Threats to information security from inside an organisation are difficult to manage as insiders, by definition, have legitimate access to the organisation's information, consistent with their roles. Impacts of insider threats range from minor information compromise perhaps through carelessness, to catastrophic financial and reputational damage. Security managers are required to continually upgrade security measures to reduce the risk posed by insider threats, however with so many security controls to choose from, finding optimal security solutions based on benefit-cost is challenging. We have developed a risk-based framework called Security-in-Depth (SiD) where residual risk is the metric that assists the security manager to make informed decisions on which security packages contribute more to the organisation's security objectives. We present a case study to illustrate the way our framework is applied, customised to manage a range of insider threats. Uncertainties about the future threat spectrum and the future effectiveness of controls are included in the framework to inform the decisionmaking process.