam dynamics point of view. The paper concludes with the rf design of the full structure, including maximum surface field and thermal studies.

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A low energy ion beamline for TwinEBIS

Cited by 4 publications

References 23 publications

A carbon minibeam irradiation facility concept

A carbon minibeam irradiation facility concept

Technical Design Report for a Carbon-11 Treatment Facility

750 MHz radio frequency quadrupole with trapezoidal vanes for carbon ion therapy

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