2020
DOI: 10.1073/pnas.2017918117
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A microbial metabolite synergizes with endogenous serotonin to triggerC. elegansreproductive behavior

Abstract: Natural products are a major source of small-molecule therapeutics, including those that target the nervous system. We have used a simple serotonin-dependent behavior of the roundwormCaenorhabditis elegans, egg laying, to perform a behavior-based screen for natural products that affect serotonin signaling. Our screen yielded agonists of G protein-coupled serotonin receptors, protein kinase C agonists, and a microbial metabolite not previously known to interact with serotonin signaling pathways: the disulfide-b… Show more

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Cited by 20 publications
(17 citation statements)
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“…Moreover, intestinal microbiota can modify serotonergic systems by means of their metabolites and affect behavior through the modulation of 5-HT signaling ( 236 ). In this context, some metabolites, including the short-chain fatty acids (SCFAs), are a key component in this modulation and directly affect the gut–brain axis ( 237 ).…”
Section: Intestinal Microbiota: Direct Effects On Serotonergic Systemmentioning
confidence: 99%
“…Moreover, intestinal microbiota can modify serotonergic systems by means of their metabolites and affect behavior through the modulation of 5-HT signaling ( 236 ). In this context, some metabolites, including the short-chain fatty acids (SCFAs), are a key component in this modulation and directly affect the gut–brain axis ( 237 ).…”
Section: Intestinal Microbiota: Direct Effects On Serotonergic Systemmentioning
confidence: 99%
“…The neurotransmitter serotonin (5‐hydroxytryptamine, 5‐HT) system may be the underlying mechanism of microbial regulation of host behaviour (Chen et al ., 2020 ). The 5‐HT system mainly consists of 5‐HT, 5‐HT receptor and the serotonin selective reuptake transporter (SERT).…”
Section: Introductionmentioning
confidence: 99%
“…It also controls egg-laying behaviour (Shivers et al 2009), as well as protective gene expression in offspring (Das et al 2020), so can affect future generations too. Notably, all these effects can be influenced by microbial metabolites that act as serotonergic agonists (Chen et al 2020), opening a way for manipulation of host physiology by pathogens. Interestingly, for these different roles, the regulatory factors upstream and downstream of NSY-1 can differ (e.g.…”
Section: What Has Been Retainedmentioning
confidence: 99%