A more than 10-year prospective, follow-up study of esophageal and pharyngeal acid exposure, symptoms and laryngeal findings in healthy, asymptomatic volunteers

Andersson, Olle; Möller, Riitta; Finizia, Caterina; Ruth, Magnus

doi:10.1080/00365520802321279

Cited by 11 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This symptom is commonly depicted as one of the more frequent symptoms of LPR disease [17]. It can, on the other hand, be argued that this is also a common symptom in a normal population [4] and thus is too unspecific for a disease-specific LPR questionnaire. Furthermore, the question "How often have you had postnasal drip?"…”

Section: Discussionmentioning

confidence: 99%

“…The disorder is characterized by hoarseness, cough, throat clearing, excessive mucus, globus sensation and dysphagia, symptoms that are both wide-ranging and of a chronic or intermittent nature [3,4]. LPR disease is diagnosed through a combination of symptoms, laryngeal findings and 24-h pH monitoring; however, these methods lack sufficient specificity [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Andersson¹,

Rydén²,

Ruth³

et al. 2009

Scandinavian Journal of Gastroenterology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Andersson¹,

Rydén²,

Ruth³

et al. 2009

Scandinavian Journal of Gastroenterology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a small 14-year follow-up study of healthy patients without symptoms with normal 24 h pH study at baseline, 39% developed laryngitis and almost half reported extraoesophageal symptoms—in particular, frequent throat clearing and cough 5. The number with pathological acid reflux on pH-metry increased over time (possibly owing to increasing body mass index), but there was no association between the presence of laryngitis or symptoms and acid exposure in the posterior pharynx.…”

Section: Introductionmentioning

confidence: 94%

Respiratory and laryngeal symptoms secondary to gastro-oesophageal reflux

Rafferty

Mainie

McGarvey

2011

Frontline Gastroenterol

View full text Add to dashboard Cite

REVIEW 212Gastro-oesophageal refl ux may cause a range of laryngeal and respiratory symptoms. Mechanisms responsible include the proximal migration of gastric refl uxate beyond the upper oesophageal sphincter causing direct irritation of the larynx and lower airway. Alternatively, refl uxate entering the distal oesophagus alone may stimulate oesophageal sensory nerves and indirectly activate airway refl exes such as cough and bronchospasm. Recognising refl ux as a cause for these extraoesophageal symptoms can be diffi cult as many patients do not have typical oesophageal symptoms (eg, heartburn) and clinical fi ndings on laryngoscopy are not very specifi c. Acid suppression remains an effective treatment in the majority of patients but there is growing appreciation of the need to consider and treat non-acid and volume refl ux. New opinions about the role of existing medical and surgical (laparoscopic techniques) treatment are emerging and a number of novel anti-refl ux treatments are under development.

show abstract

“…To have a complete overview of the voice-related problems, and to meet the needs of this group of patients, this type of symptoms should also be better understood. Three self-assessment scales address only the issue of throat related symptoms; however, all scales are designed to measure problems of more diagnose-specific character, the Glasgow and Edinburgh Throat Scale, designed for the evaluation of globus [13], the Reflux Symptom Index [14] and the Pharyngeal Reflux Symptom Questionnaire (PRSQ) [15], which specifically addresses reflux.…”

Section: Introductionmentioning

confidence: 99%

Throat related symptoms and voice: development of an instrument for self assessment of throat-problems

Åhlander

Rydell

Eriksson

et al. 2010

BMC Ear Nose Throat Disord

View full text Add to dashboard Cite

BackgroundSymptoms from throat (sensation of globus; frequent throat clearing; irritated throat) are common in patients referred to voice clinics and to ENT specialists. The relation to symptoms of voice discomfort is unclear and in some cases patients do not have voice problems at all. Instruments for patients' self-reporting of symptoms, and assessment of handicap, such as the Voice Handicap Index (VHI), are in common use in voice clinics. Symptoms from throat are however only marginally covered. Purpose: To develop and evaluate an instrument that could make the patients' estimation of symptoms from the throat possible. Further to facilitate the consideration of the relation between throat- and voice problems with the Throat subscale together with a Swedish translation of the Voice Handicap Index. Finally to try the VHI with the Throat subscale: the VHI-T, for test-retest reliability and validity.MethodsA subscale with 10 throat related items was developed for appliance with the VHI. The VHI was translated to Swedish and retranslated to English. The questionnaire was tried in two phases on a total of 23+144 patients and 12+58 voice healthy controls. The reliability was calculated with Cronbach's alpha, ICC and Pearson's correlation coefficient. The validity was estimated by independent T-test.ResultsThe difference in VHI-T scores between the patients and the voice-healthy controls was significant (p = < 0,01) and there was a good correlation of the test- retest occasions. The reliability testing of the entire questionnaire showed an alpha value of r = 0,90 and that for the Throat subscale separately a value of r = 0,87 which shows a high degree of reliability.ConclusionsFor the estimation of self-perceived throat and voice problems the scale on throat related problems together with the present Swedish translation of the Voice Handicap Index, (VHI) the VHI-Throat, proves to be a valid and reliable instrument. The throat subscale seems to help revealing a category of symptoms that are common in our patients. These are symptoms that have not earlier been possible to cover with the questionnaires designed for use in the voice clinic.

show abstract

A more than 10-year prospective, follow-up study of esophageal and pharyngeal acid exposure, symptoms and laryngeal findings in healthy, asymptomatic volunteers

Abstract: Esophageal acid exposure increases over time in previously symptom-free, healthy subjects. The increase in airway symptoms or laryngeal abnormalities is not directly related to increased acid exposure.

Cited by 11 publications

References 33 publications

Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire

Respiratory and laryngeal symptoms secondary to gastro-oesophageal reflux

Throat related symptoms and voice: development of an instrument for self assessment of throat-problems

Contact Info

Product

Resources

About