A low-power implantable neurostimulator for small rodents with functional validation

Wright, Jason; Wong, Jason; Chang, Yao-Chuan; Ahmed, Umair; Zanos, Stavros; Datta-Chaudhuri, Timir

doi:10.1109/biocas.2019.8919215

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…One approach to combat this is to combine different layers to benefit from the strengths of each. Popular polymers include Parylene-C (Loeb et al, 1977 ), epoxies (Wright et al, 2019 ), and liquid crystal polymers (LCPs) (Gwon et al, 2016 ). From a high-level system design approach, it is important to recognize that implants for small animals do not need to last for decades, so a semi-hermetic approach using polymers may meet experimental requirements (Boeser et al, 2016 ).…”

Section: Technical Challengesmentioning

confidence: 99%

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Datta-Chaudhuri

2021

Bioelectron Med

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Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing. A wireless neuromodulation platform small enough for implantation in mice will significantly increase the utility of mouse models in bioelectronic medicine. This perspective examines the necessary functionality of such a system and the technical challenges needed to be overcome for its development. Recent progress is examined and the outlook for the future of implantable devices for mice is discussed.

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Section: Technical Challengesmentioning

confidence: 99%

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Datta-Chaudhuri

2021

Bioelectron Med

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“…Neural circuits with roles in the broad spectrum of diseases are constantly being identified and targeted by bioelectronics for therapeutic benefit in pre-clinical settings (Tsaava et al 2020). One of the major active areas for development is the ability to perform chronic stimulation in rodent models (Wright et al 2019;Mughrabi et al 2021), allowing the leveraging of the myriad of disease models into BEM therapy discovery. Understanding the anatomical differences among rodents, pigs and humans will help to refine current neuromodulation approaches, establish a pathway for translation from rodents to larger models, and drive future successful clinical trials.…”

Section: Summary and Future Directionsmentioning

confidence: 99%

The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future

et al. 2021

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There is a broad and growing interest in Bioelectronic Medicine, a dynamic field that continues to generate new approaches in disease treatment. The fourth bioelectronic medicine summit “Technology targeting molecular mechanisms” took place on September 23 and 24, 2020. This virtual meeting was hosted by the Feinstein Institutes for Medical Research, Northwell Health. The summit called international attention to Bioelectronic Medicine as a platform for new developments in science, technology, and healthcare. The meeting was an arena for exchanging new ideas and seeding potential collaborations involving teams in academia and industry. The summit provided a forum for leaders in the field to discuss current progress, challenges, and future developments in Bioelectronic Medicine. The main topics discussed at the summit are outlined here.

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“…Silicone encapsulation is appealing because it is compliant and can be used to minimize the foreign body response to the implant, however it suffers from similar issues as Parylene including moisture absorption and poor adhesion to underlying materials such as insulated wires leading to electrodes. Another approach to polymer-based packaging has been to incorporate layers of different polymers such as Parylene and epoxy (Wright et al 2019) to try to benefit from the different properties of the different materials, but the addition of additional encapsulation layers and the resulting added thickness can result in higher acoustical impedance and lower power transfer efficiency for ultrasound powered devices.…”

Section: Encapsulation Strategiesmentioning

confidence: 99%

Ultrasound powered piezoelectric neurostimulation devices: a commentary

2020

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Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piezoelectric neural stimulators work by converting ultrasound energy to electrical charge for neural stimulation. In addition to the benefits of wireless powering and miniaturization leading to less traumatic surgery, piezoelectric neural stimulators can also exhibit prolonged operational lifetimes for a long-term stable neural interface, and show promise for clinical translation. As one of first steps to demonstrate the value of ultrasound-powered piezoelectric neural interface, Li et al. developed a piezoelectric stimulator to activate spinal cord neural circuits for locomotion restoration in a rat model with spinal cord injury (SCI) and compared its efficacy with conventional electrical stimulation (ES). From the point of view of materials science, neural engineering and microelectronics, we provide our commentary on the article, highlighting its importance and discussing the issues that remain to be addressed in future studies in the emerging field of ultrasound powered piezoelectric neurostimulation devices.

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A low-power implantable neurostimulator for small rodents with functional validation

Cited by 5 publications

References 12 publications

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

The Fourth Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current progress, challenges, and charting the future

Ultrasound powered piezoelectric neurostimulation devices: a commentary

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