A meta-analysis: Parkinson's disease and dual-task walking

Raffegeau, Tiphanie E.; Krehbiel, Lisa M.; Kang, Nyeonju; Thijs, Frency J.; Altmann, Lori J. P.; Cauraugh, James H.; Hass, Chris J.

doi:10.1016/j.parkreldis.2018.12.012

Cited by 130 publications

(111 citation statements)

References 67 publications

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“…Our PD patients exhibited a slower walking speed and shorter stride length than controls at all speed conditions, which is similar to previous findings [1][2][3][4]6,20]. In addition, PD patients demonstrated higher CVs for spatiotemporal parameters at slower and faster speeds, and higher GA at slower and preferred speeds than controls.…”

Section: Discussionsupporting

confidence: 90%

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Gait Characteristics under Imposed Challenge Speed Conditions in Patients with Parkinson’s Disease During Overground Walking

Lee

Youm

Noh

et al. 2020

Sensors

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Evaluating gait stability at slower or faster speeds and self-preferred speeds based on continuous steps may assist in determining the severity of motor symptoms in Parkinson’s disease (PD) patients. This study aimed to investigate the gait ability at imposed speed conditions in PD patients during overground walking. Overall, 74 PD patients and 52 age-matched healthy controls were recruited. Levodopa was administered to patients in the PD group, and all participants completed imposed slower, preferred, and faster speed walking tests along a straight 15-m walkway wearing shoe-type inertial measurement units. Reliability of the slower and faster conditions between the estimated and measured speeds indicated excellent agreement for PD patients and controls. PD patients demonstrated higher gait asymmetry (GA) and coefficient of variance (CV) for stride length and stance phase than the controls at slower speeds and higher CVs for phases for single support, double support, and stance. CV of the double support phase could distinguish between PD patients and controls at faster speeds. The GA and CVs of stride length and phase-related variables were associated with motor symptoms in PD patients. Speed conditions should be considered during gait analysis. Gait variability could evaluate the severity of motor symptoms in PD patients.

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Section: Discussionsupporting

confidence: 90%

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by poor coordination and sustained gait impairments, such as decreased step length, stride length, and walking speed, which may increase the risk of falling [1][2][3][4]. Increasing the walking speed may increase the risk of falling in PD patients [2,3,5].…”

Section: Introductionmentioning

confidence: 99%

Gait Characteristics under Imposed Challenge Speed Conditions in Patients with Parkinson’s Disease During Overground Walking

Lee

Youm

Noh

et al. 2020

Sensors

View full text Add to dashboard Cite

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“…As yet, there is only one prior longitudinal study of predictive factors of a change in FOF in people with PD [24], and it did not include dual tasking as an independent variable. A recent meta-analysis showed that dual tasking have detrimental effects on gait speed in people with PD [42]. Several studies have shown that dual task training improves dual task performance in people with PD Parkinson's Disease 5 [43][44][45]; those that seem to benefit the most are those with a slow gait speed (while dual tasking) but with a good cognitive functioning [46].…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Concerns about Falling in People with Parkinson’s Disease: A 3-Year Longitudinal Study

Lindh-Rengifo

Jonasson

Mattsson

et al. 2019

Parkinson's Disease

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Introduction. Fear of falling (FOF) is more common in people with Parkinson's disease (PD) than in healthy controls. It can lead to several negative consequences such as restrictions in everyday life. Moreover, FOF is a risk factor for future falls. Aim. is study aimed to identify predictive factors of FOF (conceptualized as concerns about falling) after three years, with and without adjusting for concerns about falling at baseline, in people with PD. Methods. is study included 151 participants (35% women) with PD. At baseline, their mean (SD) age and PD duration were 68 (±9.0) and 9 (±6.1) years, respectively. e Falls Efficacy Scale-International (FES-I) was used as the dependent variable in multivariable linear regression analyses. Results. e mean (SD) FES-I score increased from 28.1 (11.9) to 33.1 (14.0) three years later (p < 0.001). e strongest (according to the standardized regression coefficient, β) predictor of concerns about falling was walking difficulties (β � 0.378), followed by age (0.227), problems maintaining balance while dual tasking (0.172), and needing help in daily activities (0.171). When adjusting for baseline FES-I scores, the strongest predictive factor was problems maintaining balance while dual tasking (β � 0.161), which was followed by age (0.131) and female sex (0.105). Conclusions. is study pinpoints several predictive factors of concerns about falling that are modifiable and which could be addressed in rehabilitation: perceived walking difficulties, having problems maintaining balance while dual tasking, and dependence on others in daily activities. e importance of dual tasking is a novel finding, which future studies need to confirm or refute. One should be aware of the fact that an increased age predicts concerns about falling with and without adjusting for baseline FES-I scores, whereas female sex predicts concerns about falling only when adjusting for baseline FES-I scores.

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“…In addition, the participants were asked to not synchronize with tactile stimuli from the robot under the RwA condition. It is well-known that the dual task decreases the gait performance of PD patients (Kelly et al, 2012;Raffegeau et al, 2019). When PD patients perform another task such as carrying a tray, generating words, and reacting to auditory of visual stimuli while walking, their stride length and velocity reduced.…”

Section: Methodsmentioning

confidence: 99%

Synchronized Tactile Stimulation on Upper Limbs Using a Wearable Robot for Gait Assistance in Patients With Parkinson's Disease

et al. 2020

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This study aimed to investigate whether using a wearable robot applying interactive rhythmic stimulation on the upper limbs of patients with Parkinson's disease (PD) could affect their gait. The wearable robot presented tactile stimuli on the patients' upper limbs, which was mutually synchronized with the swing of their upper limbs. We conducted an evaluation experiment with PD patients (n = 30, Modified Hoehn-Yahr = 1-3, on-state) to investigate the assistance effect by the robot and the immediate after-effect of intervention. The participants were instructed to walk 30 m under four different conditions: (1) not wearing the robot before the intervention (Pre-condition), (2) wearing the robot without the rhythm assistance (RwoA condition), (3) wearing the robot with rhythm assistance (RwA condition), and (4) not wearing the robot immediately after the intervention (Post-condition). These conditions were conducted in this order over a single day. The third condition was performed three times and the others, once. The arm swing amplitude, stride length, and velocity were increased in the RwA condition compared to the RwoA condition. The coefficient of variance (CV) of the stride duration was decreased in the RwA condition compared to the RwoA condition. These results revealed that the assistance by the robot increased the gait performance of PD patients. In addition, the stride length and velocity were increased and the stride duration CV was decreased in the Post-condition compared to the Pre-condition. These results show that the effect of robot assistance on the patient's gait remained immediately after the intervention. These findings suggest that synchronized rhythmic stimulation on the upper limbs could influence the gait of PD patients and that the robot may assist with gait rehabilitation in these patients.

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A meta-analysis: Parkinson's disease and dual-task walking

Cited by 130 publications

References 67 publications

Gait Characteristics under Imposed Challenge Speed Conditions in Patients with Parkinson’s Disease During Overground Walking

Gait Characteristics under Imposed Challenge Speed Conditions in Patients with Parkinson’s Disease During Overground Walking

Predictive Factors of Concerns about Falling in People with Parkinson’s Disease: A 3-Year Longitudinal Study

Synchronized Tactile Stimulation on Upper Limbs Using a Wearable Robot for Gait Assistance in Patients With Parkinson's Disease

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