A Method for Psychosocial Stress-Induced Reinstatement of Cocaine Seeking in Rats

Manvich, Daniel F.; Stowe, Taylor A.; Godfrey, Jodi R.; Weinshenker, David

doi:10.1016/j.biopsych.2015.07.002

Cited by 37 publications

(25 citation statements)

References 42 publications

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“…For instance, exposure to a social threat (Lo Iacono et al, 2016) or to social defeat (Bruchas et al, 2011; Titomanlio et al, 2013) reinstates a cocaine-induced conditioned place preference in mice and rats. Similarly, exposure to an olfactory cue that predicts social defeat reinstates cocaine-seeking responses in an operant task (Manvich et al, 2016). Social defeat also increases the vulnerability to cocaine-primed reinstatement in operant procedures; however, a brief, positive social interaction decreases vulnerability to cocaine-primed reinstatement under identical conditions (Ribeiro Do Couto et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Reinstatement of responding can also be induced and modified by social stimuli. For example, social stress caused by social defeat reinstates cocaine-seeking behavior (Manvich et al, 2016) and increases the effects of a cocaine prime (Ribeiro Do Couto et al, 2009). Conversely, the opportunity to interact with a social partner under drug-free conditions can prevent the reacquisition of a cocaine-induced conditioned place preference (Fritz et al, 2011).…”

Section: The Effects Of Social Cues On Cocaine-seeking Behaviormentioning

confidence: 99%

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The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

Smith

Zhang

Robinson

2016

Front. Behav. Neurosci.

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Social partners influence the likelihood of using drugs, developing a substance use disorder and relapse to drug use after a period of abstinence. Preclinical studies report that social cues influence the acquisition of cocaine use, the escalation of cocaine use over time, and the compulsive patterns of cocaine use that emerge during an extended binge. The purpose of this study was to examine the effects of social cues on the reinstatement of cocaine-seeking behavior after a period of abstinence. Male rats were obtained at weaning, assigned to triads (three rats/cage), reared to adulthood and implanted with intravenous catheters. Rats from each triad were then assigned to one of three conditions: (1) test rats were trained to self-administer cocaine and were tested for reinstatement; (2) cocaine partners were trained to self-administer cocaine and were predictive of response-contingent cocaine delivery; and (3) abstinent partners were not given access to cocaine and were predictive of extinction. The test rats alternated social partners every 5 days for 20 days such that responding was reinforced with cocaine in the presence of the cocaine partner (S+) for 10 days and not reinforced with cocaine in the presence of the abstinent partner (S−) for 10 days. Responding of the test rats was then extinguished over 7 days under isolated conditions. Tests of reinstatement were then conducted in the presence of the cocaine partner and abstinent partner under extinction conditions. Neither social partner reinstated responding relative to that observed on the final day of extinction; however, responding was greater in the presence of the cocaine partner (S+) than the abstinent partner (S−) during the reinstatement test. These data fail to demonstrate that a social partner reinstates cocaine-seeking behavior after a period of abstinence, but they do indicate that social partners can serve as either excitatory or inhibitory discriminative stimuli to influence drug-seeking responses.

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Section: Discussionmentioning

confidence: 99%

Section: The Effects Of Social Cues On Cocaine-seeking Behaviormentioning

confidence: 99%

The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

Smith

Zhang

Robinson

2016

Front. Behav. Neurosci.

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“…Regarding this, reinstatement of alcohol and cocaine seeking has been demonstrated after exposure to environmental cues paired with the SD experience (Funk, Harding, Juzytsch, & Le, ; Manvich, Stowe, Godfrey, & Weinshenker, ). Even after a period of 15 days of abstinence from cocaine, socially defeated animals show an increase of drug seeking during reinstatement testing (Covington & Miczek, ; Holly et al., ).…”

Section: Effects Of Social Defeat On Psychostimulant and Alcohol Rewardmentioning

confidence: 99%

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Montagud‐Romero

Blanco-Gandía

Reguilón

et al. 2018

Eur J of Neuroscience

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Social interaction is known to be the main source of stress in human beings, which explains the translational importance of this research in animals. Evidence reported over the last decade has revealed that, when exposed to social defeat experiences (brief episodes of social confrontations during adolescence and adulthood), the rodent brain undergoes remodeling and functional modifications, which in turn lead to an increase in the rewarding and reinstating effects of different drugs of abuse. The mechanisms by which social stress cause changes in the brain and behavior are unknown, and so the objective of this review is to contemplate how social defeat stress induces long-lasting consequences that modify the reward system. First of all, we will describe the most characteristic results of the short- and long-term consequences of social defeat stress on the rewarding effects of drugs of abuse such as psychostimulants and alcohol. Secondly, and throughout the review, we will carefully assess the neurobiological mechanisms underlying these effects, including changes in the dopaminergic system, corticotrophin releasing factor signaling, epigenetic modifications and the neuroinflammatory response. To conclude, we will consider the advantages and disadvantages and the translational value of the social defeat stress model, and will discuss challenges and future directions.

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“…; Manvich et al . ). Social stress increases alcohol consumption in rats when it occurs 2 but not 4 hours prior to self‐administration (van Erp & Miczek ; Caldwell & Riccio ), suggesting the timing of stress is important.…”

Section: Discussionmentioning

confidence: 97%

Social stress‐potentiated methamphetamine seeking

et al. 2018

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Human studies of substance use disorder show that psychological stress and drug availability interact following rehabilitation, contributing to the high relapse potential. Social stressors trigger particularly strong motivation for drug, but how this affects neuronal function to increase relapse is unknown. Animal models, which allow for the dissection of neural mechanisms, primarily utilize physical stressors to trigger relapse. To recapitulate psychosocial post-rehabilitation challenges in animals, we developed a model of social stress-potentiated methamphetamine (METH) seeking. Rats receive a single social defeat (SD) session after completion of self-administration and extinction of lever pressing. While a reminder of the SD was insufficient to reinstate METH seeking on its own, rats that received a reminder of SD followed by a METH-priming injection displayed potentiated reinstatement over METH-priming alone. Examination of neuronal activation patterns of the METH-primed reinstatement session identified c-Fos-immunoreactivity in the basolateral amygdala (BLA) as correlated with SD score, a measure of defeat latency. Rapidly defeated rats showed potentiated METH-primed reinstatement and elevated BLA c-Fos compared with controls. Conversely, rats that were undefeated during the social stress did not show potentiated METH-primed reinstatement or elevated BLA c-Fos. Interestingly, inactivation of the BLA with baclofen/muscimol prior to the stress reminder and METH-priming generated a potentiation of METH seeking in the undefeated rats, suggesting the BLA may mediate resilience to the stressor. This model provides a tool for the further dissection of neural mechanisms mediating social stress-potentiated relapse and for the development of relapse-reducing therapeutics.

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A Method for Psychosocial Stress-Induced Reinstatement of Cocaine Seeking in Rats

Cited by 37 publications

References 42 publications

The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

The Effects of Excitatory and Inhibitory Social Cues on Cocaine-Seeking Behavior

Social defeat stress: Mechanisms underlying the increase in rewarding effects of drugs of abuse

Social stress‐potentiated methamphetamine seeking

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