A MIP-based low-cost electrochemical sensor for 2-furaldehyde detection in beverages

Pesavento, Maria; Merli, Daniele; Biesuz, Raffaela; Alberti, Giancarla; Marchetti, Simone; Milanese, Chiara

doi:10.1016/j.aca.2020.10.059

Cited by 41 publications

(16 citation statements)

References 45 publications

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“…MIP’s prepolymeric mixture was prepared according to the previously described procedure [ 39 , 40 , 41 ]; it consisted of 2-FAL, MAA, and DVB in the molar ratio of 1:4:40. DVB acted as crosslinker and solvent.…”

Section: Methodsmentioning

confidence: 99%

“…The MIP synthesized from this prepolymeric mixture was previously applied to different optical and electrochemical sensors [ 39 , 40 , 41 ] and characterized by Scanning Electron Microscopy (SEM), Fourier-transform infrared (FT-IR), and Differential Scanning Calorimetry (DSC) analyses [ 41 ] confirming the successful molecular imprinting. The MIP for 2-FAL was synthesized by a typical non-covalent approach, and the template recognition occurs through weak interactions and H-bonds.…”

Section: Methodsmentioning

confidence: 99%

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Detection of 2-Furaldehyde in Milk by MIP-Based POF Chips Combined with an SPR-POF Sensor

Alberti

Arcadio

Pesavento

et al. 2022

Sensors

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An innovative optical-chemical sensor has been used to detect the 2-furaldehyde (2-FAL) in milk. The proposed sensing approach exploits the refractive index changing in a microstructured chip based on a plastic optical fiber (POF) with orthogonal micro-holes containing a specific molecularly imprinted polymer (MIP). This POF-MIP chemical chip modifies the surface plasmon resonance (SPR) phenomena excited in another sensor chip realized in POFs (SPR-POF) and connected in series. The proposed sensor configuration exploits MIP receptors avoiding any modification of the gold film of the SPR platform. This work reports the performance, particularly the high sensitivity and low detection limit, in complex matrices such as buffalo milk fortified with 2-FAL and in different commercial kinds of cow milk thermally treated for pasteurization. The measurements were carried out in about ten minutes by dropping the solution under-test on the planar D-shaped POF surface of the chemical chip. In contrast, on the gold surface of the SPR-POF platform, a water drop is always placed to excite the SPR phenomenon, which is modulated by the chemical chip via MIP-2-FAL binding. Furthermore, the experimental results demonstrated the pros and cons of the proposed sensor system. Thanks to the high sensitivity of the sensor system, the detection of 2-FAL in the diluted milk sample (1:50) was achieved. The dilution is required to reduce the interferent effect of the complex matrix.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Detection of 2-Furaldehyde in Milk by MIP-Based POF Chips Combined with an SPR-POF Sensor

Alberti

Arcadio

Pesavento

et al. 2022

Sensors

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“…It has been shown that selectivity in SPE can be improved when MIPs are used as sorbents [8][9][10]. MIPs have been developed and intensively investigated in various fields such as separation, sensing, drug delivery, and enzyme-like catalysis as tailor-made synthetic receptors [11][12][13][14][15][16][17]. Magnetic MIPs as a new class of polymer materials used in pesticide residue analysis have also been extensively investigated in review reports to simplify and improve the sample preparation procedure [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic study and the extraction efficiency of bulk and precipitated ibuprofen‐imprinted polymer sorbents for gas chromatography and gas chromatography‐mass spectrometry ibuprofen bio‐analysis

Ebrahimi

Mozaffari

Mohammadiazar

2023

J of Separation Science

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Bulk and precipitation polymerization methods were used to prepare ibuprofenmolecularly imprinted polymers. Molecularly imprinted polymer-bulk and -precipitation were synthesized in acetonitrile, likewise molecularly imprinted polymer-bulk (mixture) and molecularly imprinted polymer-precipitation (mixture) in a mixture of acetonitrile/toluene (75:25 v/v). N 2 adsorption-desorption analysis data revealed that molecularly imprinted polymer-precipitation (mixture) has the highest specific surface area (200.74 m 2 /g). The surface chemistry and morphology of the synthesized sorbents were investigated by Fouriertransform infrared analysis and scanning electron microscope micrographs respectively. The prepared sorbents in the mixture of solvents were used in a dispersive solid-phase extraction process for selective extraction and preconcentration of ibuprofen from urine and human plasma samples. The detection limits were 62.91 and 7.89 ng/ml using molecularly imprinted polymer-bulk (mixture) and molecularly imprinted polymer-precipitation (mixture), respectively. Also, the sorbents showed selective behavior to extract ibuprofen in the presence of naproxen, fenoprofen, and ketoprofen. Overall, the results showed that the precipitation method in the mixture of acetonitrile/toluene resulted in the preparation of a sorbent with the highest extraction efficiency. Furthermore, a pharmacokinetic study was done. The maximum plasma concentration, the time required for maximum plasma concentration, and plasma half-life were 28.95 μg/ml, 2, and 2.39 h, respectively.

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“…HMF is a furan derivative, usually produced by sugar dehydration or Maillard reaction, especially in the process of food heat treatment and long‐term storage [1, 2]. It is widely used in the fields of pharmaceutical, chemical and food industry, for example as an industrial solvent, a selective extractant and being used to manufacture resins, detergents, pesticides and flavors, etc [3].…”

Section: Introductionmentioning

confidence: 99%

Black Phosphorene Modified Electrochemical Sensor for Fast Determination of 5‐Hydroxymethyl‐2‐furfural in Milk

Huang

Weng

et al. 2021

Electroanalysis

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The fast detection of 5‐hydroxymethyl‐2‐furfural (HMF) in food industry is vital because of its toxicity and mutagenicity. A glassy carbon electrode (GCE) modified with black phosphorene (BP) nanosheets was prepared and coated with Nafion to improve stability. The electrode has excellent electrochemical stability and current response for HMF electroreduction. The good linear relationship is in the concentration range of 0.1–10 μg/mL with the detection limit of 0.012 μg/mL. HMF electroreduction is a diffusion‐controlled process involving two electrons and two protons. The sensor was successfully applied to the measurement of HMF in milk with the recovery values of 92.92 %–96.33 %.

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A MIP-based low-cost electrochemical sensor for 2-furaldehyde detection in beverages

Cited by 41 publications

References 45 publications

Detection of 2-Furaldehyde in Milk by MIP-Based POF Chips Combined with an SPR-POF Sensor

Detection of 2-Furaldehyde in Milk by MIP-Based POF Chips Combined with an SPR-POF Sensor

Pharmacokinetic study and the extraction efficiency of bulk and precipitated ibuprofen‐imprinted polymer sorbents for gas chromatography and gas chromatography‐mass spectrometry ibuprofen bio‐analysis

Black Phosphorene Modified Electrochemical Sensor for Fast Determination of 5‐Hydroxymethyl‐2‐furfural in Milk

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