The main target of this study is to optimize the microstructure and to achieve an optimization for the mechanical properties in a biomedical Co-Cr-Mo (CCM) alloy with the nominal composition of Co-28Cr-6Mo (mass%) subjected to high-pressure torsion (HPT) and subsequent short annealing. The γ → ε phase transformation and grain re nement occur in the CCM alloy subjected to HPT processing at an equivalent strain (ε eq ) of 2.25 (CCM HPT ). The HPT processing causes a decrease in the elongation due to the formation of an excessive amount of ε phase. For removal of the excessive amount of ε phases, the CCM HPT was subjected to a short annealing (CCM HPTA ). The effect of the short annealing temperature (1073 K, 1273 K, and 1473 K; annealing time was xed at 0.3 ks) on CCM HPT was investigated. In addition, the effect of the length of duration for the short annealing (0.06 ks, 0.3 ks, and 0.6 ks;) for a xed annealing temperature of 1273 K on CCM HPT was studied. CCM HPTA(1273 K) annealed for 0.3 ks shows a good optimization of mechanical properties that include high strength and large elongation owing to its ultra ne-grained microstructure, and removal of excessive ε phases.